Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Hep C Discussion Forum -> Clinical Trial Participants -> Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
Post Info TOPIC: Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
mallani


Guru

Status: Offline
Posts: 3398
Date:
RE: Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
Permalink  
 

Hi Rockyfeller,

Good to hear from you.  You're right about the names- the convention was that all protease inhibitors should end in ...previr, then Gilead comes out with Ledipasvir.  Good luck with your Rx- that's an excellent combo, and retirement will make it even easier.  Keep us posted.  Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Rockyfeller


Member

Status: Offline
Posts: 43
Date:
Permalink  
 

Way to go Bob, that is good news.
I did a clinical trial last year, GS 7977, pegasys and ribavirin for 12 weeks, was undetectable for a month, then it came back. Next week I am starting a new trial, sofosbuvir, ledi (whatever) previr (why can't they use names I can pronounce), and riba, for 12 weeks.. I hope to have the same results as you, guess I'll find out in 6 months.

The good part is, I retire on December 16th, so I can take it as easy as I need to whilst trying for the cure. I'm planning on messing around in my sailboat most of that time.

__________________

genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
Tig


Admin

Status: Offline
Posts: 9281
Date:
Permalink  
 

Congratulations Bob! Sounds like you had a long journey, with your share of bumps and bruises. But you got ahead of it and showed it who was in charge this time. It's great to hear it from one of the true HCV warriors! Stay in touch and let us know how your Hep free life treats you. Enjoy it and best of luck!



__________________

Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 
mallani


Guru

Status: Offline
Posts: 3398
Date:
Permalink  
 

Hi Bob,

Great news!  Persistence pays off.  Have a happy HepC-free life.  Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Biggyb


Guru

Status: Offline
Posts: 820
Date:
Permalink  
 

Great news Bob, very happy for you.



__________________

58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
Cinnamon Girl


Guru

Status: Offline
Posts: 5629
Date:
Permalink  
 

Matt Chris wrote:

Sometimes we can forget how many people visit the HepcFriends web site on a daily basis I don't know the exact numbers but I know they are in the upper 300 people a day and possible a lot more.  (Jill would probably know the exact amount)  The point is, our posts and words can have profound effects on peoples lives now and in the future so please keep it up and keep it real.

matt

 

 Yes, that`s right, Matt.  The number of people who visit the forum each day (members plus unregistered `guests`) is displayed at the bottom of the page, as you know, and it averages at about 350 - 400 in a 24 hour period (I don`t have the exact figures).  I do have statistics showing the number of individual `views` per day though, which is actually much higher, averaging at 3,704 per day! 



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
bowens44


Member

Status: Offline
Posts: 7
Date:
Permalink  
 

Zlikster wrote:

Hey Bob! SVR IT IS! :)

did u had any sx that you can attribute to DAAs? (since u have experience on Riba sx)

cheers!

None really. I had a little bit of tiredness but I attribute that to the riba,  



__________________
Zlikster


Guru

Status: Offline
Posts: 791
Date:
Permalink  
 

Hey Bob! SVR IT IS! :)

did u had any sx that you can attribute to DAAs? (since u have experience on Riba sx)

cheers!



__________________

GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Matt Chris


Guru

Status: Offline
Posts: 1782
Date:
Permalink  
 

Hey Bob

Big Congrats, that is sweet music to my ears and many others that have relapsed and that have been waiting to find a treatment with low effects and high cure rates.

Thanks Bob for getting back to us and giving hope for many hundreds of others.

Hepcfriends  this really illustrates how very important it is that we post are results during are treatment and most importantly after treatment because it can have profound effect on the attitude of HepC patients that are currently dealing with all the physical and Psyche issues that come with the disease.

Sometimes we can forget how many people visit the HepcFriends web site on a daily basis I don't know the exact numbers but I know they are in the upper 300 people a day and possible a lot more.  (Jill would probably know the exact amount)  The point is, our posts and words can have profound effects on peoples lives now and in the future so please keep it up and keep it real.

matt

 



__________________

"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
newmex


Senior Member

Status: Offline
Posts: 157
Date:
Permalink  
 

Congratulations!! And Thanks for sharing ,great to hear another positive outcome for those of us getting started or thinking about starting a treatment.Happy Thanksgiving to you and All!



__________________
John
Cinnamon Girl


Guru

Status: Offline
Posts: 5629
Date:
Permalink  
 

Hi Bob, good to hear from you again, that`s great news, congratulations!!  It was certainly 3rd time lucky for you, how fantastic!

You did very well getting onto this trial and what a contrast it must have been from your previous attempts, with few side effects and only 12 weeks of treatment!  You can relax and get on with the rest of your life now, knowing that you`ve finally beaten the virus that`s been lurking for so long!  Thanks for sharing your journey with us, very pleased for you!  smile



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
bowens44


Member

Status: Offline
Posts: 7
Date:
Permalink  
 

I haven't checked in in a long time....just got my 6 month post treatment results SVR!!   6 months after treatment the virus is not detected!



__________________
Karen


Senior Member

Status: Offline
Posts: 396
Date:
Permalink  
 

Hey Bob...what wonderful news...It is interesting to think about those little virus hiding out somewhere...Lets hope not!



__________________

Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
bowens44


Member

Status: Offline
Posts: 7
Date:
RE: Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribavirin
Permalink  
 

 

Just a quick update. Week 6 results, all is well.  still undetectable (been undetectable since week 2) , ast and alt still at 12.  HGB is a little low but nothing to worry about or to make me lower my Ribavirin dose.

 

 I have had some insomnia, they gave me a prescription for   temazepam for insomnia, I can sleep now but feel a little foggy in the morning.

No side affects really (other then the insomnia) even with ribaviran.

I am happy (happy doesn't begin to cover it) that I have been undetectable since sometime in week 2 but I'm starting to get nervous. The time to stop the drugs is fast approaching. Three more weeks. I am confident that I will remain undetectable while on the drugs...my worry is what happens when I stop taking them. 

Did I they kill all those little monsters hiding in my blood stream and my organs or are some of them still there skulking in the shadows  , waiting for the day when my protectors , my dragon slayers leave  so that they can reemerge and wage war on my liver once again.

Only time will tell...

 

 

 



__________________
Biggyb


Guru

Status: Offline
Posts: 820
Date:
RE: Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
Permalink  
 

Thats awesome news Bob. Keep up the good fight against a evil invader.



__________________

58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
bowens44


Member

Status: Offline
Posts: 7
Date:
Permalink  
 

Thanks Matt !

Karen I'm on 12 weeks with riba. It's been a piece of cake so far. Nothing like the misery of the last two attempts.

 



__________________
Karen


Senior Member

Status: Offline
Posts: 396
Date:
Permalink  
 

Matt..you are always an inspiration...keep it coming.



__________________

Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
Matt Chris


Guru

Status: Offline
Posts: 1782
Date:
Permalink  
 

Hey Bob, Michael, Scott and Karen

Or should I say The Gilead Band, sounds like you are all singing the same song, and how sweet it is ( Like Jackie Gleason use to say)

It's quite amazing that a group of people that don't really know each other have such a bond together, each of knowing the pain and sorrow of being us.

It's like being a Borg and part of the collective consciousness. (Startrek Character)

Anyway, we of the collective including my tribe the Abbott Labs group are riding a slightly different wave but see the destination very clearly and some have already made it to shore along with some of your group. 

If you have ever been far enough out from the shore swiming in the ocean, there is nothing more motivating than getting closer and closer to reaching the shore and the safety it brings. The great thing about being a collective we have each other to gain encouragment from, to make all the way.

So keep on posting and keep on talking and and keep truckin and we will all make it there.

Matt

image.jpg



Attachments
__________________

"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Karen


Senior Member

Status: Offline
Posts: 396
Date:
Permalink  
 

Your right...that was the wording.  I actually put n/a...on those questions!  Sure they did not appreciate that..

Yes...24 weeks but no Riba was a blessing.  How about you...see you are w/Riba 12 or 24?



__________________

Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
bowens44


Member

Status: Offline
Posts: 7
Date:
Permalink  
 

Hi karen,

I'm in North Carolina. The questions are probaly similar if not the same, they are all about health, mental state etc. It's just the wording that I find a little starnge. 'Has your hep C caused you to miss work?'  I have never really thought of it as 'my hep C'.....

I've never looked at it as something that is mine. To me it's always been something foreign. An invader, a parasite, an evil presence....something to be eradicated, expelled, defeated.....this is my third attempt in about 6 years, I hope it's the final battle. 

 

You're on for 24 weeks?

Good luck! I wish you the best.



__________________
Karen


Senior Member

Status: Offline
Posts: 396
Date:
Permalink  
 

Hi Bob,

Congrats..on your results!

Started this trial last Tuesday w/o ribaviran.

I had questions to answer but they were more about my mental and physical state.  Where are you doing this trial?   Seems like the questions would be standard/routine.

I will be posting on "A journey through the twists and turns of Sofosbuvir/GS-5885 Fixed-Dose Combination ± Ribavirin".  Keep us posted...good to have someone else on the forum going through the same treatment.



__________________

Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
bowens44


Member

Status: Offline
Posts: 7
Date:
Permalink  
 

Checking back in. Just finished week 6.

Week  4 results:

Viral Load: undetectable

ALT 12

AST 12

HGB 14.4

Good luck to those getting into this trial. Hopefully we can beat this thing..... 

On a side note, some of the wording of the questions that are asked really bother me.

Especially when the question begins 'Has you Hepititus C.....' They make it sound like its something I went down to the local Walmart and purchased. 'Yes give this pair of jeans and apple ...and oh yes, do you have any Hep c?'

This isn't MY hep c, this is an invader who is waging a war on MY liver...... 

 

 

 

 

 



__________________
Karen


Senior Member

Status: Offline
Posts: 396
Date:
Permalink  
 

Went Thursday for my screening on this study...Have my fingers crossed that I pass go!  If all is good, I start in 26 days. 



__________________

Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
gsx1250fa


Veteran Member

Status: Offline
Posts: 83
Date:
Permalink  
 

Good luck! I finished up this 12 wk arm 3.5 weeks ago. I went und at week 4. My 2 week post Tx draw was und. Had my 4 week draw (5 days early) yesterday. I am a 3 time Tx attempt/failure with early stage cirrhosis. Hopes and prayers :)



__________________
scotu


Member

Status: Offline
Posts: 44
Date:
Permalink  
 

That's great news!  Good luck and keep up the good work.

I have a history that sounds similar to your's...  Geno 1A, Probably got HEP C from 1972 Blood received for motorcycle accident (badly broken leg), 1st noted a Liver problem in the early 80's, but they couldn't spell HEP C in those days.  Finally diagnosed in 1999.  Been on many treatments, including Undetecatble at all keep checks on the Telaprevir Triple Play but no SVR.

I started Gilead 7977 and Ribavirin (gonna ask my Doctor what the diff is btw 5885 and 7977), with great results.  <49 at day 3, <25 at day 6.  Started 3 weeks ago Friday.

Check some of the other posts on the site, good info for all.  You can serch for 7977 for a few others who are on or were on 7977.



__________________

ScotU - Age 61, Geno 1A, Diagnosed 1999. Cirrhosis (so no more biospy's), but decent MELD score.  Too many studies, trials, and treatments to remember!  24 Week Harvoni (w/ Ribavirin) Trial - SVR @ 24 Post - 8/28/15
bowens44


Member

Status: Offline
Posts: 7
Date:
Permalink  
 

I haven't posted before but have been an occasional reader.

A little background I have Hep C Genotype 1a. I believe I have had since the late 70s.

First  I was on the interferon ribavirin treatment. I had an initial large drop in viral load but it came back during treatment. I was taken of the meds.

Next  I did the triple therapy interferon, ribavirin and telaprevir . I didn't go undetectable but had a large drop in the viral load but about six weeks in the viral load started to increase and the treatment was stopped.

 

I just finished week 4 of the Gilead Sofosbuvir/GS-5885 trial with ribaviran. So far no side affects at all.

My base line viral load was about 4 and half million. At the end of week one my viral load was <25

and my ALT and AST levels which had been sitting at the high end of normal are now both toward the middle range of normal.

At week 2 I was undetectable and my ALT and AST were both at 13.

I'm trying not to let myself get too hopeful after the previous two failures .......

Maybe this is it. Maybe this is the one.





__________________
Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.
Hep C Discussion Forum -> Clinical Trial Participants -> Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.