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Hep C Discussion Forum -> On Treatment -> What is the relapse rate with the Sovaldi / Ribaviron 24 week protocol?
Post Info TOPIC: What is the relapse rate with the Sovaldi / Ribaviron 24 week protocol?
thepoet


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RE: What is the relapse rate with the Sovaldi / Ribaviron 24 week protocol?
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Thank you for the data...and I like your cat too...LOL...LOL



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DJ...dx 2005...geno 4c...twice interferon/riba failure....completed 24 weeks Sovaldi & Riba on 10/18/14....SOT VL 600,000 after 16 days VL <43. Day 45 <43 again. Day 59...8 weeks UNDETECTED.

Happy and grateful to God for new life....
Isiscat2011


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Hi Poet:

I didn't mean to suggest you are a worrier.  Actually, I think of you as a warrior!  

I guess I'm the worrier because I'm worried that reading about relapses is psyching some people out when they are on tx.   Anyway, here is some clinical trial data on genotype 4s and the 24 weeks arm looks pretty impressive: 

 

May 12, 2014

Sovaldi and Ribavirin Effectively Treat Genotype 4 of Hep C

 

 

Twenty-four weeks of Gilead Sciences Sovaldi (sofosbuvir) and ribavirin boasted high cure rates among people with genotype 4 of hepatitis C virus (HCV) in a recent trial, aidsmap reports. Results from the Phase IIb open label trial of 60 Americans born in Egypt, a bit less than half of whom were treatment naive, were presented at the 49th annual meeting of the European Association for the Study of the Liver (EASL) in London.

Most of the treatment-naive participants were deemed interferon intolerant, while those who had previously failed therapy had either relapsed, not responded to therapy or stopped taking treatment because of side effects. Most of the participants had unfavorable IL28B non-CC gene variants, and almost 25 percent had compensated liver cirrhosis.

The study randomly assigned the participants to receive a daily dose of the polymerase inhibitor Sovaldi and ribavirin for either 12 or 24 weeks.

Sixty-eight percent of those who took 12 weeks of therapy achieved a sustained virologic response 12 weeks after completing therapy (SVR12, considered a cure), compared with 93 percent of those receiving 24 weeks of therapy. The treatment-naive participants had respective SVR12 rates of 70 percent and 100 percent in the 12- and 24-week arms. Those who had previously failed therapy had respective cure rates of 59 percent and 87 percent.

The regimen proved generally safe and well tolerated. The most common adverse side effects were headache, insomnia and fatigue.



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Huey


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I am on a 24 week treatment and I was one of the first to get  it,, And I am not done yet, It is just too early  to have any relapse information for the 24 week treatment folks.  The ones outside of the trials that is.



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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
thepoet


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Thanks Cat for your input. I wouldn't say that I'm worried, I am just curious to know the data, I have a curious/scientific mind. I am not generally a person that drives myself crazy with worry, unless I was really sick, so it wouldn't be counterproductive. I am generally a calm person. I never thought about relapse rate until I came to the forum and saw threads discussing the topic, which made me curious. I did my research regarding Sov/Riba as it relates to my genotype. I've always been a curious individual and I suppose I will continue to be. I'm sure that if I research the web, I will find some sort of stats.



__________________

DJ...dx 2005...geno 4c...twice interferon/riba failure....completed 24 weeks Sovaldi & Riba on 10/18/14....SOT VL 600,000 after 16 days VL <43. Day 45 <43 again. Day 59...8 weeks UNDETECTED.

Happy and grateful to God for new life....
Isiscat2011


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There are several threads devoted to the topic of relapse and if you do a search with the tx drugs you are on you will find them.  My opinion is that there is no point in worrying about relapse once we are on tx.  The time to study this is before tx in order to make the best tx decisions we can but even then nothing is written in stone.  During tx it isn't really constructive and could be very upsetting.     

Suffice it to know that the odds of SVR are in our favor with just about any tx that is being used today -- and the odds are only getting better.  All the knowledge and statistical data in the world can't change the individual outcomes, however.  Just my opinion.

I'm glad you are feeling MARVELOUS, Poet.  As the comedian Billy Crystal would say: that is MAWVELOUS DAHLING, ABSOLUTELY MAWVELOUS!  



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
thepoet


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I am truly grateful to be UNDETECTED going into week 11. Today is an amazing day. I'm experiencing no sides today...just feeling MARVELOUS! However, I am curious to know the relapse rate.



__________________

DJ...dx 2005...geno 4c...twice interferon/riba failure....completed 24 weeks Sovaldi & Riba on 10/18/14....SOT VL 600,000 after 16 days VL <43. Day 45 <43 again. Day 59...8 weeks UNDETECTED.

Happy and grateful to God for new life....
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