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Hep C Discussion Forum -> On Treatment -> 48 wks seems to be general rule if you have cirrosis
Post Info TOPIC: 48 wks seems to be general rule if you have cirrosis
LanaiSurferGirl


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RE: 48 wks seems to be general rule if you have cirrosis
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I did 36...I guess it depends on the patient and what the doctor thinks is best.  Cirrhosis can be mild-severe and other factors can go in to that decision. :)



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geno 1a, mother & brother also hep c +...mom got a blood transfusion and passed it along.  Started tx with incivik 11/23/11 and brother started 2/8/2012.  Both of us und. at 4,8,12 and me at 24.  I am going 36 wks and brother is going 48 weeks.
Phil G


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I understand, Alan. I only did 28 weeks. It is what it is! I did not do 4 week post VL labs. Do my 12 week labs next week. Post tx so far has been mostly a recovery period, mostly good, some issues, NO anxiety over meds or labs. But that anxiety is returning as the labs approach. The wait for the results is going to just as wrenching as before, probably more. Unfortunately, that's a life-time sentence!



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Geno 1A, VL 1.9 mm, SOT 12/2/11 - Pegintron/Ribavirin/Victrelis, UND since wk 8, EOT 6/15/12 (28 wks), SVR 11/30/12
Neil_Canuck


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Here's some quotes from the profuct info sheet for Victrelis Triple Pack and the link for the full 96 page pdf

Duration of Therapy

The recommendations for duration of therapy differ for some subgroups from the dosing durations 

studied in the Phase 3 clinical trials (see CLINICAL TRIALS). Response-Guided Therapy is 

recommended for most individuals, but longer dosing is recommended in target groups 

(e.g., patients with cirrhosis).  

Patients with Poor Interferon Response

Consideration should be given to treating previously untreated patients who are poorly interferon responsive (less than a 1.0-log10 decline in HCV-RNA at TW 4 with PegIFN/RBV alone) with 

4 weeks of PEGETRON

 using the dosing recommendations listed in Table 6 followed by 44 weeks of VICTRELISin combination with PEGETRON

 (see CLINICAL TRIALS).  

Patients with Cirrhosis

Patients with compensated cirrhosis should receive 4 weeks of PEGETRON  using dosing recommendations listed in Table 6 followed by 44 weeks VICTRELISin combination with PEGETRON. 

 

http://www.merckfrosst.ca/assets/en/pdf/products/VICTRELIS_TRIPLE-PM_E.pdf



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58 yrs, cirrhotic, Genotype 1b 48 weeks Victrelis triple, SOT 7/13/12 victrelis started week 5. Starting VL 4,000,000  Wk 8 33 copies  Wk 24 UND, EOT UND 6 months post Tx DET. The battle goes on.
Bills


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Flag on the feild    Let's not jump to conclusions yet   we are all alittle different   maybe we can get a REF here and take it to the instant replay booth        I don't want to confuse the issue but this makes me think too

We have alot @ 48 weeks 

We have at least 1 @ 36 weeks

and Me rolling right into restarting treatment to to do another 24 weeks I have cirrosis stage 3

I will be doing 72 weeks total strait though

I did 48 weeks study DEB025 the drug was pulled by FDA @ about 7 months in I was UND so contiued Peg & Ribv 

But relaped at about week 45 they advised me to stay on Peg and Ribv till 48  and set up for Incivek

Week 49 got a  a whole new set of poisons I cried when i injected

so I do the 12 trp Tx and 12  Peg & Ribv Thats how I get to do 72 weeks

My VL was 9Mil + last year  relapsed / broke through   week 49 I was hitting VL @ 300,000 VL result at week 50 w/Incivek VL down to ( 26 )

Am I only getting 24 weeks of poision cause I was a good patient to do 48 weeks ( last year? )

But sereiously ?? Is it only 24  cause I never stopped taking interferon / Ribv and my VL was only 300 K ????

I think maybe  were all different   You make the call 

( note they did hint about maybe doing the full 48 again ) 2 years of poision ??? Can I handle that ???

Bills



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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.

news


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You guys are really starting to worry me. I just had my 4 weeks post labs, and will do them again at 12 and 24. I only did a 36 week treatment, 12 with Incivek, and 24 without. I really hope that ends up being enough.

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Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!
Biggyb


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Been good results with these new drugs, i will prob be on for 48wks  too. If it don't work at least your liver got a good rest. Even better stuff coming in a couple years. Hoopefully we won't need it...Good luck.



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58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
mallani


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Hi, If you are F3-4, you don't have cirrhosis. Only F4 equates to cirrhosis. Irrespective of this, the current Rx duration for F3-4 and F4 is 48 weeks. Yes, it is a long trip, but the SVR figures for shorter Rx duration are fairly depressing. The SVR figures for F3-4 after 48 weeks is >80% so the odds are good.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
ob1canoli


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I've seen the charts and general rule for best result to stay und........and like myself i have cirrossiss 3 to 4.....andi know theres a chance it still mite not clear for good...Its a battle.....incieviek is some mean stuff......if it clears up ill be very grateful......if not i won't go thru the misery again......best to everyone.



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