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Hep C Discussion Forum -> On Treatment -> Incivek why 12 weeks?
Post Info TOPIC: Incivek why 12 weeks?
Shep


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RE: Incivek why 12 weeks?
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Malcolm--you are a wealth of truly great info! Hope you are getting along. Thanks!

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Diagnosed 1996 genotype 1b VL alot tx starting 12/23/11 Victrelis UND week 8!!! 28 weeks of tx

Completed tx 7/6/12--still UND!!!!
mallani


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Hi Vern, I've been told that Incivek is so toxic that only 12 weeks can be given, compared with the much longer protocol with Victrelis. Perhaps our bodies adapt to the new 'normal', and the Sx become less pronounced. The short Rx duration is also meant to limit the development of drug-resistant viral mutations. The Inter. and Riba. are meant to 'mop-up' these mutations, which is why the AP's cannot be used alone. The 12 weeks was chosen as a result of the trials, as this period was tolerable, and gave the best SVR's.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Daook


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12Step Guy wrote:

 

I've heard that there is something about building up immunity to it? The reason I ask, is that as I get near the end of my 12 weeks- I seem to be having fewer sides? Or is 12 weeks just what they found to be optimal in the testing? Why not 10 weeks or 14?

 I think you might be right with the immunity. My body seems to be getting used to it after 6 weeks.



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Geno 1a, second time around, stable viral load since 1973, timing is right for new therapy
12Step Guy


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I've heard that there is something about building up immunity to it? The reason I ask, is that as I get near the end of my 12 weeks- I seem to be having fewer sides? Or is 12 weeks just what they found to be optimal in the testing? Why not 10 weeks or 14?



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Genotype 1a, IL 28 = CT  Interferon and riba 48 wks in 99, Daily Peg and Riba 18 months in 2007, Started Incivek, Peg, Riba 6/21/12. 4th stage cirrhosis. Last Dart will be May 23 2013.
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