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Post Info TOPIC: Anyone?


Guru

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RE: Anyone?
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Hi John,

6 months will be fine. Make sure they do the followup on the same machine. Relax. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Thanks!  They want to do it again in six months - should I push for three? 

I do feel some "new" pain in the liver area but not related to this.

 



-



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



Guru

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Hi John,

Thanks for the report. I'll try to be careful in giving my personal opinion. My report would be 3 times as long.

Interestingly, your lesion is in segment 2 of the L. liver lobe, same as mine.

The report mentions that the lesion was present on the previous scan of 28th June but 'less conspicuous'. This is a relief!

The lesion is 'mildly lobulated', and shows 'peripheral globular enhancement'.

No mention is made of a central scar, or washout. Boy, 27 mls of MagneVist is a lot of contrast- I weigh 78 kg, and get 23 mls!

Opinion: I would be fairly confident this is benign, and is either an haemangioma, adenoma or FNH (Focal Nodular Hyperplasia). I base this on the fact that you had a big dose of contrast, and a 1.7 cm HCC would show more enhancement as they derive a rich blood supply from the hepatic artery. I would want a followup in 3 months and ask for a comment about washout.  Just my opinion mate.  Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm

Tig


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If you're interested in a file download that will allow you to convert your TIFF files to other formats (JPEG) this has been around for a long time and is free. Check it out!

http://download.cnet.com/IrfanView/



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Yeah it is saying file too long when I try that!



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



Guru

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Hi John, if you`re having trouble attaching the file, maybe you could try taking a screenshot and posting that? 

 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Not sure if it is going through - I can't seem to attach it.  I have it as a word file and a tif file - I can't save it as a jpeg. 



-- Edited by JLynch30 on Wednesday 27th of November 2013 10:00:21 PM



-- Edited by JLynch30 on Wednesday 27th of November 2013 10:24:18 PM

__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



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I have attached the report! 



-- Edited by JLynch30 on Wednesday 27th of November 2013 10:03:20 PM

__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



Guru

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Just the report John. There will be hundreds of images, even though there is usually just a selection on the CD. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Yes it was an injected dye MRI in the loud tube.  Sorry for the mix-up.  The lesion did not show up  on the first one but she thinks they missed it and that in her opinion it this is a benign lesion.  I would be happy to send over my pictures to you when I get the disc on Wednesday.  Should I attach them here? 



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



Guru

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Hi John,

MRI and CT scans are very different.  I'm surprised you didn't know it was an MR as on 23May you posted 'They are going to do an MRI. I just had one 2 months ago.....' . For an MRI you are in a sealed room in a tunnel, with space-age music as the machine runs through each sequence, and the examination takes about 40 minutes.

Radiologists have their own preferred imaging modalities. I prefer MRI provided the required sequences are done after the IV contrast.  I would be interested to read your report.  I hope they compared it with the previous MRI. If it was reported as an haemangioma, your doctor must be nuts to be discussing Rx options for HCC with you. Good luck.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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so I just found out it was an MRI with contrast I had done where the radiologist said it was a benign lesion. Is this better than a ct scan?   I am getting the results on disc on Wednesday.   



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



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Okay I think you just answered my question.  Thanks.



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



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  The radiologist thinks it a benign tumor and to "not be concerned"  - the Dr. wants to show it to the other liver doctors at the board meeting next week.  It is a 1.7 cm lesion that they said they don't treat until it is 2 or over.  The three options if it is cancer is cut it out, freeze it or liver transplant.  My question is if the radiologist says do not be concerned it is benign then whey is my doctor telling me about cancer options? jeez.



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



Guru

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RE: Anyone?
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Hi again John,

That would be 1.7 cm as lesions measuring 1.7 mm can't be distinguished. From your previous posts, I see you had an MRI in about March 2013, as you had a slightly elevated AFP. Ask your doctor whether this has been compared with your recent CT. The good news is that it is a single lesion.

The doubt might be arising from the fact that they may have just done a standard CT.  In these, only arterial and venous phase scans are obtained ( after the injection of I.V. contrast).  As I said before, only a delayed scan can reliably tell the difference between an HCC and haemangioma. An HCC washes out ( i.e. the IV contrast is gone) quickly, whereas an haemangioma stays bright (i.e. containing IV contrast). I had the same problem when I had my first CT in 2002. I was unhappy with my Ultrasound results as my liver is high under the diaphragm, and I felt I could only see ~80% of the liver clearly.  I went to another Radiology practice and had a routine scan, and deliberately didn't look at the films. I then had a call from the Radiologist ( the same day) to go back for another CT, this time with delayed films, and a larger dose of IV contrast.  Like you, I was freaking out.      I had the repeat scan then saw the problem. I had a 1.1 cm round lesion in segment 2 of my L liver lobe.  On the previous scans, it could have been an HCC.  However, after the second scan, it didn't wash out, so we could be 99% certain it was an haemangioma.  Several MRI's and CT's ( and 11 years) later, it now measures 1.2 cm and is obviously a typical haemangioma.  It it still extremely difficult to see on Ultrasound and often can't be seen at all.  If I were you, I'd ask for a comparison with the MRI, then a repeat CT with delayed films. You shouldn't be messed around like this. Again, sorry to be technical, but there's no easy way to describe this. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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I just got off the phone with the doctor - he said it is 1.7 cm or mm or whatever and that right now it looks like it might be a benign hema but that he needs to show it to more radiologists.  Then he went into the cancer talk - what the plan would be and whatever.  Jeez I am freaking out here.



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



Guru

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Guys,

Please, please, no more Dr.M's. I'm just another grateful Forum member. Thanks.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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How fortunate we have you Dr. M!
Xxoo

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JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!



Guru

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Hi John,

Yes, it does. They'll probably do a followup, just to be certain. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm

Tig


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We most certainly are fortunate to have him on our team! I couldn't agree more, his knowledge and willingness to share it is so appreciated and valued. Thanks just isn't enough, but he needs to know ours is genuine!



-- Edited by Tig56 on Friday 22nd of November 2013 08:05:08 PM

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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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I can't thank you enough for your responses - you are btter than my doctors at explaining things to me in a clear, concise manner.  You are a Godsend!



-- Edited by JLynch30 on Friday 22nd of November 2013 01:04:51 AM

__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



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Does this mean if the riadioligist called it a haemNGIOMA it probably is?



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



Guru

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Hi John,

On a modern multislice CT machine, HCC should be easy to differentiate from haemangioma in 98% of cases. Both lesions appear hypodense on a non-contrast scan.  After a bolus of I.V. contrast, arterial phase images show intense filling-in with HCC, and peripheral filling in with an haemangioma. On portal phase slices, HCC's show early washout with the lesion becoming rapidly isodense or hypodense.  Haemangiomas show very slow washout, and usually show retained enhancement on the delayed films. In cirrhotics, regenerative nodules are more difficult to diagnose. These may appear similar to an HCC, and often followup is required.  I know this is very technical, but 'wondering if it will grow' doesn't sound very enlightened.  Actually, MRI is easier for sorting out small liver lesions, with the new sequences and liver contrast. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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It might not be that after all they are wondering if it will grow in 3 months.  It might be a small HCC 



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



Guru

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Hi John,

Liver haemangiomas are common, and are often found on routine Ultrasounds, CT or MRI examinations of the liver.  They are usually between 1 and 3 cm in diameter, and are vascular, congenital tumours. They very, very rarely cause problems, and they have a distinct vascular pattern after I.V. contrast on both CT and MRI. The main thing is to distinguish them from a small HCC.  I have one in Segment 2 of my L liver lobe and it has not changed in 10 years. Don't worry about them. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Has anyone heard of benign hemangioma?  I think one came out on my ct scan

 



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 

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