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Hep C Discussion Forum -> General Discussion -> GS-7977 (Gilead) and (Bristol-Myers Squibb) Daclatasvir Update
Post Info TOPIC: GS-7977 (Gilead) and (Bristol-Myers Squibb) Daclatasvir Update
TazKat


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RE: GS-7977 (Gilead) and (Bristol-Myers Squibb) Daclatasvir Update
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Good.. so maybe there is still hope for me & others.. thanks i will try & keep up with this..



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
TazKat


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does this  have interferon & riba? or protease inhibitor?  i can't do the protease inhibitor any more. did the incivek but relapsed..



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
Neil_Canuck


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None of those drugs are used, riba or interferon. It is a different animal altogether called      polymerase inhibitor GS-7977,  It was used in combination therapy with  Bristol Myers HCV protease inhibitor asunaprevir producing a long-term cure for 77% of difficult-to-treat patients. Some of the clinical trials had a 100% cure rate. It was just 2 pills a day. Now Gillead is trying to combine GS 7977 and another drug in to a 1 capsule a day traeatment. They hope for that to be approved by 2014.



-- Edited by Neil_Canuck on Friday 21st of September 2012 08:28:22 PM

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58 yrs, cirrhotic, Genotype 1b 48 weeks Victrelis triple, SOT 7/13/12 victrelis started week 5. Starting VL 4,000,000  Wk 8 33 copies  Wk 24 UND, EOT UND 6 months post Tx DET. The battle goes on.
LC


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I signed.  If they don't get off their butts, then I think Achillion (or some other enterprising pharmaceutical) is going to eat the apple right off their head and it will be their lose not ours.biggrin  http://hepatitiscresearchandnewsupdates.blogspot.com/2012/04/easl-2012-achillion-announces-94-100.html



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Genotype 1a, VL 1,151,923.  51 years old.  Started treatment on AbbVie TOPAZ II clinical trial Oct 10, 2014!  Undetected at weeks 2 and 4! 
Bills


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(The HCV Coalition for "The Cure".) who originate the Petition against Gilead  sends me updates on Progress

 I think  

They did a good job of stating the reason for the petition up front It's about Gileads greed to have it all  while we wait and use Peg-inerferon and Ribaviri.

  Website is online NOW. http://hepc-cured.com     Is now online  for signing the petition    However, they are still working out some technical issues, i.e., when I try and post it on Facebook it shows up in Maintenance Mode  working on it

This blog below also   is also Very informative

http://hepatitiscnewdrugs.blogspot.com/2012/09/challenges-remain-in-reaching-100-cure.html

   It Has a lot of links to right  Looks to me like Gilead back pedaling to make there own version of the Daclatasvir ( for marketing )   It appears Gilead's in house equivalant to  Daclatasvir is a long way off  Late 2014  ( and could fail testing waisting very precious time )

 

We need to press them  The GS-7977 (Gilead) and (Bristol-Myers Squibb) Daclatasvir It is already past stage 2 testing   One more stage to FDA approval (( It's almost ready and 90-100% reliable )) Could it be worse that what we are doing right now? I would do it if I could

Please sign the petition

Thanks Bill S



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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.

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