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Post Info TOPIC: New Articles on Great informational website


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RE: New Articles on Great informational website
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Hi

 This is the reading of a paper on the New Meds from the same site.

 Video:
CLD 369 Reading
http://link.brightcove.com/services/player/bcpid3539748004001?bckey=AQ~~,AAAAmNAjFMk~,4a85zAmZPcRCbGtQDRUKAyG_lkG9JU0P&bclid=0&bctid=3637035449001

Suzi



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Geno 1A  Age 82 Treatment naive Cirrhotic Told I had liver disease in 1966. Diagnosed as Hep C 1999.Started Merck clinical trial with Riba on 9/9/2013 Week 1 and 2 <25  Weeks 4, 8, 12,16,18 UND.  EOT Jan 14,2014  EOT +12 UND   JULY 1 2014 EOT+24= SVR



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Nevermind, I was able to get into them; thanks.



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Me: 62 yr. old female, GT 1b, fibroscan 4.5; VL 650,975 as of 2/4/14;started Harvoni 3/6/15; SVR


Hubby: 59 yrs.; GT1b; fibroscan 25-cirrhotic; S/O for 12 weeks started tx 3/20/14; SVR56; fibroscan done 7-7-15 = 8.5



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Interesting Article Susan,

I did notice the HCV therapy analyzed was INF based treatments. Can't help it but wonder if the end results would be different on the DAA based treatments? Maybe not?

Thanks for the good read Suzi.

-Rob



-- Edited by Fireman Rob on Saturday 12th of July 2014 05:58:46 PM



-- Edited by Fireman Rob on Saturday 12th of July 2014 05:59:25 PM

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Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!



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Hi guys, I'm unable to access the articles on either links provided.  Is there another way?  Thanks!



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Me: 62 yr. old female, GT 1b, fibroscan 4.5; VL 650,975 as of 2/4/14;started Harvoni 3/6/15; SVR


Hubby: 59 yrs.; GT1b; fibroscan 25-cirrhotic; S/O for 12 weeks started tx 3/20/14; SVR56; fibroscan done 7-7-15 = 8.5



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mallani wrote:

That's a coral trout, one of our best reef fishes. We went out on a charter last weekend and filled our freezers.


 We used to go out on the Ranger85 at Cisco's Landing and fish for rock cod mostly, and various species of flatfish as well.   The coral trout you're holding reminds me of the cow cod that most anglers delighted in hooking.



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"hrsetrdr"=Tim

Treatment halted on Aug.8,2012 due to vision problem.  6 month post tx labs

Aug.2013 SVR

Be strong when you are weak, brave when you are scared, and humble when you are victorious.
- Unknown

 

 



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How incredibly disappointing. I just want to forget about this



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Genotype 1a

1/18/13 -  VL 1.5mil triple therapy with boceprevir

2/3/14 - relapsed. 1.7ml

 

6/28/14 - started solvadi interferon and ribavirin for 12 weeks

7/28/14 - week 4 undetected dosage reduction of rib and peg

 

11/2/14 und 4 weeks post eot

 

g

 



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I was curious about this very subject and looked up an article the other day by a doctor that said HCV couldn't be transmitted after SVR. Before I read the article I assumed it could be, then was thrilled to read it couldn't . Now I'm reading it can be. Crap!



-- Edited by jimbob on Saturday 12th of July 2014 09:18:29 PM

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jimbob: 64 y/o, GT 1A, F1-F2, diagnosed 1996. Since 1970. SOT 3.5 mil VL on 3/10/14 with Sov/Rib/Peg for 12 weeks. Tx naive. UND @ week 4,8,12. EOT 6/2/14.



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Nice looking fish, I like the Tie-Dye shirt it's wearing. lol/ Sorry to hear about the nose.



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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 



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Suzi,

As far as I know, our virus can't replicate in cat or dog hepatocytes, ergo cats and dogs can't get HepC.

Tim,

That's a coral trout, one of our best reef fishes. We went out on a charter last weekend and filled our freezers.

Isiscat,

I've had so many solar keratoses and BCC's burnt of my nose, it will never see the sun again!



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Hi Suziq:  I'm sure Malcolm will have a good answer for you soon but in the meantime I can share what I learned about this.  I was concerned about giving the virus to Isis but found out that neither cats nor dogs can contract it.  They can get other forms of hepatitis but not the human kinds.  Primates are different because they are so genetically similar to us.  You can find more information here:  http://pets.thenest.com/can-cats-contract-hepatitis-c-humans-10837.html

Cats can also get a type of HIV but it is not the same as human HIV.  It is known as FIV.  I took in a stray cat about 20 years ago who had FIV; his name was Clyde. I treated Clyde with Interferon and he lived to be 14 years which was kind of a record back then for FIV positive cats.  I didn't know anything about Interferon at the time but I sought out a vet who specialized in treating FIV cats and he recommended it.  Interferon definitely extended Clyde's life but he often looked like he didn't feel well,  particularly in his last couple of years,  and I would not use Interferon on an animal again for an extended period of time.   



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.



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That's always been recognized. That's why we should continue to take precautions after SVR. The d get more research, we should assume we remain infectious for the rest of our lives. I know it's a sobering thought.

Hi Malcolm,

My cat accidently scratched me tonight and I bled rather profusely.  As I wiped the blood away, I noticed a little on his fur.  The article said that the experimentation about transmission was done on monkeys (That is upsetting).  Then I wondered if we could transmit Hep C to our dogs or cats.  Or if they can get it from us.  Can they get hepatitis ?  How would it manifest in them?  Is there any info on that?  Many of us have pets and until I read the article and then got scratched tonight, I had not even considered it.  Do you happen to have any info on that or know how or where I might find it?

SuziQ

 

 

 



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Geno 1A  Age 82 Treatment naive Cirrhotic Told I had liver disease in 1966. Diagnosed as Hep C 1999.Started Merck clinical trial with Riba on 9/9/2013 Week 1 and 2 <25  Weeks 4, 8, 12,16,18 UND.  EOT Jan 14,2014  EOT +12 UND   JULY 1 2014 EOT+24= SVR



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hrsetrdr wrote:

Malcolm, that's a handsome catch- 

__________________________________________________________________________________________________________

I agree; I like a man who has the sense to apply sunscreen to his nose.  Oh.......you meant the fish!!   My mistake.   LOL

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.



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Sobering, yes- that news puts things in perspective for sure. Also explains why the word "cured" is not in my gastro doc's vocabulary.

Malcolm, that's a handsome catch- cow cod?

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"hrsetrdr"=Tim

Treatment halted on Aug.8,2012 due to vision problem.  6 month post tx labs

Aug.2013 SVR

Be strong when you are weak, brave when you are scared, and humble when you are victorious.
- Unknown

 

 



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Hi Tim,

That's always been recognised. That's why we should continue to take precautions after SVR. The risk passing the infection is small, but our bodies have learned to cope with our tiny amount of residual virus. Until we get more research, we should assume we remain infectious for the rest of our lives. I know it's a sobering thought.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Suziq,

Thanks for the link to the articles, I am a bit unsettled after reading the article titled "Hepatitis C - Transmission of the virus following antiviral treatment"      It's late and I'm a bit tired, but the article refers a study that apparently demonstrates that former HCV patients can in essence be infectious with the trace amounts of the HCV RNA that they carry, despite having achieved SVR.   Full article



__________________

"hrsetrdr"=Tim

Treatment halted on Aug.8,2012 due to vision problem.  6 month post tx labs

Aug.2013 SVR

Be strong when you are weak, brave when you are scared, and humble when you are victorious.
- Unknown

 

 



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Hey Suziq

Great article, it give a real world hope for all HCV patients with fibrosis. Just understanding more about inflammation is worth the read. The next thing is to figure out what the factors are that can cause liver inflammation other than HCV. Maybe just figuring out something that we can eat or something we should not eat, or maybe its a emotional/stress factor is involved. With all the hormones, peptides, adrenaline, and and other chemistry that the body can produce in a moments notice that can create or reduce inflammation it makes me realize that we have a enormous amount yet to be figured out.       

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 



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Hi Susiq,

Good article. Hope you're well. CheersXX



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Try this--I just got the same forbidden that you did.  The articles are really great.  For instance, one is saying that HCV can still be transmitted to others even after SVR.  Hope this works.  If not, copy and paste into your search line.  The articles I was referring to were the third and sixth ones --- About transmission AFTER SVR and Histology after SVR.  They have lots of good articles on this site.

 

HCV New Drugs And Liver Health - FeedBurner

 



-- Edited by suziq on Friday 11th of July 2014 01:06:53 AM

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Geno 1A  Age 82 Treatment naive Cirrhotic Told I had liver disease in 1966. Diagnosed as Hep C 1999.Started Merck clinical trial with Riba on 9/9/2013 Week 1 and 2 <25  Weeks 4, 8, 12,16,18 UND.  EOT Jan 14,2014  EOT +12 UND   JULY 1 2014 EOT+24= SVR



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I wanted to read this but when I tried I got the message, I did not have permission.



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Tig


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Thanks for those articles Susan. I found the article on fibrosis regression particularly interesting. Seems that inflammation scores always had a significant impact on fibrosis. My inflammation scores were always low and according to this, may have been one reason I didn't advance to cirrhosis over the 30+ years I was actively infected. I recommend everyone reading this far to spend some additional time reading these articles. They offer explanations to many of the questions we all share here on the forum. Susan has a knack for finding good, relevant articles that deal with core issues of this disease and it appears that she has done it again! 

Tig



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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A couple of articles caught my eye today on this website.  It posts to my email daily.

Transmission of HCV after SVR

Regeneration of liver after SVR.

Guess they caught my eye as I just got my notification of SVR.  Although I am not happy with the use of animal testing for the first article, the information is valuable for those of us reaching (or hoping to reach) SVR. 

The second brings hope.

The articles are well worth reading.

HCV New Drug Research - blogspot.com

SuziQ

 

 



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Geno 1A  Age 82 Treatment naive Cirrhotic Told I had liver disease in 1966. Diagnosed as Hep C 1999.Started Merck clinical trial with Riba on 9/9/2013 Week 1 and 2 <25  Weeks 4, 8, 12,16,18 UND.  EOT Jan 14,2014  EOT +12 UND   JULY 1 2014 EOT+24= SVR

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