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Tig


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RE: Low platelets and studies
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Thanks for that information Mallani. That was very helpful!



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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mallani


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Low platelets are common in cirrhotics and especially during Rx. At 48 weeks my platelets were down to 38,000 ( normal range 150,000- 400,000). Before Rx, my platelets were 185,000. Low platelets are not really a problem, unless you like playing with sharp knives. If your doctor is worried, you can get a transfusion of platelets or use a drug like Promacta.

White blood cells will drop due to bone marrow suppression from Riba and Peg. The neutrophil count is the only important one. I dropped to 0.7 and some have dropped to 0.5 Again, this is not a big deal, but drugs like Neupogen will cause rapid rise in Neutrophils.

Low Hb and RBC'c are often treated by lowering the dose of Riba. Blood transfusion may be needed for severe cases, and Procrit is often prescribed in the USA when the HB drops below 10. I dropped to 7.1 which made life difficult, but I was almost back to normal(16.5) 8 weeks after Rx finished.

How you're managed depends on your doctor. Rx has been stopped in many cases.



-- Edited by mallani on Sunday 23rd of June 2013 03:29:26 PM

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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Tig


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I understood that there is a medication available to boost WC production. My doc mentioned to me that should my WC level plummet and throw me in an anemic tail spin, he would admit me long enough to get a blood transfusion.  I had trouble with that the first time, 16 years ago. I was stopped back in that day.



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Biggyb


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Hi JLynch30, all i know is live with it.

My GI told me even if i get SVR, my platelets will probably always be low.



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58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
JLynch30


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Hello,

Does anyone have information about how to manage low platelets and if there are any new studies going on for no responders? 

 

Thanks.



-- Edited by JLynch30 on Monday 17th of June 2013 10:48:10 PM

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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
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