Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Hep C Discussion Forum -> Post Treatment -> Liver after failed triple therapy
Post Info TOPIC: Liver after failed triple therapy
JoAnneh


Guru

Status: Offline
Posts: 1077
Date:
RE: Liver after failed triple therapy
Permalink  
 

Great info! JoAnne

__________________

JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
mallani


Guru

Status: Offline
Posts: 3398
Date:
Permalink  
 

Hi Nancy, My biopsies were in 1982 (F0), 1990 (F0-1) and 2000 (F3-4). Fibroscan in 2007 showed F4 (95% accuracy). I won't bother with another biopsy, as Fibroscan is so accurate with the new Echosens machine. I will get another Fibroscan after treatment, just to have on record. I hope it shows a drop to F3-4 at least.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
52baddog


Senior Member

Status: Offline
Posts: 133
Date:
Permalink  
 

Thanks Malcom, you know so much about HEP C and all these medical terms. I am in stage 1 and am going to wait for the new drug. I had a biopsy 2 months ago. Did you get biopsies every 3 years?



__________________

Geno type 1b, F1 vl 640,000 enrolled in Gilead's sofosbuvir/ledipasvir -week 1 66, week 2 <25
mallani


Guru

Status: Offline
Posts: 3398
Date:
Permalink  
 

Hi Nancy, The usual cycle is virus enters hepatocyte and uses cell compounds to replicate. The hepatocyte is damaged and may die, and releases cytokines that stimulate an inflammatory and fibrotic reaction. If you are undet. on Rx, there is no (or little) circulating virus, so this process comes to a stop. The liver has a remarkable ability to regenerate and heal itself, and many people can produce collagenases that resorb fibrosis. Thus the saying 'Your liver gets a rest' is very true, and liver damage may start to be repaired ( while undetected). If SVR is not attained, the virus returns and the cycle of hepatocyte damage, inflammation and fibrosis begins again. People vary enormously in their response, and some are lucky enough to have minimal inflammation and fibrosis.

So, in answer to your question, after failed Rx, you start where you left off, possibly with a slightly healthier liver. The VL may be lower but this does not equate to liver damage.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
52baddog


Senior Member

Status: Offline
Posts: 133
Date:
Permalink  
 

Does your liver get worse if you can't accomplish SVR after triple treatment?



__________________

Geno type 1b, F1 vl 640,000 enrolled in Gilead's sofosbuvir/ledipasvir -week 1 66, week 2 <25
Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.
Hep C Discussion Forum -> Post Treatment -> Liver after failed triple therapy
Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.