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Hep C Discussion Forum -> On Treatment -> 4 week VL
Post Info TOPIC: 4 week VL
nurschic


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Date:
RE: 4 week VL
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Thanks Toni.....Your doing great too! Im starting to get run down a bit easier here the last week. Seems like after my 2nd day of work Im about ready to sleep the minute I get home. Trying to stay up till after 9pm is getting harder and harder, but I have to stay up in order to take my meds. yawn



__________________

Dx:2007; Genotype 1; VL 1.4mil, start triple therapy (peg/rib/inc) 6/2/13 (Failed), Harvoni 12 weeks EOT undetected, 6 month EOT UNDETECTED!
tonib


Senior Member

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Posts: 188
Date:
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Way to go gf!  I am thinking you are doing so great, and now you are on your way to HCV freedom!  I am praying for the shortest therapy for you!  



__________________

 geno 1, started peg and riba 7/5/13, now 29th day is vicrellis ***tonib VL started 6 million, after 5 weeks 374,000, after 8 weeks 150,000....the big test for VL is 9/27 at 12 weeks  TAKEN OFF THERAPY JUST NOT WORKING FOR ME...12 WEEKS STILL HAVE 9000 VL
nurschic


Senior Member

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Well... I just got my 8 week labs work back (a bit early), but there is not a VL at this time. Looks like I am holding strong in my counts.... Only 4 more weeks of the Incivek and to the next VL.....PLEASE PLEASE PLEASE let it be UND!!!! (Please?!?!?!)

 

 

 

Start

2 Weeks

4 Weeks

8 Weeks

 

May 6, 2013

Jun 17, 2013

Jul 1, 2013

Jul 23, 2013

WBC

8.4

6.2

7.4

4.6

Plat

325

301

282

257

Neut

72

72

80 H

67

HGB

16.3 H

14.3

13.7

13.8

HCT

47.4 H

42.7

42.1

41.4

 

 

 

 

 

TSH

0.533

0.799

0.961

0.899

T4

1.39

10.0

1.05

1.05

 

 

 

 

 

Protein

7.4

7.2

7.0

7.0

Albumin

4.8

4.4

4.4

4.4

Bili Total

0.4

1.2

0.7

0.5

Bili Direct

0.13

0.29

0.23

0.16

AST

31

29

32

34

ALT

53 H

42 H

58 H

52 H

 

 

 

 

 

HCV Quant

1,436,530

 

367,580

 

HCV Log10

6.157

 

5.565

 

 

 

 

 

 

Ferritin

 

225 H

 

140

TIBC

 

344

 

379

UIBC

 

130

 

314

Iron Serum

 

214 H

 

65

Iron Sat.

 

62 H

 

17

 



__________________

Dx:2007; Genotype 1; VL 1.4mil, start triple therapy (peg/rib/inc) 6/2/13 (Failed), Harvoni 12 weeks EOT undetected, 6 month EOT UNDETECTED!
ucbgal


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Posts: 297
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ranelle,

     you are a fighter and are doing the best you can. stay strong & keep the faith. looking at your mini-chart there's improvement. my dr. always says it's just a #,it goes up&down at it's will. our viral loads evidently go through cycles.

     just out of curiosity do you know your uric acid levels? unfortunately mine are going up due to the meds. my dr. said it's normal and the clinical trials show that 73% of us get this.

sandy,ucbgal



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nurschic


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This is what my lab work trend looks like: My MCV is high @98 and my lymphs are low @12......I do not know what my uric acid levels are. All I can say now is.. COME ON 12 WEEKS!

 

 

Start

2 Weeks

4 Weeks

 

May 6, 2013

Jun 17, 2013

Jul 1, 2013

WBC

8.4

6.2

7.4

Plat

325

301

282

Neut

72

72

80 H

HGB

16.3 H

14.3

13.7

HCT

47.4 H

42.7

42.1

 

 

 

 

TSH

0.533

0.799

0.961

T4

1.39

10.0

1.05

 

 

 

 

Protein

7.4

7.2

7.0

Albumin

4.8

4.4

4.4

Bili Total

0.4

1.2

0.7

Bili Direct

0.13

0.29

0.23

AST

31

29

32

ALT

53 H

42 H

58 H

 

 

 

 

HCV Quant

1,436,530

 

367,580

HCV Log10

6.157

 

5.565



-- Edited by nurschic on Friday 12th of July 2013 01:50:23 AM

__________________

Dx:2007; Genotype 1; VL 1.4mil, start triple therapy (peg/rib/inc) 6/2/13 (Failed), Harvoni 12 weeks EOT undetected, 6 month EOT UNDETECTED!
mallani


Guru

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Posts: 3398
Date:
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Hi Ranelle,

Sorry about your 4week VL, but wait until the 12 week one.  As you said, if you are Det. with a VL of > 1000 at 12 weeks, Rx is discontinued.  From the early Trials, 60-70% of patients achieve RVR (Undet. at week 4) and another 10% are undet. by week 12.  That means 70-80% of patients are Undet. at week 12, and of these, 95% go on to SVR.  However, current policy is to treat the Det. at 4 weeks for 48 weeks, rather than the 24 weeks for the eRVR's. So you've still got a good chance, but will probably do 48 weeks. Good luck!



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Kellie


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Hi Ranelle, hang in there with the treatment as it's having an effect on your vl. My doc told me that week 12 is the defining week. Just keep on fighting and keep those positive thoughts going. Kel



__________________

HCV 1A 1980. Dual tx 2003 -UND at wk 11-discontinued due to severe depression

Started Triple 4/16/13 for 24 weeks

UND wk 4,6,8,12,17 & 24

E.O.T. 9/29/13

EOT + 12 weeks=SVR, and EOT +26 weeks=Cured!
Biggyb


Guru

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Date:
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Good Luck nurschic, Were all here in your corner no matter what. Your one of us and we stick together. Keep fighting..



__________________

58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
britlitkaren


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I love your attitude! I have a friend who is in limbo with VL. I hope you get an answer soon. For sure your liver is getting a break right now. That is definitely good news.
xoxo Karen:)

__________________
Diag 8-10. 1st VL 600,000. Gen 1a. Grade 4 Stage 4 cirrhosis w/ Esophogeal varices level 2. Viral load 1,750,000 7/12/10. Triple Therapy w/ Telaprevir began 7-15-11
nurschic


Senior Member

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Posts: 143
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Thanks everyone! Im too bullheaded to give up the fight this quickly! I would have fought tooth and nail to stay on treatment! Im wondering if my VL levels have to do with my high iron levels that I have been having. I read that iron will interfer with the interferon. I will have my iron levels rechecked at week 8. At least my levels are going down and not staying steady or increasing, guess I will take the 367,580!



__________________

Dx:2007; Genotype 1; VL 1.4mil, start triple therapy (peg/rib/inc) 6/2/13 (Failed), Harvoni 12 weeks EOT undetected, 6 month EOT UNDETECTED!
tonib


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Posts: 188
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I am sorry you did not get the news you were hoping for, but your chance of beating this is good.  Keep fighting!  I am thinking of you now and sending you good wishes.  Remember to take 1 day at a time, and the day will come to be HCV free!!



__________________

 geno 1, started peg and riba 7/5/13, now 29th day is vicrellis ***tonib VL started 6 million, after 5 weeks 374,000, after 8 weeks 150,000....the big test for VL is 9/27 at 12 weeks  TAKEN OFF THERAPY JUST NOT WORKING FOR ME...12 WEEKS STILL HAVE 9000 VL
edmed


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nurschic wrote:

 The fact sheet for incivek says that if the lab values are equal or greater then 1000 IU that SVR is unlikely and that treatment should be discontinued. I'm not really to give up this fight..... I'm just not! Guess ill just have to wait to see what my Dr has to say......

 Hi nurschic, I've  had the same conversation with DR before and after my 4wk, 8wk and 12 wk. At 12 wk i still tested at #261 which is under 1000 and after a little bit of getting enrage, upset, disappointed and wanting to stop TX I finely understood how important it is to continual and never never give up hope. Here I am, now at wk #19 and its gotten  a whole lot better with SX and I know i can make it to where ever this TX take me. good luck and keep posting on how your TX is going.



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Cinnamon Girl


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Great, I`m glad your doctor replied so quickly!  You`re still in the running, let`s hope for the best then!  Keep going...  smile



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
nurschic


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Posts: 143
Date:
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Well..... My Dr wants to keep me on treatment and see what my 12 week labs say. He said we will make treatment decisions at that time. 



__________________

Dx:2007; Genotype 1; VL 1.4mil, start triple therapy (peg/rib/inc) 6/2/13 (Failed), Harvoni 12 weeks EOT undetected, 6 month EOT UNDETECTED!
lucy


Senior Member

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Posts: 115
Date:
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Hi, nurschic, keep fighting. we are all here with you.



-- Edited by lucy on Thursday 11th of July 2013 01:27:46 AM

__________________

 1b, start triple treatment(incivek) on Feb 5, 2013.  UND@ 4,12,24 wks. EOT Aug 6, 2013
nurschic


Senior Member

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Posts: 143
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I emailed my Dr to see what the action plan is. The fact sheet for incivek says that if the lab values are equal or greater then 1000 IU that SVR is unlikely and that treatment should be discontinued. I'm not really to give up this fight..... I'm just not! Guess ill just have to wait to see what my Dr has to say......



__________________

Dx:2007; Genotype 1; VL 1.4mil, start triple therapy (peg/rib/inc) 6/2/13 (Failed), Harvoni 12 weeks EOT undetected, 6 month EOT UNDETECTED!
Dillo


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I thought I saw Malcom post some of the treatment data on Incivek here but can't find it. Just because you get a UND at 4 wks doesn't mean you won't get a viral breakthrough between 12wks and EOT  (defined as someone whose Hep C virus is detected before the end of treatment) and doesn't guarantee a SVR. Unfortunately for all of us there are no guarantees. What it could mean is your treatment may be longer according to what your Doctor decides you should do. Usually being detected at 12 wks is a major factor in treatment.

 



__________________

GT 1a Started triple tx with Incivek, Pegasys, and Riba 2-6-2013. UND at 4,6,12,23,& 24 wks EOT 7-26-2013. Probably had Hep C for 20-30 years. Don't really know when I got it.

nurschic


Senior Member

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I'm on Incivek and had my 4 week VL done on the first. I'm kinda discouraged cause I did not come back UND, instead my VL is 367,580. What is the success rate of people on treatment that dont have EVR?



__________________

Dx:2007; Genotype 1; VL 1.4mil, start triple therapy (peg/rib/inc) 6/2/13 (Failed), Harvoni 12 weeks EOT undetected, 6 month EOT UNDETECTED!
nurschic


Senior Member

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Posts: 143
Date:
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My Dr is awesome when it comes to getting back to me! I'm glad he didn't want to take me off treatment. He said he wanted to keep me on because I have been able to handle it so well so far, And because I had a very large drop.. The fight is still on!



-- Edited by nurschic on Wednesday 10th of July 2013 07:24:39 PM

__________________

Dx:2007; Genotype 1; VL 1.4mil, start triple therapy (peg/rib/inc) 6/2/13 (Failed), Harvoni 12 weeks EOT undetected, 6 month EOT UNDETECTED!
Cinnamon Girl


Guru

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Posts: 5629
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Yes, I know, Ranelle, and I really didn`t want to tell you that, sorry.  See what your doctor says anyway, and let us know.  You`ll win this battle one way or another.  Best of luck...



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Cinnamon Girl


Guru

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Posts: 5629
Date:
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Hi Ranelle, sorry you didn`t get the result you wanted.  i think the best thing now would be to speak to your doctor about your viral load and see what he wants you to do.  Take care, wishing you all the best. smile

 



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
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