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Hep C Discussion Forum -> On Treatment -> Started.......
Post Info TOPIC: Started.......
mallani


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RE: Started.......
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Hi Dopey,

Congrats on giving Rx another try. We tend to use 'Victrelis' on the forum, rather than boceprevir.

As you are hopefully doing 48 weeks Rx, I think Victrelis is the better choice. If I could explain the lead-in, perhaps you'll understand about the significance of the VL drop. Both Victrelis and Incivek are useless on their own.  Resistant mutations rapidly develop (RAV's) and Peg. and Ribavirin are essential to control these RAVs. The Peg-interferon is particularly important- some patients are not sensitive to Peg. and their chances of SVR are reduced. These patients do not achieve a 1 or 2 log drop in VL after the leadin, and the same group of patients will not be Undetected at week 4 on the Incivek triple.

I have not read that Victrelis will not be with-held from patients who do not achieve a certain drop in VL during the leadin. The rules do change, but the stopping rules for Victrelis are VL >1000 at week 8 or week 12, and if not Undet. by week 24.

You would be regarded as a partial responder based on your previous Rx results. Even partial responders can achieve SVR, as the rules change with triple Rx compared to the old SOC.

Whether you are on Victrelis or Incivek, it is the same story. Peg and Riba must work for Rx to be successful.  Good luck!



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Dopey


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Thanks Jill and DJ. Yes DJ I just wish all this was explained to me before. When I saw my consultant in July 12 he said I would be going on boceprivir so when I was given a choice by the nurse I stuck with this cos I thought maybe the doc knows best!!! But had I known of the importance of the 4 week 1 log drop I may have jumped head first and gone for the telepravir.

Anyway I will fight my corner when we get to that bridge and push for the new drugs, the way I see it is what's the point of having new drugs if I'm not going to be able to try them.  The theory behind it is bizzare and 2 days later no matter how much i think about it i still can't see logic. 



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Treatment failed 2009 after 19 weeks. Treatment stopped after 4 weeks in Feb 2013 as viral load did not drop. The search continues....... again.......
DJ


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I agree with the statement "it takes guts to go another round of tx". Hopefully you will see a drop at 4 weeks. I didn't realize you had done this before and did not see a drop. Have you talked to the doctor about this and not just the nurse? I think that would have been an important piece of information to know when deciding on treatment. From what I have read (and I am not an expert by any means), the Incevek seems to be getting better results BUT at a higher price in terms of side effects. It is not an easy road. But it is also shorter in duration so that helps some (only 12 weeks on the Incevek). The victrelis is also getting good results but takes longer to achieve those results. But I suppose it is too late to change treatments at this point. It just seems like the doctor should have talked about all of this before you started.

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Genotype 3.  Treatment started on 1/11/2013 with Ribavirin and Pegatron.  Week 4 UND.  Week 12 UND.  Ended treatment on 6/28/2013.  Six months post treatment 12/04/2013 SVR.
Cinnamon Girl


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Hi again Dopey, good to hear you`ve started tx now.  It takes guts to go for another round of tx and I wish you all best of luck.  Just take it day by day and keep moving forward, and try not to worry about what happened last time.

Keep in touch!  smile  ~ Jill



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
2willy


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You have started the fight and that is the main thing.  To be honest, until I found this forum many of the health professionals I dealt with either projected they knew a lot or were at least honest and said I will have to check into it, yes the waiting is the hard part and if we worry too much we feed those dam squirles up in the head and they can make a mess out of your serenity.  I am on the 3 therapy with Victressi and though I do not like all the downs I have had I am coming up to week 24 and virol load will be checked and stopped if detected and continue for 48 wks if not my virol load started at 24 mil down to 17 mil down to 9,000 down to < 15 so there always is hope, keep in touch with this place as it is a good place to starve the squirls.

Bill and Family



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Geno type 1  rib and peg September 2012 , 5 weeks tripple and viral down to < 15 und april Aug 25 finished stay at peg 3 rib and eprex + blood transfussion finished treatment Aug 25 2013
Dopey


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BiggyB thanks for that I'm glad someone has said I made the right choice I was a bit scared whether I'd made the right decision. 

Thanks and well done DJ I hope I can say that in 4 weeks time!



__________________

Treatment failed 2009 after 19 weeks. Treatment stopped after 4 weeks in Feb 2013 as viral load did not drop. The search continues....... again.......
Dopey


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Thanks for the replies. Well Neil my worry is that when I asked the nurse about what my response was last time at week 4 she said that I'd not had any drop.  my viral load did drop by week 22 but not enough that's why treatment was stopped

Does that categorise me as a non responder???

.......I know I'm being silly and need to just focus a day at a time but.........



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Treatment failed 2009 after 19 weeks. Treatment stopped after 4 weeks in Feb 2013 as viral load did not drop. The search continues....... again.......
DJ


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I am Genotype 3 so am only doing the two meds and at 4 weeks I was UND. So I wouldn't worry. That should be enough time for yours to get down. At least by 1 log if not by more. Good Luck!

__________________

Genotype 3.  Treatment started on 1/11/2013 with Ribavirin and Pegatron.  Week 4 UND.  Week 12 UND.  Ended treatment on 6/28/2013.  Six months post treatment 12/04/2013 SVR.
Biggyb


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Good choice on the Victrelis. I went from about 1 million to 1600 in 3 weeks, been undetectable from wk 8 to now wk 31.



__________________

58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
Dopey


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Hi everyone guess ive been promoted to this part of the forum!  I went for my appointment today and have finally started. I injected myself and am now sat waiting for the side effects to kick in !!! 

I decided to go for boceprivir so am having a 4 week lead in. I will be on treatment for 48 weeks.

The nurse told more something that surprised me she said that if I didn't have a 1 log drop by week 4 all treatment will be stopped and they will not introduce the boceprivir. Now if I had been told this at my last appointment there's a possibility I might have gone for telepravir as opposed to boceprivir. 

I've come back from the appointment really concerned and I guess I'll be like this until my 4 week results are in. 



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Treatment failed 2009 after 19 weeks. Treatment stopped after 4 weeks in Feb 2013 as viral load did not drop. The search continues....... again.......
Neil_Canuck


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Not to worry, Log 1 should be no problem. At week 8 I was down to 33 copies from 4,000,000 which translates to a > Log 5 reduction I believe. If you were to begin with a VL of 3,000,000 you would need to be better than 300,000 at week 4. Shouldn`t be a problem unless you`re a non-responder.



-- Edited by Neil_Canuck on Monday 18th of February 2013 09:43:09 PM

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58 yrs, cirrhotic, Genotype 1b 48 weeks Victrelis triple, SOT 7/13/12 victrelis started week 5. Starting VL 4,000,000  Wk 8 33 copies  Wk 24 UND, EOT UND 6 months post Tx DET. The battle goes on.
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