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Hep C Discussion Forum -> General Discussion -> HCV direct-acting antiviral agents: the best interferon-free combinations
Post Info TOPIC: HCV direct-acting antiviral agents: the best interferon-free combinations
Zlikster


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RE: HCV direct-acting antiviral agents: the best interferon-free combinations
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cheers Matt! :)



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Karen


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Matt..Thanks...Interesting read



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Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014
lauralou57


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Great article! Thanks for posting.



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mallani


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Thanks Matt. Good summary.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Matt Chris


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Hey all

Thought this was a easily understandable article from Liver International ISSN about the current DAA's that will be coming to market in the next year.

Remembering all the DAA's and what part of the protein they inhibit (whether they are a NS5a or NS5b , NS3, etc) is always confusing. This article helps  a lot and give trials results that have been disclosed before but in one read.

Here is a small excerpt :

Viral replication cycle and targets for drug development

The HCV replication cycle begins with virion attach- ment to its specific receptor. The HCV RNA genome serves as a template for viral replication and as a viral messenger RNA for viral production. It is translated into a polyprotein that is cleaved by proteases followed by viral assembly. 

Follow this link to read.  Once there then scroll down to abstract and then on bottom right hit (get PDF )

http://onlinelibrary.wiley.com/doi/10.1111/liv.12423/abstract

 

Matt

 



-- Edited by Matt Chris on Wednesday 8th of January 2014 07:18:17 PM



-- Edited by Matt Chris on Wednesday 8th of January 2014 07:23:18 PM



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