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Hep C Discussion Forum -> On Treatment -> Q80K NS3 polymorphism
Post Info TOPIC: Q80K NS3 polymorphism
Caryn


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Q80K NS3 polymorphism
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Malcolm, I thought I read this somewhere so I am glad that you re confirmed. 



-- Edited by Caryn on Wednesday 26th of March 2014 12:38:43 PM

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1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
Dee Dee


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My heart is swelling with happiness...thank you all. This forum and the wonderful people that participate in it have helped me feel so much better. I thank you from the bottom of my heart. ..feeling hopeful again. â¡

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G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
Fireman Rob


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Malcom,

I was hoping you would reply to this. This is great news- You're the man! 



-- Edited by Fireman Rob on Tuesday 25th of March 2014 09:33:22 PM

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Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!
mallani


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Hi Nadine,

If you were just using Olysio, the Q80K polymorphism is important, as this reduces the chance of Rx success. As you are using Sovaldi as the principal DAA, this should not be a problem, as Sovaldi is effective against this RAV. I would carry on. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Dee Dee


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My Doc just told me (via voicemail, missed his call) that  I do have the NS3 Q80K and that I shouldn't worry because he was going to have me do my treatment just as planned. He said it just meant that if I were to stop doing my treatment the virus could become more resistant. From what I read having this lowers my chances of this treatment working for me. I'm so bummed out I could cry. Anyone here have the same thing and still had luck with their treatment? cry



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G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
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