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Hep C Discussion Forum -> On Treatment -> Would those taking off-label Sovaldi/Olysio with or without Riba mind posting here?
Post Info TOPIC: Would those taking off-label Sovaldi/Olysio with or without Riba mind posting here?
Gator Man


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RE: Would those taking off-label Sovaldi/Olysio with or without Riba mind posting here?
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Great news Mac! Rob has helped a lot of people on the forum in many ways, not the least of which is the positive attitude he's maintained throughout his own tx. It's contagious in a good sense and I'm glad he and the rest of us were there for information and encouragement. Good luck!



__________________

Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Groupergetter


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Hey Mac, congrats on finishing your treatment.  smile

 Good to get it behind you.  Hope and pray you get SVR. 



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
Tig


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Dzdayscomin wrote:
Fireman Rob wrote:

Hi Mac,

I'm glad to see my posts helped you. I'll keep my fingers crossed for you when we're doing our 12 week EOT labs two weeks apart. Welcome to the forum. I'm so glad you decided to post. Good luck!

-Rob

 Can always count on a Fireman!

biggrin

 Amen to that Duane!! God bless all First Responders  

Tig



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Dzdayscomin


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Fireman Rob wrote:

Hi Mac,

I'm glad to see my posts helped you. I'll keep my fingers crossed for you when we're doing our 12 week EOT labs two weeks apart. Welcome to the forum. I'm so glad you decided to post. Good luck!

-Rob

 Can always count on a Fireman!

biggrin



__________________

53yr M 1a acq 12/83 cirr pre tx MELD 17  tx nv diag 1/29/12  tx S/O 3/5/14  trans list.

EOT 5/28/14 UND 6/12/14 SVR 8/29/14 MELD 14 dx HCC 9/5/2014 tumor ablation 9/24/14

In the 10K lakes State It's not about us but those around us.
Fireman Rob


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Hi Mac,

I'm glad to see my posts helped you. I'll keep my fingers crossed for you when we're doing our 12 week EOT labs two weeks apart. Welcome to the forum. I'm so glad you decided to post. Good luck!

-Rob



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Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!
Tig


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Hi Mac,

Welcome to the forum! I'm glad you introduced yourself, finally! I wish you had spoke up sooner, but am glad you were able to find help and advice along the way. Rob has been a great help to many members here and we all hold great hope for his future and yours! The protocol you're finishing is an excellent one and with your RVR, the chance for SVR is highly likely. Your future is very promising indeed! I know your time left in Tx is short, but I hope you stay around and let us share in your successes. Let us know a little bit about yourself when you get a chance and good luck!

Tig



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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mac


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This is my first time to post and I wanted to thank everyone for the great information and encouragement I have received from this site. I have been reading along since my first TX and my last S/O dose is 09/16/2014. My SX were the worst, the first 4 days of TX. It was sooooo helpful to follow Fireman Rob, who was 2 weeks ahead of me, and many others. GT1A late 70's. Week #4 UND. I will now wait for 12 and 24 week tests. Truckin' much faster than before.....  Best of treatment to all.......!



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Gator Man


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Outstanding Sarabelle! I am coming up on 6 months post tx with an appointment on September 25th.  Once you clear EOT + 4 weeks still UND, the chance of relapse is very small. After that point, confidence builds that you will reach SVR and the months start flying by. The weight is definitely lifted and stress starts melting away. Good luck!



__________________

Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
pl1952


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Congrats Sarabelle -- you're heading in the right direction!



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Me: 62 yr. old female, GT 1b, fibroscan 4.5; VL 650,975 as of 2/4/14;started Harvoni 3/6/15; SVR


Hubby: 59 yrs.; GT1b; fibroscan 25-cirrhotic; S/O for 12 weeks started tx 3/20/14; SVR56; fibroscan done 7-7-15 = 8.5
Groupergetter


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Sarabelle wrote:

6 wks off tx and still UND! Whoooohoooooooooooo! I still can't believe it! Doctor wants to test three months post tx and final test at 6 months post tx.  6 months seems a long time for the final test... But oh well. I am still UND now while off the meds. I am so grateful and blessed right now I want to jump for joy and thank my lucky little stars ;) I spent so many years of my life worrying and stressing about the future and my health. Today I feel like a weight was lifted. Yes, I know it's not SVR time yet....but it feels pretty dang close :)

Congratulations biggrinbiggrinbiggrinbiggrin  YEEEEEEEEEEE HAAAW, sounds like you're almost home free.  What a blessing.  Happy for you.  



__________________

1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
Dee Dee


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Congrats Sarabelle! I am sure you will continue To be SVR. Great news!

__________________
G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
Sarabelle


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6 wks off tx and still UND! Whoooohoooooooooooo! I still can't believe it! Doctor wants to test three months post tx and final test at 6 months post tx.  6 months seems a long time for the final test... But oh well. I am still UND now while off the meds. I am so grateful and blessed right now I want to jump for joy and thank my lucky little stars ;) I spent so many years of my life worrying and stressing about the future and my health. Today I feel like a weight was lifted. Yes, I know it's not SVR time yet....but it feels pretty dang close :)



__________________

GT - 1a, VL 3,900,000. 30 years old AST 28. , ALT 36 had this for approx 10  - 12 years so far. Time to kick it! started olysio/sovaldi off label 5/6/14. 4 wk labs ast 16 alt 14 . hCV Undetected!! eOT 7/29/14. Labs UND ALT 11 AST 14
skewedButNotBroken


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Finbar, If I were you, I would drive by a fire station that has EMS capabilities (most do) and tell them you are experiencing heart palpitations. This way, you will not encounter any fees associated with the test that they will administer with the portable EKG machine that they all carry. If it comes back normal at least that will help calm your nerves, but I would still seek out my doctor as Isiscat suggested. 



-- Edited by skewedButNotBroken on Thursday 11th of September 2014 09:04:09 PM

__________________

Diag. with hep c in 1992; A3:F2;  GT 1a; IL28B CT; VL 900k, ALT 150, AST 100 on 8/5/2014; SOT 9/5/2014  S/O ---VL 127 after 6 days; VL detected on day 18 but < 15.; --> UND @ EOT+ 1 year SVR!
Gator Man


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Isiscat2011 wrote:
Finbar wrote:

Hi can you tell me if you get really sweaty at night with heart palpitations , I was fine a few weeks ago  then things went south now I have insomnia and body aches and I'm up all night with the chills Thanks

Hi Finbar:

You should contact your doctor.  A message board is not intended to be a substitute for professional medical advice or care.  Comparing side effects has limited value because we are all different.  Any drug can cause serious side effects and you should always err on the side of caution when using experimental drugs. The Sovaldi/Olysio combo is off-label because it has not been sufficiently tested to gain FDA approval for use together.  Hopefully these are transient and non serious side effects but I would check in with my doctor. Best regards. 

Isiscat is correct about contacting your doctor. Since you are a liver transplant recipient, your issues may be different regarding how you are monitored during tx and what sx are significant compared to the transplant naive members on this forum who have taken S/O.  Your sx, assuming they are from tx, seem a little more significant than most, although I wouldn't draw any conclusions from that observation.



__________________

Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Isiscat2011


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Finbar wrote:

Hi can you tell me if you get really sweaty at night with heart palpitations , I was fine a few weeks ago  then things went south now I have insomnia and body aches and I'm up all night with the chills Thanks

Hi Finbar:

You should contact your doctor.  A message board is not intended to be a substitute for professional medical advice or care.  Comparing side effects has limited value because we are all different.  Any drug can cause serious side effects and you should always err on the side of caution when using experimental drugs. The Sovaldi/Olysio combo is off-label because it has not been sufficiently tested to gain FDA approval for use together.  Hopefully these are transient and non serious side effects but I would check in with my doctor. Best regards. 

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Finbar


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Hi can you tell me if you get really sweaty at night with heart palpitations , I was fine a few weeks ago  then things went south now I have insomnia and body aches and I'm up all night with the chills Thanks



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Barry C
BigPharma


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no one is updating this topic ...

 


-- Edited by BigPharma on Thursday 11th of September 2014 08:46:46 PM

__________________

Treatment experienced, Hepc about 15 years , 41YO

2014 , 26JUL started treatment with daclatasvir and sofosbuvir (China ) 19DEC2014 -EOT

ALT/AST at start 60/50, now -19/19, VL at start 2,300,000 IU, UND @ weeks 4,8,12,17; SVR24 (11JUNE2015)

 

 

 
Tig


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Congratulations TC! Good luck with your upcoming HCV free life! Now it's time to relax and enjoy your job well done biggrin

Tig



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Gator Man


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tgcd78 wrote:

Just took my final S/O dose.  What an easy 12 weeks it has been but I am happy to be done.  Hopeful to resume a normal Hep C free life!

The Sx have been fairly light for most of us on the S/O regimen, particularly without Riba. As fortunate as we have been with our Tx protocol, let's hope that the new DAAs to be approved this year and next will also be easy to tolerate and even more effective.

Onward to SVR and a Hep C free life!smile Best of luck to you!



__________________

Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
tgcd78


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Just took my final S/O dose.  What an easy 12 weeks it has been but I am happy to be done.  Hopeful to resume a normal Hep C free life!



__________________

Female 35, Genotype 1a - Completed the OPTIMIST clinical trial - sovalid (400mg)/Olysio (150mg) |  Starting VL 8mil, 3 day VL 300, 1 week viral load UND

SVR - November 14th. 2014!!!
Pep


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Thanks Gator. It is great!



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58 y/o female. DX 9/12, Geno 1, Began S/O treatment 7/8/14. No prior treatments. 
Gator Man


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Outstanding Pep! A great day for forum members slaying the dragon!



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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Pep


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Great day for both of us. I got the same call today after 4 weeks S/O.  



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58 y/o female. DX 9/12, Geno 1, Began S/O treatment 7/8/14. No prior treatments. 
Pep


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Just got my call from the clinic. Undetected hep c after 4 weeks of S/O.  No side effects other than low tolerance to heat and infrequent headaches. Feeling blessed!

 



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58 y/o female. DX 9/12, Geno 1, Began S/O treatment 7/8/14. No prior treatments. 
pierre


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BraVO, TOM!



__________________

HCV 1b -- detected 2011 -- pre-cirrhotic -- vl has varied from 3million to 150thou-- first tx Sovaldi/Olysio started 2.6.14. finished 4.28.14. Since 4 weeks post-tx I have been UND with liver functions back to normal. SVR at 12 weeks post-tx.
Gator Man


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Great news Tom!!!



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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
pl1952


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Good going Tom!!!



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Me: 62 yr. old female, GT 1b, fibroscan 4.5; VL 650,975 as of 2/4/14;started Harvoni 3/6/15; SVR


Hubby: 59 yrs.; GT1b; fibroscan 25-cirrhotic; S/O for 12 weeks started tx 3/20/14; SVR56; fibroscan done 7-7-15 = 8.5
TomF


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The doctors office just called.  My 4 week (from start of treatment) results came back undetected!   smile



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Tom

HCV GT1a since 1983.  1998 - Interferon/ribavirin null responder.  7 Jul 2014 - started 12 weeks Solvaldi/Oysio, VL 5.5 million.  UND at SOT+4, EOT+4, and EOT+12 weeks.

falcon


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Quick follow-up: the outside lab results came back, and I'm now showing up UND. This was done using the COBAS TaqMan 2.0 test (which has an LLoQ of 15). The previous test was the Abbott RealTime HCV (which has an LLoQ of 12). While both tests advertise the same numbers for LLoD, if you read some of the documentation and studies, they actually detect the virus most of time at levels as low as 2.5-5 IU/mL, even if they're not able to quantify it at those levels.

Here are my updated results: 

Pre-treatment: 4.3 million
SOT + 3.5 wks: 89
SOT + 5.5 wks: 18
SOT + 8 wks: <12 DETECTED (Abbott RealTime)
SOT + 9 wks: <15 NOT DETECTED (TaqMan 2.0)

Based on these results, my doctor decided we'd stick with 12 weeks.

 



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Isiscat2011


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Fireman Rob wrote:

I chose to stick with my doc's VL test plan of SOT, EOT, 12 weeks EOT, and 24 Weeks EOT. The tests after EOT are going to be very stressful but I can't worry about that. 

After starting tx, I haven't worried about being UND because it doesn't seem to really play into SVR rates at all.  There are people who have relapsed and were UND at 4 weeks. Hopefully we all achieve SVR sooner than later and those waiting for S/L get it quickly.

This does make sense from a clinical standpoint because as you say becoming UND early doesn't appear to correlate to SVR.   With Sovaldi UND is almost guaranteed; the real question is how long UND will last once tx ends.  

Frequent testing can cause unnecessary stress too.  People can become too hung up on the VL reading and drive themselves crazy trying to predict the outcome.  That's probably what I will do--drive myself crazy.  Won't be the first time.  lol

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
falcon


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pierre wrote:

-- Falcon: I'd do my darnsdest to get the tx extended to 16 weeks. Good luck.

Just to follow up: we decided to test again at an outside lab to confirm the detected result. So this will be at almost 9 weeks. I'm hoping all it needed was that extra week to get to UND. But if not, trying to get insurance to cover an additional four weeks definitely seems like the best option.



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TomF


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Turns out I am getting a test at SOT+4 1/2 weeks.  I got a call to go back in - the vial was not properly frozen.  Again...



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Tom

HCV GT1a since 1983.  1998 - Interferon/ribavirin null responder.  7 Jul 2014 - started 12 weeks Solvaldi/Oysio, VL 5.5 million.  UND at SOT+4, EOT+4, and EOT+12 weeks.

Fireman Rob


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I chose to stick with my doc's VL test plan of SOT, EOT, 12 weeks EOT, and 24 Weeks EOT. The tests after EOT are going to be very stressful but I can't worry about that. 

After starting tx, I haven't worried about being UND because it doesn't seem to really play into SVR rates at all.  There are people who have relapsed and were UND at 4 weeks. Hopefully we all achieve SVR sooner than later and those waiting for S/L get it quickly.



__________________

Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!
Isiscat2011


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pierre wrote:

Happy update: Results of 12 weeks post TX blood work are in: virus undetected, so UND can be changed to SVR. Hurrah! S/O can & does slay the dragon. What a relief. Slept well, woke up at six & just lay there thinking through the last 3 years & that silly old line came into my head: This is the first day of the rest of your life. So it is. Emailed my son, told him to drink a glass of champagne to my health, as I no longer do that... Will in fact keep to the same healthy low-glycemic diet  plus exercise schedule that helped me prepare & wait for S/O. My thanks to all of you on this list too: it has been a great help to check in & get encouragements  & advice over these months. 

 

Pierre (ready to go on a solid hike today!)

Wonderful news, Pierre!  You did it.     By all means enjoy your hike.  This will be a hike and a day to remember.  The day you knew you kicked the dragon's ass.  Well done.



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Isiscat2011


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I would want to test at EOT + 4. If you are UND during tx an EOT seems superfluous.  

Looks like he wants 4 VL checks total.  

How about this: SOT, SOT+6, EOT+4, EOT+12.   My thinking is that you are even more likely to be clear at 6 weeks than 4 which would render the 8 week unnecessary.  Then you can save your final two for EOT 4 and 12. 

Actually, 8 weeks in is probably best if you are limited to a certain number, but few people are willing to wait that long. 

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
TomF


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I am 4 weeks into the S/O treatment.  Waiting for the test results now...

I had a discussion with the doctor about when to check V/L.  He wanted SOT, SOT+4, EOT, EOT+12. 

We agreed to test at SOT+8, but only if SOT+4 is not undetected.

I also told him I didn't see any point to checking at EOT.  We should move that to EOT+4.  Sound right?



__________________

Tom

HCV GT1a since 1983.  1998 - Interferon/ribavirin null responder.  7 Jul 2014 - started 12 weeks Solvaldi/Oysio, VL 5.5 million.  UND at SOT+4, EOT+4, and EOT+12 weeks.

Matt Chris


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Hey Pierre

"All Right" , Super congrats to your 12 weeks EOT UND SVR

The news just seems to get better

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
TomF


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Congrats Pierre!

 

 



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Tom

HCV GT1a since 1983.  1998 - Interferon/ribavirin null responder.  7 Jul 2014 - started 12 weeks Solvaldi/Oysio, VL 5.5 million.  UND at SOT+4, EOT+4, and EOT+12 weeks.

Caryn


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Pierre, fantastic!! I am so happy to hear the success stories!!! 

Sarabelle, congrats on completing treatment!!! Keep us posted!



__________________

1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
Fireman Rob


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Pierre,

That's awesome! I'm so happy for you and it's great to see this combo does slay the dragon. Thanks so much for posting your outstanding news!



__________________

Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!
Gator Man


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Outstanding Pierre on reaching SVR!  It does give new meaning to "the first day of the rest of your life". I hope your son enjoys the glass of  champagne to celebrate your good health! Stay in touch.

 

Sarabelle, congratulations on being UND at EOT! Pierre's son will be called on to have a second glass of champagne for your health in the near future!



__________________

Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
pierre


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Happy update: Results of 12 weeks post TX blood work are in: virus undetected, so UND can be changed to SVR. Hurrah! S/O can & does slay the dragon. What a relief. Slept well, woke up at six & just lay there thinking through the last 3 years & that silly old line came into my head: This is the first day of the rest of your life. So it is. Emailed my son, told him to drink a glass of champagne to my health, as I no longer do that... Will in fact keep to the same healthy low-glycemic diet  plus exercise schedule that helped me prepare & wait for S/O. My thanks to all of you on this list too: it has been a great help to check in & get encouragements  & advice over these months. 

 

Pierre (ready to go on a solid hike today!)



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HCV 1b -- detected 2011 -- pre-cirrhotic -- vl has varied from 3million to 150thou-- first tx Sovaldi/Olysio started 2.6.14. finished 4.28.14. Since 4 weeks post-tx I have been UND with liver functions back to normal. SVR at 12 weeks post-tx.
Sarabelle


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Just a quick update to all....EOT was 7/29/14 and UND.  I will be tested in 4 and than 12 weeks for SVR. Side effects during tx were brain fog, fatigue, anxiousness and headaches. Switched to taking the meds at night time after day 1 and all side effects disappeared....so really can't be sure if they can be called side effects, as they only showed up the first day I took the meds...maybe All in my head :)   I will keep you all posted. Cheers!



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GT - 1a, VL 3,900,000. 30 years old AST 28. , ALT 36 had this for approx 10  - 12 years so far. Time to kick it! started olysio/sovaldi off label 5/6/14. 4 wk labs ast 16 alt 14 . hCV Undetected!! eOT 7/29/14. Labs UND ALT 11 AST 14
pierre


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-- Falcon: I'd do my darnsdest to get the tx extended to 16 weeks. Good luck.

 

-- Thought the following article on the price and availability of S/O could be of interest to the group:

http://america.aljazeera.com/opinions/2014/8/patent-hepatitiscsovaldigileadsciencesmedicaid.html

 

p.s. 3 days to go until 12-week-post-tx results should be in. ever so slightly nervous despite excellent results so far. will keep ya'll posted.

 

Pierre



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HCV 1b -- detected 2011 -- pre-cirrhotic -- vl has varied from 3million to 150thou-- first tx Sovaldi/Olysio started 2.6.14. finished 4.28.14. Since 4 weeks post-tx I have been UND with liver functions back to normal. SVR at 12 weeks post-tx.
falcon


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36 yrs old, F3, treatment naive.

 

My doctor supports extending, but it may be difficult to get my insurance to cover it. It took 3 months of appeals to get this combination approved in the first place.



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jimbob


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Iiscat2011 wrote:

A kangaroo, a panda, and now a koala bear.  Too cute!!  Your grandson really seems to love the animals, Malcolm.   He looks very comfortable with them.

 I'm starting to think Malcolm is a zookeeper, ...a really smart zookeeper tho....



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jimbob: 64 y/o, GT 1A, F1-F2, diagnosed 1996. Since 1970. SOT 3.5 mil VL on 3/10/14 with Sov/Rib/Peg for 12 weeks. Tx naive. UND @ week 4,8,12. EOT 6/2/14.
Fireman Rob


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Falcon,

It would definitely help to know if you're Cirrhotic and if you're treatment experienced or not? There are people who have relapsed after being UND at 4 weeks on this combo but if you can extend, I would extend in a heart beat just to be sure. Riba doesn't seem to make much difference according to the limited data we have.

Your chances of SVR are great either way, especially as a 1b. That said, if my insurance would cover another month, I would jump on it, no question! Good luck.

-Rob



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Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!
Isiscat2011


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A kangaroo, a panda, and now a koala bear.  Too cute!!  Your grandson really seems to love the animals, Malcolm.   He looks very comfortable with them.



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
mallani


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Hi Falcon,

Welcome to the Forum. It would be useful to know your age, liver status and whether you are Rx-naive. The Cohort 1 Cosmos results were only for 14 patients, with one relapse. As you say, these are very small samples.

I wish they would come up with a RVR definition for Sovaldi. Every other HepC treatment has had one.

I'd definitely want to extend treatment to at least 16 weeks. All the best.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Isiscat2011


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Hi Falcon:

Extend.   What is your prior tx history?  Do you have cirrhosis?   



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
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