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Hep C Discussion Forum -> On Treatment -> How fast do you feel the interferon effect?
Post Info TOPIC: How fast do you feel the interferon effect?
mallani


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RE: How fast do you feel the interferon effect?
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I'm with you, Millie. After 27 weeks, have the shot, go to bed, wait 7 days, do it all again. Can't say I notice any effects.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
millie dswn


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I never stayed awake to find out, took sleepy meds, and before dozing off I rolled over and took a shot. Zzzzzzzzzz

48 weeks is a long haul, start pampering now!


Millie


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Diag 2000, infected  1978. Type 1a(tt) on 3rd round of peg/ riba Sep 7, 2012  started tele.riba.peg. Hopeful.......
Sed3


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At this point, about 32 weeks in, it takes about 2 minutes. But I've always been sensitive to the early effect of drugs, licit or, in a previous life, illicit.

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Type 1B - Unknown for 30 years, diagnosed September 2011, started treatment February 2012

8 weeks Incivik - stopped early due to rash.

Continuing Pegasys and Ribavirin until January 2013 - 48 weeks

Undetectable from week 4 --> present
iggle


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My first shot kicked in about 5 hours later, and that was absolute hell. For me, the first shot was extremely worse than every other one. Side effects for my second shot kicked in around the same time as the first, but it was much milder than the first time. After that, it became unpredictable. Some shots I have not felt anything until the next day. I think Margo describes the warm weird feeling pretty well, and that is usually the only short term side effect I feel anymore from the injection. The past few weeks, I have not felt any noticeable side effects at all. I don't know if that is good or bad, but it's made my weekends a lot easier.



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Rockyfeller


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I take my shot Friday evening, and it usually starts to kick in arond noon on Monday, fluey type symptoms for a couple of hours, then just the normal tiredness.  these last two weeks (shots 7 and 8) I had no effects at all.



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genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
LanaiSurferGirl


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It was unpredictable for me too.  The first one kicked in maybe 4 hours later.  Most of the time in treatment I would feel fine the day after and the effects would hit me 48-72 hours later and I would be down for the count with fever, chills, then night sweats for 2-3 days.  It is wierd that it would have this time delay but I am blaming it on the pegalated.

When I did treatment in 99-2000 I used the old version of interferon and did 3 injections per week.  I would feel the effects of that consistenly a few hours after injecting so have always done my shots right before bed with 2 advil :)



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geno 1a, mother & brother also hep c +...mom got a blood transfusion and passed it along.  Started tx with incivik 11/23/11 and brother started 2/8/2012.  Both of us und. at 4,8,12 and me at 24.  I am going 36 wks and brother is going 48 weeks.
Margo


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JoAnneh wrote:

Just like Margo!
Week 16 I felt immediately. I noticed a metal taste in my mouth and nose and got a little chilly. I felt great the next day. Now 2nd day I feel very tired.
As Scout mentioned its unpredictable.
Now that I have finished Invicek I feel
SO much better. Actually feel better than we I started medicine.
But with this med sx can change in a minute:)
JoAnne

Interesting to note, but I also feel better now then before starting treatment! No side effects, just nausea is bad...

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Geno 1b, relapsed in 2009 a week before my treatment was to be over. Started triple therapy on April 28th, 2012. UND at week 4,8,12,24,3 months post tx.
JoAnneh


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Just like Margo!
Week 16 I felt immediately. I noticed a metal taste in my mouth and nose and got a little chilly. I felt great the next day. Now 2nd day I feel very tired.
As Scout mentioned its unpredictable.
Now that I have finished Invicek I feel
SO much better. Actually feel better than we I started medicine.
But with this med sx can change in a minute:)
JoAnne

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JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
Tattoo Bear


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Cinnamon Girl wrote:

Thanks, Margo, good idea for a thread, very useful.  smile

Personally, it took even longer for me to feel any effects from my first shot.  I did it at 11am in my nurse`s office and it wasn`t until about 8pm that evening that I noticed feeling cold and shivery.  By about 11pm I was feeling really fluey and had quite a rough night.

None of my subsequent shots effected me nearly as badly, made me feel slightly fluey but mostly very tired for a couple of days.  Jill xx

 Same here Margo. I did not notice much until sbout 8 hours later. I was shivering and my teeth were chattering. I also felt very tired and feverish. I am interested what the second shot will do.....B



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Diagnosed: May 2012

Genotype: 1B,  VL: 9 million

Stage: 3/4 fibrosis, activity level: 3

Started TX: Aug. 31, 2012 .....Peginterferon alfa-2a, Copegus, Incivek 
Cinnamon Girl


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Thanks, Margo, good idea for a thread, very useful.  smile

Personally, it took even longer for me to feel any effects from my first shot.  I did it at 11am in my nurse`s office and it wasn`t until about 8pm that evening that I noticed feeling cold and shivery.  By about 11pm I was feeling really fluey and had quite a rough night.

None of my subsequent shots effected me nearly as badly, made me feel slightly fluey but mostly very tired for a couple of days.  Jill xx



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Scout


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Some days are ****tier than others. A few times I got through a week without feeling any ill effects, other weeks it was bad from shot to the next go around.



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Geno 1a, Viral load at 2 4, 8, 12 and 16  weeks, UND, Triple therapy Incevek done,   Peg & Riba Done, UND and making plans for the future!!
Mary Jane


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thanks for that bit of info storing away in my blond timers brain ...

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Do not go where the path may lead, go instead where there is no path and leave a trail.Ralph Waldo Emerson

1a - VL 22 million  F2- IL28B- CT / Inck-Riba- Peg triple therapy 9/15/12 UND 4/8/14  8 wks BT ..3/1/2013 done! 3wks Post UND
Margo


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After first shot it took 6 hours to take effect, now its minutes at week 18. I understand because it accumulates in the body. Warm feeling in the body that brings a weird feeling that makes me uncomfortable in my own body. Yesterday, literally 5 minutes after my shot, the "cleansing" began... Not too be too graphic. Skin became extremely sensitive and painful to touch.

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Geno 1b, relapsed in 2009 a week before my treatment was to be over. Started triple therapy on April 28th, 2012. UND at week 4,8,12,24,3 months post tx.
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