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Hep C Discussion Forum -> Clinical Trial Participants -> Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
Post Info TOPIC: Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
mallani


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RE: Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
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Hi Rockyfeller,

Good to hear from you.  You're right about the names- the convention was that all protease inhibitors should end in ...previr, then Gilead comes out with Ledipasvir.  Good luck with your Rx- that's an excellent combo, and retirement will make it even easier.  Keep us posted.  Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Rockyfeller


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Way to go Bob, that is good news.
I did a clinical trial last year, GS 7977, pegasys and ribavirin for 12 weeks, was undetectable for a month, then it came back. Next week I am starting a new trial, sofosbuvir, ledi (whatever) previr (why can't they use names I can pronounce), and riba, for 12 weeks.. I hope to have the same results as you, guess I'll find out in 6 months.

The good part is, I retire on December 16th, so I can take it as easy as I need to whilst trying for the cure. I'm planning on messing around in my sailboat most of that time.

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genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
Tig


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Congratulations Bob! Sounds like you had a long journey, with your share of bumps and bruises. But you got ahead of it and showed it who was in charge this time. It's great to hear it from one of the true HCV warriors! Stay in touch and let us know how your Hep free life treats you. Enjoy it and best of luck!



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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mallani


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Hi Bob,

Great news!  Persistence pays off.  Have a happy HepC-free life.  Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Biggyb


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Great news Bob, very happy for you.



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58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
Cinnamon Girl


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Matt Chris wrote:

Sometimes we can forget how many people visit the HepcFriends web site on a daily basis I don't know the exact numbers but I know they are in the upper 300 people a day and possible a lot more.  (Jill would probably know the exact amount)  The point is, our posts and words can have profound effects on peoples lives now and in the future so please keep it up and keep it real.

matt

 

 Yes, that`s right, Matt.  The number of people who visit the forum each day (members plus unregistered `guests`) is displayed at the bottom of the page, as you know, and it averages at about 350 - 400 in a 24 hour period (I don`t have the exact figures).  I do have statistics showing the number of individual `views` per day though, which is actually much higher, averaging at 3,704 per day! 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
bowens44


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Zlikster wrote:

Hey Bob! SVR IT IS! :)

did u had any sx that you can attribute to DAAs? (since u have experience on Riba sx)

cheers!

None really. I had a little bit of tiredness but I attribute that to the riba,  



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Zlikster


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Hey Bob! SVR IT IS! :)

did u had any sx that you can attribute to DAAs? (since u have experience on Riba sx)

cheers!



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Matt Chris


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Hey Bob

Big Congrats, that is sweet music to my ears and many others that have relapsed and that have been waiting to find a treatment with low effects and high cure rates.

Thanks Bob for getting back to us and giving hope for many hundreds of others.

Hepcfriends  this really illustrates how very important it is that we post are results during are treatment and most importantly after treatment because it can have profound effect on the attitude of HepC patients that are currently dealing with all the physical and Psyche issues that come with the disease.

Sometimes we can forget how many people visit the HepcFriends web site on a daily basis I don't know the exact numbers but I know they are in the upper 300 people a day and possible a lot more.  (Jill would probably know the exact amount)  The point is, our posts and words can have profound effects on peoples lives now and in the future so please keep it up and keep it real.

matt

 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
newmex


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Congratulations!! And Thanks for sharing ,great to hear another positive outcome for those of us getting started or thinking about starting a treatment.Happy Thanksgiving to you and All!



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John
Cinnamon Girl


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Hi Bob, good to hear from you again, that`s great news, congratulations!!  It was certainly 3rd time lucky for you, how fantastic!

You did very well getting onto this trial and what a contrast it must have been from your previous attempts, with few side effects and only 12 weeks of treatment!  You can relax and get on with the rest of your life now, knowing that you`ve finally beaten the virus that`s been lurking for so long!  Thanks for sharing your journey with us, very pleased for you!  smile



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
bowens44


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I haven't checked in in a long time....just got my 6 month post treatment results SVR!!   6 months after treatment the virus is not detected!



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Karen


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Hey Bob...what wonderful news...It is interesting to think about those little virus hiding out somewhere...Lets hope not!



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Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
bowens44


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RE: Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribavirin
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Just a quick update. Week 6 results, all is well.  still undetectable (been undetectable since week 2) , ast and alt still at 12.  HGB is a little low but nothing to worry about or to make me lower my Ribavirin dose.

 

 I have had some insomnia, they gave me a prescription for   temazepam for insomnia, I can sleep now but feel a little foggy in the morning.

No side affects really (other then the insomnia) even with ribaviran.

I am happy (happy doesn't begin to cover it) that I have been undetectable since sometime in week 2 but I'm starting to get nervous. The time to stop the drugs is fast approaching. Three more weeks. I am confident that I will remain undetectable while on the drugs...my worry is what happens when I stop taking them. 

Did I they kill all those little monsters hiding in my blood stream and my organs or are some of them still there skulking in the shadows  , waiting for the day when my protectors , my dragon slayers leave  so that they can reemerge and wage war on my liver once again.

Only time will tell...

 

 

 



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Biggyb


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RE: Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
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Thats awesome news Bob. Keep up the good fight against a evil invader.



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58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
bowens44


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Thanks Matt !

Karen I'm on 12 weeks with riba. It's been a piece of cake so far. Nothing like the misery of the last two attempts.

 



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Karen


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Matt..you are always an inspiration...keep it coming.



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Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
Matt Chris


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Hey Bob, Michael, Scott and Karen

Or should I say The Gilead Band, sounds like you are all singing the same song, and how sweet it is ( Like Jackie Gleason use to say)

It's quite amazing that a group of people that don't really know each other have such a bond together, each of knowing the pain and sorrow of being us.

It's like being a Borg and part of the collective consciousness. (Startrek Character)

Anyway, we of the collective including my tribe the Abbott Labs group are riding a slightly different wave but see the destination very clearly and some have already made it to shore along with some of your group. 

If you have ever been far enough out from the shore swiming in the ocean, there is nothing more motivating than getting closer and closer to reaching the shore and the safety it brings. The great thing about being a collective we have each other to gain encouragment from, to make all the way.

So keep on posting and keep on talking and and keep truckin and we will all make it there.

Matt

image.jpg



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Karen


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Your right...that was the wording.  I actually put n/a...on those questions!  Sure they did not appreciate that..

Yes...24 weeks but no Riba was a blessing.  How about you...see you are w/Riba 12 or 24?



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Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
bowens44


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Hi karen,

I'm in North Carolina. The questions are probaly similar if not the same, they are all about health, mental state etc. It's just the wording that I find a little starnge. 'Has your hep C caused you to miss work?'  I have never really thought of it as 'my hep C'.....

I've never looked at it as something that is mine. To me it's always been something foreign. An invader, a parasite, an evil presence....something to be eradicated, expelled, defeated.....this is my third attempt in about 6 years, I hope it's the final battle. 

 

You're on for 24 weeks?

Good luck! I wish you the best.



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Karen


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Hi Bob,

Congrats..on your results!

Started this trial last Tuesday w/o ribaviran.

I had questions to answer but they were more about my mental and physical state.  Where are you doing this trial?   Seems like the questions would be standard/routine.

I will be posting on "A journey through the twists and turns of Sofosbuvir/GS-5885 Fixed-Dose Combination ± Ribavirin".  Keep us posted...good to have someone else on the forum going through the same treatment.



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Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
bowens44


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Checking back in. Just finished week 6.

Week  4 results:

Viral Load: undetectable

ALT 12

AST 12

HGB 14.4

Good luck to those getting into this trial. Hopefully we can beat this thing..... 

On a side note, some of the wording of the questions that are asked really bother me.

Especially when the question begins 'Has you Hepititus C.....' They make it sound like its something I went down to the local Walmart and purchased. 'Yes give this pair of jeans and apple ...and oh yes, do you have any Hep c?'

This isn't MY hep c, this is an invader who is waging a war on MY liver...... 

 

 

 

 

 



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Karen


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Went Thursday for my screening on this study...Have my fingers crossed that I pass go!  If all is good, I start in 26 days. 



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Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
gsx1250fa


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Good luck! I finished up this 12 wk arm 3.5 weeks ago. I went und at week 4. My 2 week post Tx draw was und. Had my 4 week draw (5 days early) yesterday. I am a 3 time Tx attempt/failure with early stage cirrhosis. Hopes and prayers :)



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scotu


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That's great news!  Good luck and keep up the good work.

I have a history that sounds similar to your's...  Geno 1A, Probably got HEP C from 1972 Blood received for motorcycle accident (badly broken leg), 1st noted a Liver problem in the early 80's, but they couldn't spell HEP C in those days.  Finally diagnosed in 1999.  Been on many treatments, including Undetecatble at all keep checks on the Telaprevir Triple Play but no SVR.

I started Gilead 7977 and Ribavirin (gonna ask my Doctor what the diff is btw 5885 and 7977), with great results.  <49 at day 3, <25 at day 6.  Started 3 weeks ago Friday.

Check some of the other posts on the site, good info for all.  You can serch for 7977 for a few others who are on or were on 7977.



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ScotU - Age 61, Geno 1A, Diagnosed 1999. Cirrhosis (so no more biospy's), but decent MELD score.  Too many studies, trials, and treatments to remember!  24 Week Harvoni (w/ Ribavirin) Trial - SVR @ 24 Post - 8/28/15
bowens44


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I haven't posted before but have been an occasional reader.

A little background I have Hep C Genotype 1a. I believe I have had since the late 70s.

First  I was on the interferon ribavirin treatment. I had an initial large drop in viral load but it came back during treatment. I was taken of the meds.

Next  I did the triple therapy interferon, ribavirin and telaprevir . I didn't go undetectable but had a large drop in the viral load but about six weeks in the viral load started to increase and the treatment was stopped.

 

I just finished week 4 of the Gilead Sofosbuvir/GS-5885 trial with ribaviran. So far no side affects at all.

My base line viral load was about 4 and half million. At the end of week one my viral load was <25

and my ALT and AST levels which had been sitting at the high end of normal are now both toward the middle range of normal.

At week 2 I was undetectable and my ALT and AST were both at 13.

I'm trying not to let myself get too hopeful after the previous two failures .......

Maybe this is it. Maybe this is the one.





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