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Hep C Discussion Forum -> On Treatment -> what dose this mean?
Post Info TOPIC: what dose this mean?
mallani


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RE: what dose this mean?
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Hi Omar,

The aim of treatment is to clear virus down to Undetectable levels in the plasma. In a patient with little liver damage, the virus should be cleared from the liver cells. It may persist in blood monocytes and some other tissues, but after SVR, the body can cope with this tiny amount of residual virus via the immune system. Relapse after SVR is given as <1% and this decreases over time, but you are never 'cured' in the true sense of the word. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
beingsassy


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I started tx with a vl of 19 million. Still UND after 4 weeks post tx. Will have more labs done in late nov. A high viral load is a negative predictor on the tx I was on but that is just one. I had about 3 negative predictors but they say 4 is the cutoff for a good expected result. So I'm hopeful. A high vl does not mean u won't be cured. I think we just need to keep hope alive even if we don't get the cure on the first try. I know if I relapse, I'll try again. Probably not right away but after a while i will. I think positive thinking is important on any tx which is why we are all here. To have a place to vent, support and knowledge.

gigi



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genotype 2 completed sovaldi and ribavirin on 6/4/14. SVR on 12/3/14
Omar


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mallani wrote:

Hi Bama,

It means you have 2.6 million viruses per ml of blood. That's 2.6 billion per litre. Average blood volume is 5 litres, so that's 13 billion viruses in the blood. It's estimated that blood contains about half the virus, so total viral particles in the body is 26 billion. As so many viral replications don't survive, this is why the total replications per day is about 1 trillion. Best not to think about it !

Depending on who you listen to, that's a medium- high VL. Cheers.

 Hi Mallani

Does the tx remove the virus from the body or only from the blood?

If not removed from the body, can it again become active if the immune system weakens?

Thanks

 



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Male 31 Years Old

Diagnosed with HCV GT-3a in June 2014

Sovaldi+Riba for 24 weeks started on 8 August 2015

 
TazKat


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lol  huey!!!   mine was 1,250,000 when I started treatment. 



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
Huey


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mallani wrote:

Hi Bama,

It means you have 2.6 million viruses per ml of blood. That's 2.6 billion per litre. Average blood volume is 5 litres, so that's 13 billion viruses in the blood. It's estimated that blood contains about half the virus, so total viral particles in the body is 26 billion. As so many viral replications don't survive, this is why the total replications per day is about 1 trillion. Best not to think about it !

Depending on who you listen to, that's a medium- high VL. Cheers.

 This reminds me of a bounced check.

 



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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
hepcinbama


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holy smoke ! throw some hep c on the Barbie! are you kidding me I thought 2 million was a lot you officially blew my mind ! that was mind boggling! thank you for the info an I do want to say I had the extreme pleasure of spending 7 days in your country in 1982 in the beautiful town of Perth an got the pleasure of diving Rottnest island the cleanest country I ever visited an the most hospitable people I ever met they came to our ship an picked us up took us to their homes feed us an took us out on the town an would not let us spend a dime .I felt very welcome there ! an the beer was a wicked strong !



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hep c geno 3     2,600,000 viral load   started 12 week tx of peg pen rib an solvaldi the wonder drug! first time being treated after living in Egypt for 6 years on a river called De-Nile!
mallani


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Hi Bama,

It means you have 2.6 million viruses per ml of blood. That's 2.6 billion per litre. Average blood volume is 5 litres, so that's 13 billion viruses in the blood. It's estimated that blood contains about half the virus, so total viral particles in the body is 26 billion. As so many viral replications don't survive, this is why the total replications per day is about 1 trillion. Best not to think about it !

Depending on who you listen to, that's a medium- high VL. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
hepcinbama


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thank you



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hep c geno 3     2,600,000 viral load   started 12 week tx of peg pen rib an solvaldi the wonder drug! first time being treated after living in Egypt for 6 years on a river called De-Nile!
Gracie


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Medium ... I've seen them as high as 25,000,000. Viral load changes daily though, so not a predictor of liver damage. Just a baseline to measure treatment success.



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  1. Gracie

1A. Previously treated non responder Rebetron in 2000 And Incevik in 2014 with a breakthrough at week 12. Fibroscan 15.5. VL 6,000,000. Finished 24 weeks harvoni on Dec. 19, 2015. SVR. Latest Fibroscan 8.8.
hepcinbama


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 hep c quantitation 2600000 copies ml        this is what my paperwork said! is this high, low, med  average? an what dose it mean there are 2million 600 thousand hep c viruses in me ?



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hep c geno 3     2,600,000 viral load   started 12 week tx of peg pen rib an solvaldi the wonder drug! first time being treated after living in Egypt for 6 years on a river called De-Nile!
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