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Post Info TOPIC: 8th week peg and rib anybody close?


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RE: 8th week peg and rib anybody close?
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Thank you again. I long for the day this side effect wears off. I keep telling myself it's the Meds. And just stop making words, even in my own head I detest "shut up"! Hey thank you. It's nice to have somebody to bouce stuff on. Seriously, sums up my life in one word. :)

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Tig


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Well the Rage is a real problem all by itself! It can be mild, moderate or massive furious I think it's difficult to say how you'll be affected on any given day, but it's safe to say it can affect you at any moment. My best suggestion is to know your limitations and since you've been on Tx for several weeks, you have an idea of those moments or triggers that will likely set you off and do your best to avoid them. I realize that it's impossible to avoid everything. Facts prove that you'll have to deal with some anger or rage from this stuff and your best method to handle it is to remove yourself from the offending person or environment as soon as you can. Listen to music, meditate, exercise or try some Yoga. Just try something and often the change of activity can defuse the moment of rage. I can feel it brewing and have learned to recognize it. I must admit though that I have taken the opportunity to let a person or two know what I was thinking, but only on a rare occasion. It's best to just avoid confrontation, especially when the causative factor lies within a small blue pill called Ribavirin...



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Thanks, it's encouraging. Any suggestions on Rib Rage? I work 8 to 5. Seems worse 4-8, also very busy time of day for me. I normally take rib 6 am and 8 pm.

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Tig


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That's excellent news! So glad that you're UND at 8 weeks, that's a very good indication of future SVR success. It also sounds like your doc made the right call regarding your glucose results. Just keep an eye on all of your tests in the future and be involved. Everything is moving forward on schedule and moving very positively! Keep us informed of your future progress and take a moment to do a Happy Dance, you deserve it after good news like that! biggrin



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Thank you all. I just left GI Doc and he said I am untracable after 8 weeks. He said my Glucose numbers are not high enough to worry about until I am finished the treatments in January. He also said the side effects, although he wouldn't guarantee it have peaked at this point. 18 weeks to go.

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Hi Cinders,

Tig has a good point. As is often the case, I have problems with USA lab. values. You state that your non-fasting glucose was 109 mg/dL. The USA normal range for non-fasting is stated as 70-120 mg/dL (3.6 -7.5 mmol/L here and in Europe), so yours is normal. Your HbA1c is slightly elevated at 6.7%, where <6.5% is accepted as normal. The HbA1c measures glycated haemoglobin, which is an indication of average blood glucose over a long period of time. I certainly would refuse Diabetes treatment with those levels.  You need to get a fasting blood glucose and insulin.  Insulin Resistance (IR) is common in HepC, and is associated with a poorer response to Rx and to a more rapid increase in liver fibrosis. Even high blood sugars without IR, can be found in Chronic HepC.  This usually settles down after SVR, which you will almost certainly achieve.  Please let us know when you get the fasting results. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm

Tig


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Seriously, welcome to the group! I'm glad you're checking because you may have a question or two for your doctor. First of all your glucose level was stated as non fasting. All glucose levels to diagnose diabetes should be drawn after fasting! Yours was 109 and you weren't fasting! The chance of your test being elevated following a non fasting draw is very high! My nurse ordered a non fasting glucose level and it came back elevated (118). Then I had it done fasting and it was 109. High normal is 99. Your Hb A1c is elevated. But were you taking these meds when that was done as well? Normally you would follow up those results with the appropriate specialist, but this isn't a normal set of circumstances. My Hepa said it was nothing to worry about because as Jill mentioned, these meds can cause those numbers to fluctuate, wildly sometimes. I have had additional tests done with similar results. My doc said as long as those results continue to stay only mildly elevated, he isn't going to worry about it. Why? Because these drugs alter those test results. I would seek an additional opinion by a Hepatologist familiar with these medications before starting treatment for diabetes based on those numbers. Chances of those results returning to normal following treatment are quite good. 



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Hi again, thanks for that information.   Type 2 diabetes is known to be associated with Hep C and sometimes the treatment drugs can make it worse, so maybe that`s why it`s shown up now.   I`m certainly not an expert but your glucose levels don`t look too bad at all.

Your viral load was in the low range to start with.  Did you have another viral load test done at week 4?  Your ALT and AST levels are great! 

I`m sure it must be hard going for you with your grandchildren to care for, but hang in there and hopefully things will start getting easier for you.  smile

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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I just had blood work on Friday and now the primary says I have Type 2 diabetes and wants me to start treatment. My Glucose on a non fast test was 109. My ALT 20, AST 27, HBA1C 6.7. Does this make any sense? Thank you for responding. Viral load at beginning was almost 700,000. But I don't remember the AST or ALT.

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48 year old raising 3 grandchildren with SO.  He was diagnosed with Hep C geno type 1 and went through treatments that pretty much rendered him useless.  I get tested, well cause we've been together 20 years and I have it too, just geno type 2.  Docs were confused we were confused. Viral load  close to 700,000.  Pega injection Thursdays and 400 rib twice a day.

Side effects, short term memory loss, very easily bruised. minimal joint pain day of shot and shear exhaustion the day after and I feel like I am growing rocks in my nose (this is the worst).  Exhausted and SO thinks somehow my treatment isn't as bad as his cause I am not taking inciveck. 

 

I go to my primary because of my nose it hurts.  She sees the bruises and sends me for blood work STAT.  I am a hard stick and I was told to drink and eat chips or something salty that it helps.  I drank an apple juice and a bag of chips on the way to hospital for STAT blood work.   Now she has called in a prescription for more pills, says she thinks I must be pre-diabetic.  None of the blood work makes sense. 

 

Can anyone shed light on this?

 



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Hi Cinders, welcome.  Sorry to hear you`re having such a rough time on treatment.  I`m not sure I can give you an explanation for everything you`ve told us, but there are a couple of points I can help you with. 

First of all, if you`ve been diagnosed with gen 2 and your SO has gen 1, then it means you were both infected separately from different sources.  You always have the same genotype as the person who you caught the virus from, and that doesn`t change.

Secondly, how people cope with Hep C treatments varies a lot from person to person, and the side effects from the double combo of Peg and Riba can be very hard going for some, and certainly no walk in the park.

So, do you have any blood results you can share with us, please?  It`s difficult to say much more without having any more information to go on.

Wishing you all the best.



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 

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