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Hep C Discussion Forum -> On Treatment -> Anyone know why?
Post Info TOPIC: Anyone know why?
mallani


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RE: Anyone know why?
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Hi John,

Don't worry about the enzymes. I was Undetected from week 8 to 48 and my enzymes stayed about the same as yours.

Even though there may be no liver inflammation, the constant remodelling causes enzyme elevation by itself. My enzymes eventually fell just into the normal range at EOT + 24w. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
JLynch30


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alt 79

ast 60

 


-- Edited by JLynch30 on Monday 5th of May 2014 11:31:02 PM

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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
Cinnamon Girl


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Hi John, I wouldn`t worry too much about your liver enzymes while you`re still on treatment.  It`s not unusual for them to fluctuate and I expect you`ll see them drop as you go further along.  Do you know what your latest alt and ast levels were?

Hope all`s going well for you!  smile



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Tig


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Hi John,

Just because you're undetectable doesn't mean your enzymes will immediately drop into normal ranges too. They somemtimes do, but just as often, they don't. The normalization of your liver enzymes comes in time for many people. Once the inflammatory process and the cause of it (HCV) have been corrected, the liver enzymes will start their correction as well. It takes some people time for those numbers to turn around, there is no set schedule to expect them to follow. You should begin to see things moving in that direction soon enough. 

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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JLynch30


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I am undetected but my alt/ast are still elevated? 



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
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