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Hep C Discussion Forum -> Hep C News -> Abbvie Findings: 2014 Conference on Retroviruses and Opportunistic Infections
Post Info TOPIC: Abbvie Findings: 2014 Conference on Retroviruses and Opportunistic Infections
Matt Chris


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Abbvie Findings: 2014 Conference on Retroviruses and Opportunistic Infections
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Hey Tig

Interesting reading, Abbvie certainly has one of the highest SVR rates for GT-1b to come from trials, to bad they have to wait another 8 months to get approved.

Here is a more detailed look at the study-http://www.natap.org/2014/CROI/croi_01.htm

Ribavirin on Abbvies GT-1b study did not seems to make much difference but their were no cirrhotics enrolled in the study, so longer duration and Ribavirin for cirrhotics is a safe and better approach.

Have been waiting 9 months for Abbvie's Turquoise II detail study results so I can figure out what went wrong with my treatment, I'm still in the dark and need to know which Rav's appeared and their current status to be able to choose the correct DAA's for treatment. Maybe in April at the EASL in England they will disclose, one can only hope.

matt 



-- Edited by Matt Chris on Saturday 8th of March 2014 06:11:28 AM

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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
mallani


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Hi Tig,

Thanks for the update. If I was Geno 1a, I'd still want ribavirin, and if cirrhotic, I'd want 24 weeks of the stuff.

Abbvie are hoping for the best, considering they are trialling newer (? better) versions of their drugs. Perhaps they will make it cheap! Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Tig


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Ribavirin unnecessary addition to 3-drug combination for HCV treatment

http://www.healio.com/infectious-disease/croi-2014-resource-center/ribavirin-unnecessary-addition-to-3-drug-combination-for-hcv-treatment

 

Investigational HCV combination treatment yielded high SVR rate

http://www.healio.com/infectious-disease/hepatitis-resource-center-2013/investigational-hcv-combination-treatment-yielded-high-svr-rate



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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