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Hep C Discussion Forum -> On Treatment -> A few Sovaldi+Olysio Tx-related questions
Post Info TOPIC: A few Sovaldi+Olysio Tx-related questions
Huey


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RE: A few Sovaldi+Olysio Tx-related questions
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Hi,,, Keeping something refrigerated means that the heat "Latin heat  or hidden heat" is removed from inside the cabinet and released outside by the condensing coil. Hot always go to cold.  The inside of the bottle has not only the meds but Air, the air contain moisture. This will become condensate inside the bottle and cause spoilage probably. Also a refrigerator has mold, fungi and other live things you don't won't in contact with this medication.  When they ship it it is vacuum sealed   No air or moisture inside so they can ship it in a cooler without concern of condensate forming on inside of bottle/.

 

 Stopping Tx before the 12 week's is Not a good idea.  Think of it as a mine field, If you don't walk right in the footprints of the guy before you my get taken out.  Booom.  Standing in the middle you look around and you see a lot of unknown,  Any spot could have a hidden mine,  Do you wont to venture out on your own, or do you walk right behind the person in front of you? 

  Try this,, Get some coconut oil,, put a tablespoon full in your mouth,swish it around Don't swallow it. just keep it in your mouth and swish it around, for three minutes.  Then spit it out.. This is called an oil pulling.  It won't replace brushing but will do a fine job of removing plaque for your teeth.

   Taking the med's on time is important.  The plasma has a half life of 26 hours and it takes 2 hours for it to get into your system.  If you should ever get sick "Through up" after taking the meds if it has been two hours or more it is already in your system and No need to re-dose.  Less than two hours and you need to take it again.  I take my Sovaldi in the PM because my tummy is already had food in it and is  less likely  to loose a $1000 pill  getting sick.

  If Anything like this happens during your treatment Tell your Doctor, It is important he or she knows these things. smile



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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Isiscat2011


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Mike716 wrote:

- What are the consecuences of stopping S+O Tx before 12 weeks? I've read that Olysio can cause not only a skin rash but gingivitis. This is particularly worrying to me as I have lost many teeth in the past due to gum infections. Another bout with gingivitis will not only leave me toothless but is very dangerous for me. If I do get gingivitis during treatment, maybe I should stop taking the meds. But what will be the results of stopping? 

         ___________________________________________________________________________________________________________

An obvious consequence is that your odds treatment failure increase substantially.  RAVs are also a possibility but there is no solid data about that yet. Costs and retreatment are additional considerations.  Discontinuation of the meds is a fairly extreme measure and should not be warranted due to gingivitis.  It takes time for gingivitis to become advanced periodontal disease, so that isn't going to happen in a few months, particularly if you take care of your dental health during tx.  

It is a really good idea to see a dentist before beginning tx but I am not aware of any reason a general dental cleaning could not be performed during tx.  Also, a dentist can prescribe special toothpaste and mouthwash that can help prevent gum disease and/or maintain good dental health.  Do you have access to a dentist with whom you can discuss your concerns, Mike?  Perhaps a good cleaning and some Rx strength toothpaste and mouthwash will resolve these issues and set your mind at ease.



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Tig


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Hi Mike,

Regarding the temperature, this is from Gilead's own recommendations:

 

"STORAGE AND STABILITY

Store at 15 to 30 °C (59 - 86 °F).

  •  Dispense only in original container

  •  Do not use if seal over bottle opening is broken or missing. "

While refrigerated storage may not be detrimental to it's effectiveness, I can't be the one to say it can't be. There must've been a reason they gave specific temperature ranges, so I'd defer to their knowledge and instructions on this one. 

As far as stopping the treatment ahead of schedule, I wouldn't recommend that. If you read the reports from the various study literature, they experienced SVR failures because of it. The belief is that exposure to the chemicals for a specific amount of time allows for complete and adequate tissue perfusion which provides the time necessary to break the replication cycle of the virus. This treatment requires the use of your own immune system to provide the sustained viral response. So if you cut the tissue exposure short, you're risking everything. There's a reason they perform these studies and that's to determine the required length of exposure to and strength of the medication used.

As far as your gingivitis, it's something you should be able to control with attention to personal dental care and if you're really concerned that you can't control it, set up more frequent dental screenings. I wouldn't think it should be a problem that would compromise your treatment outcome. Just being extra cautious should provide you with enough forewarning of potential problems.

I personally think you should take your meds on a set schedule everyday. It provides for a consistent blood level of the medications. My protocol was absolutely specific and required taking the medications at the same time, everyday, for 28 weeks. Again, it's a schedule established through the trials and provides for your best opportunity to achieve SVR. I wouldn't mess with success!

Good luck,  Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Mike716


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Hi, all.

Just a few questions about treatment with Sovaldi + Olysio that hopefully some knowledgable people here will be able to answer:

- Why shouldn't the meds be stored in a refrigerator? I was told this by the specialty pharmacies. I understand that there can be a lot of humidity in refrigerators, but wouldn't the meds be okay if the bottles are unopened? Keeping them lying around, in the New York summer, just doesn't seem like a good idea.

- What are the consecuences of stopping S+O Tx before 12 weeks? I've read that Olysio can cause not only a skin rash but gingivitis. This is particularly worrying to me as I have lost many teeth in the past due to gum infections. Another bout with gingivitis will not only leave me toothless but is very dangerous for me. If I do get gingivitis during treatment, maybe I should stop taking the meds. But what will be the results of stopping?

- Is it important to take the meds at exactly the same time every day, or does a couple of hours one way or another make no difference?

- Is it okay to take S+O at mid-day with lunch?

If this stuff has already been covered in the forum, I apologize. I don't have the time or energy to go back through all the posts on S+O. Plus I am receiving almost zero medical support (believe it or not).

Thanks in advance for your help.

Mike



__________________

70-year-old male. Diagnosed HCV+ in 2008 with geno 1b. 2008 biopsy: A2/F1. Now F2+, with platelets down. No insurance, so applied for Sovaldi and Olysio patient assistance. Trying to get into a trial for 5 years with no luck.
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