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Hep C Discussion Forum -> Clinical Trial Participants -> QUAD Treatment
Post Info TOPIC: QUAD Treatment
Matt Chris


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RE: QUAD Treatment
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Hey Joe

Thanks for the update, it encourages all of us on treatment.

It seems necessary the longer we are on treatment.

I appreciate your comments "Stay positive, maintain a good attitude and healthy life style and above all keep on fighting" 

Yes will need to remind our self of this on a daily basis.

Matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
JoeV


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Thank you Jill, Jim, Greg, Matt and Biggyb!

I am grateful for all the support and words of encouragement. I received my week 24 lab results (end of treatment) and the viral load is still undetected! Now comes the true determination of whether or not the treatment worked...must be undetected in the next 3 lab tests over a 6 month period. 

Stay positive, maintain a good attitude and healthy life style and above all keep on fighting. I wish you all a very successful journey and happy endings. 

Joe



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Matt Chris


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Hey Joey

Congrats on makin it , UND after 6 weeks through 24 is a recipe for SVR

Welcome to the rest of your life, I will be joining you God willing.

Matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Greg


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Well done mate, onwards to SVR.

Cheers,

Greg



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The mind is like a parachute it works best when it is open. "The Dalai Lama" My blog: http://greghcv.wordpress.com/
Genotype 1a, started tx 1st Feb 2011, for 48 wks. Week 24 PCR 26/07/11 Non-Responder
New TX start date 12th Sept 2016 Harvoni x24 weeks.  VL 7.4 Mil. Week 4 "Undetected"
Biggyb


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Good job Joe !!!



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58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
Cinnamon Girl


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Fantastic, well done Joe!!  Congrats on finishing your 24 weeks!  smile  Best of luck for a speedy recovery, and with your tests over the next 6 months.  Yes, do stay in touch and let us know how things are going.  Cheers!



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
JIme


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Way to go Joe!!!! Congrats and now it's time to move on with the rest of your life Hep C free.  Enjoy!!!!!!



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jim

GT1a, St2 Lv2 last biopsy 2002, VL  11.4m,  start triple tx 9/30/11

VL 470 @4wks.....VL 22,000 @8wks  stopped tx

Round 2-  Started 3/16/12   PSI-7977, BMS-790052, Riba Undetectable day 14

Did 24 weeks Still UND 12 weeks post tx, SVR24!!!!!!! 2/14/13

 

 

 

 

 
JoeV


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Finished treatment this past Thursday 4/12!!! It was a great feeling not having to take any drugs or the shot on Friday There's still 6 more months to go on the Clinical Trial, which consists of 3 post treatment blood tests. All 3 test results during these 6 months must come back with UNDETECTED virus for me to be considered "CURED". I hope and pray that will be the case. Thank you very much to all of you that communicated with me and I wish you all the very best. I'll stay in touch, Joe

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Cinnamon Girl


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Hi Joe, good to hear of your continuing UND!!  Wow, 23rd shot tomorrow, how amazing is that, you`re almost there!  Thanks for keeping us updated, we really appreciate hearing about your progress on this QUAD trial.  It`s looking very promising for you, great!  smile



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
JoeV


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Hello everyone! End of week 20 results showed viral load still UND, hemoglobin holding at 10.9 and all other results are normal. I'm on week 22 of 24 weeks and this coming Friday I take my 23rd shot which will leave 1 to go!!! Take care, Joe



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Cinnamon Girl


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I`m doing fine, thanks Joe!  Yes, that level of Hb is bound to be making you feel tired, unfortunately, and having to put up with that constant pain sounds like a very unpleasant sx.  Are you in touch with other people in the same trial?

Sounds like you`re coping well with maintaining your normal daily activities though, and that must be a big help in keeping you moving forward.  Just be careful not to overdo things though!  wink

Best of luck, keep going!  ~ Jill



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
JoeV


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Hello Jill! I hope you are doing well. I'm holding up relatively well so far. I have fatigue due to low Hemoglobin, although it is holding up ok, and constant pain at the base of my neck that is typical SD of one of the drugs. I'm maintaining a social like and continue to exercise, but not as vigorously as prior to the treatment. I'm hoping and praying that I'll be undetected at weeks 20 and 24 and after treatment for 6 months so I can get that elusive SVR Take care, Joe



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Cinnamon Girl


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Hi Joe, congrats on still being undetected, that is good to hear!   Your Hb is holding up pretty well and is actually slightly higher than at your wk 12 results...how are you feeling now?  I`m glad it seems to be going by fast for you, not too much longer to go now!  smile

Thanks for the update, Jill



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
JoeV


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Hello everyone! I haven't been on here for sometime...since my week 12 results update. As of my last checkpoint, week 16 on Feb 13th, I'm still undetected! All other results were normal, except Hemoglobin that is at 10.9! Next checkpoint is week 20 on Mar 14th, then 4 weeks remaining. Time sure is flying by.  I hope all of you are doing well



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JoeV


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Well Malcolm, it looks like you are doing pretty well yourself! You are at week 45 with, I'm guessing, 3 weeks to go and your Hb is at 8.5. That's really good compared to what I have seen. I wish you the very best on a successful treatment. Joe

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Cinnamon Girl


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Great half way result, Joe!  Hope your cold clears up soon...keep up the good work! smile  ~ Jill



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
mallani


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Hi Joe,

Another Undet! Great stuff. You seem to be coping well.

I'm jealous- at Week 45 of the Victrelis triple my Hb is 8.5

Keep truckin'



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
JoeV


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Hello everyone, I received my end of week 12 (treatment midpoint) lab results today. Viral load still undetected. Hemoglobin 10.8, low white and red blood cell counts, all other labs normal. Unfortunately I have caught a bad cold which is not helping how I feel. Now I'm counting down the weeks To date fatigue and muscle pain in my upper back have been the worst side effects. I hope everyone going through treatment/clinical trials are having success and doing well physically and mentally. Joe

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JoeV


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Thank you, Jill, and Happy New Year to you

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Cinnamon Girl


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Great to see you`re making such good progress, Joe, keep up the good work!  Happy New Year!  smile  ~ Jill xx



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
JoeV


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Hi Malcolm, thank you and I hope you are doing well. From what I have read you are close to being done. I wish you success and good health in 2013. Happy New Year Joe

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mallani


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Hi Joe, you're looking good! Keep those undet.'s coming. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
JoeV


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Hi all, I received my week 8 results today. Still UND. Yippee!!! Now have mild anemia HmG 11.1. All other labs NORMAL. Rock on I hope all of you have a happy 2013 with lots of SVRs

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JoeV


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Hi Steff and thank you! The appointments went very well. The doctors think that I'm doing great , so far. I should have my week 8 lab results after Christmas. Merry Christmas!!!

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greenqueen


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Great news, Joe! smile Hope your appointment goes well today.

Steff xx



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Geno 3a. 24 wks tx 20/10/05 - 06/04/06. Achieved SVR.
JoeV


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Hello Jill. Thank you and A Merry Christmas to you

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JoeV


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Hello Malcolm. Thanks for the congrats. Yes, I have some side effects. So far, the worst is fatigue and I get out of breath doing physical activity. I can't do my runs anymore, but I can jog and do floor exercises with light weights 4 times per week. I had a rash on both arms that itched and burned a lot at times, but after the Mayo Clinic treated it for a week it is completely gone. I do have some muscle pain, especially in my upper back and base of the neck. Gums are becoming sensitive. So far so good for being almost done with week 8. Merry Christmas and I hope all is well with you

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Cinnamon Girl


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Very good news, Joe, congrats to you! Merry Christmas! smile  Jill xx



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
mallani


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Hi Joe, Congratz on the Undet! Sounds like you are coping well. Do you have any side effects? Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
JoeV


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I received my Week 6 (Dec 6, 2012) lab results today. Viral Load is UNDETECTED!!! Best Christmas present ever Now, just have to keep getting UND at every lab test. This Thursday (12/20) I will be having my end of week 8 lab and doctor appointment. YIPPEE!!!

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JoeV


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Hello Jime. Thank you for the encouraging words.

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JoeV


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Hi Bill! Malcolm is correct. My clinical trial is a phase 3 quad treatment for 24 weeks comprised of weekly shot of peg interferon alpha 2a, Asunaprevir (protease inhibitor), Daclatavir (ns5a protein inhibitor) and the always "fun" Ribavirin. So far the trial being done world wide is experiencing very promising results.

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JIme


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Looks great sp far Joe. Keep going. You'll be back to running before you know it.  Good luck.



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jim

GT1a, St2 Lv2 last biopsy 2002, VL  11.4m,  start triple tx 9/30/11

VL 470 @4wks.....VL 22,000 @8wks  stopped tx

Round 2-  Started 3/16/12   PSI-7977, BMS-790052, Riba Undetectable day 14

Did 24 weeks Still UND 12 weeks post tx, SVR24!!!!!!! 2/14/13

 

 

 

 

 
mallani


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Hi Bill, Joe's trial is for 24 weeks, using a NS-5A blocker, a NS-3 blocker and Peg and Riba. BMS did a Phase 2 trial without Peg and Riba, and only achieved an SVR rate of 36%. Another small Phase 2 trial using Asun. and Daclat. and Riba had 100% SVR rates for Geno 1b. For Geno 1a, Peg. was required. The impression I get is that the NS-5A / NS-5B blocker combination is doing best in the Interferon-free combinations ( although Riba may still be needed).



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Bills


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mallani wrote:

http://clinicaltrials.gov/show/NCT01573351

 

This is a link to Joe's trial. BMS are also doing a Peg. free trial.

 I'm glad BMS  is still in the game But  is the one above still using Peg and Riba ? I see it mentioned



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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.

JoeV


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I received week 4 results last week. VL less than 25 (same as week 2). Disappointed. Hemoglobin and red blood cells a little below normal. CK enzyme 1200 very high. Told to stop vigorous exercise, especially no weight lifting. I should have results for week 6 later this week. I've started my 7th week. It's going by fast I hope you all are doing well.

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JoeV


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Hello JoAnneh! So far I've had to abandon my 6 times per week 5 mile runs and settle for jogging and light weight exercising for 45 minutes per day 5 times per week. My skin itches and its difficult to go up the stairs in my house. Unfortunately, it's a 4 story house so lots of stairs But I'm happy with the results...so far. Joe

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JoeV


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Hello Mallani and thank you for the STICKY explanation. I'll continue to post updates under this same sticky. I'm cautiously optimistic with the results so far, but happy

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JoAnneh


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Joe, thanks for posting as we all
Are interested in new trails!
Keep us updated. Hope u r feeling good
JoAnne

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JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
mallani


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Hi Joe, a STICKY is a permanent post, usually on a particullar topic. Whenever you have news of your trial, post it in the 'QUAD treatment' sticky, so we get a continuous record of your progress. Obviously, if you want to post on another topic, do it in the 'On Treatment' or 'General Discussion' sections. You must be pretty happy with your results so far! Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
JoeV


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Hello Jill and thank you. I'll definitely keep everyone posted. I'm off to the Mayo Clinic for end of week 4 testing and should know results sometime next week. I'm hoping it keep moving in a positive direction and I'll be UND soon. Happy Thanksgiving. Joe

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JoeV


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Thank you I hope it keeps working and I'll be UND soon. Joe

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JoeV


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Hi Steff, Thank you for arranging the posts. I'm new at using this forum and I don't know some posts have disappeared and other truncated. Also, what does it mean to make the post STICKY? Take care, Joe

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Cinnamon Girl


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That is excellent news, Joe, really good going!! biggrin  Keep us posted...we`ll be following your progress with interest!

All the best to you, Jill xx



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
greenqueen


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That's an amazing result, Joe! smile

Steff xx

 



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Geno 3a. 24 wks tx 20/10/05 - 06/04/06. Achieved SVR.
greenqueen


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RE: Reposting Brystol Meyers Hallmark QUAD Treatment - WEEK 2 Update
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Hi Joe,

I've noticed your original thread is quite far down the list and wondering if your missing post's in there. I'm moving all your threads into one place, so you and everyone else can keep track of the results. I'll make it a "sticky" along with Jim and Rocky's journal smile

Steff xx



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Geno 3a. 24 wks tx 20/10/05 - 06/04/06. Achieved SVR.
JoeV


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I'm reposting because my original message got chopped off. Weird! Week 2 results VL less than 25. It was 53 at week 1 and 1.4 mil at start of treatment!!!!

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JoeV


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RE: QUAD Treatment
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Update on my 1st week on QUAD treatment: VL 1.4 mil at start and 53 at end 1st week. I'm now on 3rd week of treatment and waiting on 2nd week results from Mayo Clinic. Can't wait to see them and keeping fingers crossed Joe

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JoeV


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Mallani, thank you for the link. I'll have a look at it tonight.

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mallani


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http://clinicaltrials.gov/show/NCT01573351

 

This is a link to Joe's trial. BMS are also doing a Peg. free trial.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
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