Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Hep C Discussion Forum -> On Treatment -> Allergy - why no prednisolon?
Post Info TOPIC: Allergy - why no prednisolon?
mallani


Guru

Status: Offline
Posts: 3398
Date:
RE: Allergy - why no prednisolon?
Permalink  
 

Hi Uval, prednisone and prednisolone are immunosupressants. It is thought that these cause elevation of VL, increased viral activity and accelerate liver fibrosis. Some researchers think short courses of these steroids are OK. In general, anything that decreases our immune response should be avoided in chronic HCV.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Uval951


Member

Status: Offline
Posts: 38
Date:
Permalink  
 

Silly question - why are prednisolon and similar hormones contraindicated  for allergy treatment?



__________________

 

Gen. 1b. 1st Tx in 2003 Rib/Peg. Biopsy F3-F4; 2nd Tx started 2/28/12, Pegasys+RibaPak+Victrelis for 48 weeks. VL: 260,000 (starting), 125,600 (4 weeks), UND-weeks 6-45.EOT 1/7/13 after 45 full weeks. Post Tx 4,12,24 weeks -UND  SVR!
Uval951


Member

Status: Offline
Posts: 38
Date:
Permalink  
 

Thanks Malcolm for the comprehensive answer. We are forced to use prednisolon to prevent therapy derailment on 35th week. Try to limit the 5 day course only. I hope this will not lead to virus return after 28 UND weeks. Thanks again.



-- Edited by Uval951 on Friday 26th of October 2012 02:09:51 AM



-- Edited by Uval951 on Friday 26th of October 2012 02:12:17 AM

__________________

 

Gen. 1b. 1st Tx in 2003 Rib/Peg. Biopsy F3-F4; 2nd Tx started 2/28/12, Pegasys+RibaPak+Victrelis for 48 weeks. VL: 260,000 (starting), 125,600 (4 weeks), UND-weeks 6-45.EOT 1/7/13 after 45 full weeks. Post Tx 4,12,24 weeks -UND  SVR!
Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.
Hep C Discussion Forum -> On Treatment -> Allergy - why no prednisolon?
Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.