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Hep C Discussion Forum -> General Discussion -> 2 and 3- the forgotten genotypes?
Post Info TOPIC: 2 and 3- the forgotten genotypes?
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RE: 2 and 3- the forgotten genotypes?
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You present a very frightening but accurate picture of what is going on with Hep C care worldwide. Here in the US, medical care is rapidly becoming socialized. So we will have Washington beaurocrats who generally can't pour piss from a boot, even with clear instructions printed on the sole, dictating policy where medical care is concerned. The delay and discussion about treatment protocols, focussing on cost rather than effectiveness, will be paid for with ruined lives. I expect we will find ourselves in precisely the same situation as our brothers and sisters in Europe and Australia within a couple of years. Third world status may be the norm before two more years.

But this is not a place for me to preach. I am just so glad that I began and finished my treatment before the lantern was pointed out into space. I'll probably regret this post in the morning, but right now this is how I feel. Please post your replies and rebuttals and we can discuss it. It just seems a shame that people in our predicament will be subject to the buffoonery of governments.

Alan



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Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!
mallani


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In the USA, Genotype 1 accounts for ~75% of all HCV cases.  Geno 2 is ~ 15% and Geno 3 about 7%.  Geno 1 is 'difficult to treat', so not surprisingly, most research has been aimed at treating this Genotype. However in some countries, Geno 2 and 3 are much more common.

Using Peg. and Riba, SVR rates for Geno 2 and 3 are very good (around 80%). This is provided there is not significant liver damage. There have been some trials using the new DAA's. Results using sofosbuvir and Riba are effective in these Geno's, but the results are not significantly better than for Peg and Riba. Phase 3 trials should hopefully give better results.

If you live in the USA, chances are that there will be new Rx options for the Geno 2-3's in the next 3 years. If you live outside the USA, and have failed SOC, you have a very long wait. The Australian Trials exclude patients with ANY previous Rx- the DrugCo's want Rx naive patients, and if you have cirrhosis, forget it.  My doc will be surprised if any of the new drugs (including sofosbuvir) are approved here (ie on the PBS) before 2020!

Here in Brisbane, liver transplant surgery was pioneered and perfected by Dr Russell Strong. It is infuriating that we are now a 3rd world country when it comes modern Rx.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
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