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Hep C Discussion Forum -> Hep C News -> First study of benefits of SVR using triple Rx
Post Info TOPIC: First study of benefits of SVR using triple Rx
Zlikster


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RE: First study of benefits of SVR using triple Rx
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Hi Malcolm,

scary topic indeed. Speaking of hidden virus remains, have you managed to find out in what Pathology issue was that case presented for HCV "leftovers" in different tissues and organs postmortem?

cheers



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
mallani


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Hi Matt,

'Occult HCV infection' is a scarey topic. It basically means detectable HCV in the liver and blood monocytes ( using high resolution assays), in the presence of Undet. blood HCV. I have done previous posts relating to SVR, and possible persistence of tiny amounts of virus in the body. This term is fairly new, and has been found in two situations.

1. Apparently healthy people may have 'occult HCV infection'. They may be HCV Antibody -ve, have an Undet. VL, have normal or abnormal LFT's and have no hepatitis risk factors. The virus may be any Genotype.  They are true 'carriers'.  Obviously, screening of blood donors remains a slight worry.

2. HCV patients who have been treated and achieved SVR, still have a tiny chance of relapse. This may be due to re-activation of remaining rests of virus, in the liver, monocytes and possible other organs.

I hope this will be clarified by more research.

Previous studies of SVR were only on patients who had used Peg and Riba. Mutations were not a concern.  Now, with the DAA's, RAV's are a new topic. That is why this is an interesting article. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Matt Chris


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Hello Malcolm 

Thanks for that link about the durability of triple therapy after achieving SVR.

Both my trial doctor and my new Hepatologist  thinks there is a place for a Interferon type product (immune system booster) with HCV treatment especially with cirrhotic patients, to help them fight any left over (hiding) HCV with long term treatment.

This report did mention something I read before that I know very little about that is the term "occult HCV infection" I assume that it's means an undiscovered type of HCV that they have not yet identified.

Malcolm do you have any insight on that?

Matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
mallani


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Hi all,

There have been countless studies reporting the results of SVR using Peg. and Riba. This is the first report I have seen of the SVR benefits using triple Rx. As DAA's have only been around for a short time, obviously the numbers are small, but the results are reassuring.

 

http://www.natap.org/2013/HCV/073113_04.htm



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
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