Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Hep C Discussion Forum -> General Discussion -> Open Source and how it effects Hep-c
Post Info TOPIC: Open Source and how it effects Hep-c
Huey


Guru

Status: Offline
Posts: 678
Date:
RE: Open Source and how it effects Hep-c
Permalink  
 

Full-size image (69 K)
Fig. 4. 

Comparison of the envelope proteins and their structural organization in TBEV and HCV. (A) Genomes of TBEV and HCV, with homologous coding domains in the envelope proteins indicated by dotted lines (Yagnik et al., 2000). (B) Structural components of the virus' outer shells: TBEV E-protein dimer and HCV E1E2 tetramer. (C) Construction of the HCV outer shell from the E1E2 tetramer. For clarity, only a facet of the icosahedral shell is shown, and the 3- and 5-fold symmetry axes are indicated.

Figure options


__________________

  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
hrsetrdr


Guru

Status: Offline
Posts: 940
Date:
Permalink  
 

Huey,

Thanks for bringing up the topic- yes, with the advent of super computing and the use of Open Source(non-proprietary) software it has been possible to conduct computer modeling in pursuing "the cure" in all sorts of medical research.

For 10 years I've participated in, and donated computing time for a project at Stanford University called Folding@home.

    • Folding@home
      Project
    • Folding@home is a distributed computing project for disease research that simulates protein folding, computational drug design, and other types of molecular dynamics. Wikipedia
    • Related topics
      . . . Stanford University's Folding@home distributed computingprotein research project keeps track of how much computer power is donated by users, and currently 6 of the top 100 teams are organized by Apple community-related websites. Wikipedia
      Its [Folding@home] primary purpose is to determine the mechanisms ofprotein folding, which is the process by which proteins reach their final three-dimensional structure, and to examine the causes of protein misfolding. Wikipedia
      Explore: Protein folding
      Vijay S. Pande is the Director of the Biophysics Program and is best known for orchestrating the disease research project called Folding@home distributed computing. Wikipedia
  2.  


__________________

"hrsetrdr"=Tim

Treatment halted on Aug.8,2012 due to vision problem.  6 month post tx labs

Aug.2013 SVR

Be strong when you are weak, brave when you are scared, and humble when you are victorious.
- Unknown

 

 
Paul B


Senior Member

Status: Offline
Posts: 204
Date:
Permalink  
 

Huey wrote:

confuse  Science has not had this kind of upset since the Boson partial.  Advances in Hep-c treatment and HIV are due in part to the use of super computers like the famous KARKEN to model a single three dimensional virus core and mapping it.  With the HIV virus floating around in a modal on the screen we can see things that we never have seen before.  Scientist have now taken on the challenge of studying the behaviour of the virus at different stages in the replication process.  Now comes the hard part, when I say hard I mean near impossible.  What they found is that it unfolded it's self to form a kind of armour and if we could somehow cripple this process or prevent it all together.  But how does it unfold?  To figure this out science turns to Open Source.  A game was created. A puzzle game. And thousands upon thousands of participants played and Did find out just Exactly how the HIV  unfolds .  Next is the Hep-c virus and with the new DAA and no doubt the help of the internet community that extends around the globe.

 That is beyond cool.



__________________

57 Yr old, Diagnosed 1994 Geno 1a. 1995: Interferon 12 weeks.  1998: Int/Rib 10 weeks.  2014: VL 106,000. Peg Int, Ribavirin, Victrelis 48 weeks (commenced June 2014). UND after Peg/Int lead in week 4. Still UND at week 8, 24, EOT. SVR 12.

TazKat


Senior Member

Status: Offline
Posts: 479
Date:
Permalink  
 

wow!!!!! blankstare 

3 shots left!!  I am not losing my mind this week.. lol  biggrin



__________________

TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
Huey


Guru

Status: Offline
Posts: 678
Date:
Permalink  
 

Can Open Source co-operation re-invent Sovaldi and patent then release it to the public making it almost free?

__________________

  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Huey


Guru

Status: Offline
Posts: 678
Date:
Permalink  
 

confuse  Science has not had this kind of upset since the Boson partial.  Advances in Hep-c treatment and HIV are due in part to the use of super computers like the famous KARKEN to model a single three dimensional virus core and mapping it.  With the HIV virus floating around in a modal on the screen we can see things that we never have seen before.  Scientist have now taken on the challenge of studying the behaviour of the virus at different stages in the replication process.  Now comes the hard part, when I say hard I mean near impossible.  What they found is that it unfolded it's self to form a kind of armour and if we could somehow cripple this process or prevent it all together.  But how does it unfold?  To figure this out science turns to Open Source.  A game was created. A puzzle game. And thousands upon thousands of participants played and Did find out just Exactly how the HIV  unfolds .  Next is the Hep-c virus and with the new DAA and no doubt the help of the internet community that extends around the globe.



__________________

  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.
Hep C Discussion Forum -> General Discussion -> Open Source and how it effects Hep-c
Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.