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Hep C Discussion Forum -> General Discussion -> % Rates of people who complete treatment
Post Info TOPIC: % Rates of people who complete treatment
mallani


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RE: % Rates of people who complete treatment
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Daa's= Direct Acting Antivirals. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
dustbear


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DAA's?



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Geno 1A, since 1981. SOT 1/2013   TX stopped 11/2013 in week 45/48 due to Myositis & Interstitial Lung Disease. Completed 94% of Peg-Inter dbl TX, UND since week 4.  SVR 4/2014!  Still SVR after 4+ yrs!

"Day by day, step by step, breath by breath"
mallani


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Hi Timothy,

This has been the subject of many papers. It seems to depend on age, amount of liver damage, genotype, socio-economic group, drugs used, and length of Rx.  Psychological and physical side effects account for most of the failures to complete Rx, together with those who have to finish Rx due to poor response. Pre-existing conditions, such as diabetes, mental problems etc. increase this number.

The highest rate is in cirrhotic, older patients with Geno 1 or 3. Since the introduction of the antiproteases, the number of Geno 1's who drop out, has increased markedly. My doc showed me a survey where 45% of Incivek patients failed to complete the course, compared to about 25% of the Victrelis patients. There has been wide variation in surveys, as you would expect, but the range of drop-outs is between 15 and 50%. With the new DAA's, one would hope this figure will drop dramatically.

Patient education, full pre-Rx evaluation, and the skill/experience of the Hepatologist all play a significant role.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
rotting to the core


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Being as to how I am starting my 40th week of treatment, I can't help but be curious as to how many people have been able to succeed in completion of of treatment. What I have found suggests it is less than 25%. Of course that is an old study done by the VA many years ago. Does any one have more current information? confuse

I have always heard many can't tolerate treatment for many reasons, I am so grateful for my support system, with which I could never have made it even this far. smile

Tiomthy



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Timothy

GT3a Baseline VL 514,000, Week 4 VL 130, Week 12 UND and have been UND ever since.  

Completed 48 week of Pegasys & Copegus. EOT VL UND.   Achieved SVR after 48 weeks of treatment.                                                   

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