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Hep C Discussion Forum -> General Discussion -> Cirrohsis
Post Info TOPIC: Cirrohsis
JoAnneh


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RE: Cirrohsis
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This topic gives me hope!
So glad for members who have
knowledge and take time to
Share with others.
Thank you so much

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JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
mallani


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Phil is correct- I was trying to keep it simple. My Child-Pugh score is 5, which is why I say I am well-compensated at the moment. If I can obtain SVR, my hepatologist thinks I can stay at this level for 15-20 years, but obviously need regular monitoring for HCC. Progression of cirrhosis is very uncertain, and as HCV has only been around for 22 years, not a lot is known about cirrhosis after SVR.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
52baddog


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Thank you Phil and Mallani. I am learning so much from this forum. God Bless you all.



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Geno type 1b, F1 vl 640,000 enrolled in Gilead's sofosbuvir/ledipasvir -week 1 66, week 2 <25
Phil G


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Those parameters that Mallini described are collectively referred to as the Child-Pugh score. My insurance did not require a biopsy, but did require a Child-Pugh score indicating compensated and not decompensated liver disease.



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Geno 1A, VL 1.9 mm, SOT 12/2/11 - Pegintron/Ribavirin/Victrelis, UND since wk 8, EOT 6/15/12 (28 wks), SVR 11/30/12
52baddog


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Mallani:

what do you mean by well compensated?



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Geno type 1b, F1 vl 640,000 enrolled in Gilead's sofosbuvir/ledipasvir -week 1 66, week 2 <25
mallani


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Cirrhosis
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Well compensated means the liver is still doing it's job. Some blood tests that prove this are: bilirubin, APT, albumin, bleeding time (prothrombin time). If these are all normal, you are compensated. The liver enzymes ( ALT, AST and GGT) are not included. There are slightly elevated in my case, but they vary a lot and indicate hepatocyte damage. Interferon can cause a raised ALT by itself. Liver imaging by ultrasound, CT or MRI is essentially normal in my case.

You can live with compensated cirrhosis for a long time. If you can eradicate the HCV, there will not be any further cell death, fibrosis will stabilise, and it is possible for the liver to "mend" itself to some extent. The risk of HCC drops dramatically once the virus is removed.

Decompensated cirrhosis will cause end- stage liver disease. Patients may become jaundiced as bilirubin levels rise, there may be ascites due to low albumin, there may be bleeding from varices associated with portal hypertension and encephalopathy due to toxic compounds that the liver can no longer process.



-- Edited by mallani on Monday 18th of June 2012 07:14:49 AM

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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
greenqueen


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RE: Cirrohsis
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Moved to General Discussion

Love Steff xx



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Geno 3a. 24 wks tx 20/10/05 - 06/04/06. Achieved SVR.
mallani


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I have had cirrhosis for at least 10 years. Diagnosed by liver Bx and Fibroscan. I am still well compensated, and am now at week 14 of triple Rx with Victrelis. If the Rx is successful, my chance of developing HCC drop remarkably, and the degree of cirrhosis can be reduced. The Sx are pretty bad, particularly fatigue, and I think cirrhotics do not handle Rx as well. Will need 48 weeks of Rx.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
krowdog


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Sure, lots of people are doing it.

As far as I know, the only contraindication for tx is uncompensated liver disease (basically liver failure).

Brad



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(Geno 1a, Incivek Triple Tx, 6 month post TX - 9/20/2012 = SVR!!!)
52baddog


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If you have cirrohsis, can you still take the triple therapy without damaging your liver.



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Geno type 1b, F1 vl 640,000 enrolled in Gilead's sofosbuvir/ledipasvir -week 1 66, week 2 <25
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