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Hep C Discussion Forum -> On Treatment -> Not much side effects. Is it bad?
Post Info TOPIC: Not much side effects. Is it bad?
Paul B


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RE: Not much side effects. Is it bad?
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Yes I see now after looking at the diagram.  Und @ wk 4 references the period after starting Victrelis.  Seems I have gone one better than that with Und after the lead in.  Anxoously awaiting the next VL test

 

Overall I am not feeling too bad. Live in constant fear of missing pills but I have smartphone alarms going off all day



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57 Yr old, Diagnosed 1994 Geno 1a. 1995: Interferon 12 weeks.  1998: Int/Rib 10 weeks.  2014: VL 106,000. Peg Int, Ribavirin, Victrelis 48 weeks (commenced June 2014). UND after Peg/Int lead in week 4. Still UND at week 8, 24, EOT. SVR 12.

mallani


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Hey Paul,

The RVR definition for Victrelis is Undet. after 4 weeks on Victrelis, and eRVR is 4 weeks later.

With your Undet. after the leadin, I'm not sure how this works out, but I'd press for a 9 week VL just to make sure.

With a Hb of 158, you should feel OK. Mine had dropped to 81 by week 8. Carry on buddy, and don't miss any pills!



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Paul B


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Hey Mal,

last Hb was 158, so went up a couple of points.  Week 8 becomes week 9 for me, so I guess next VL load check is 3 weeks from tomorrow. Neutophils was 1.1.



-- Edited by Paul B on Tuesday 29th of July 2014 10:44:22 AM

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57 Yr old, Diagnosed 1994 Geno 1a. 1995: Interferon 12 weeks.  1998: Int/Rib 10 weeks.  2014: VL 106,000. Peg Int, Ribavirin, Victrelis 48 weeks (commenced June 2014). UND after Peg/Int lead in week 4. Still UND at week 8, 24, EOT. SVR 12.

mallani


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Hi Paul,

How's your Hb holding up? The Riba rash is a bit of a pain. Don't scratch and some topical low-dose steroid ointment are useful

When's your next VL? Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Paul B


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I am in week 8 on triple, but with Victrelis.  I am pretty tired, rash on face feel a bit crap, and my body feels hot to touch.  Overall though, the side effects have been much less severe than anticipated.  Many days I have barely felt anything at all. I was undetectable at week 4.  Hope this time it is gone for good.



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57 Yr old, Diagnosed 1994 Geno 1a. 1995: Interferon 12 weeks.  1998: Int/Rib 10 weeks.  2014: VL 106,000. Peg Int, Ribavirin, Victrelis 48 weeks (commenced June 2014). UND after Peg/Int lead in week 4. Still UND at week 8, 24, EOT. SVR 12.

Scruffy


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Theres some of us here that were and are still on that treatment. I'm a 48 week-er. I was still undetectable at 7 weeks post treatment. We are here for you guys. Remember that it helps to know there are peeps that have been down the road your on to seek advise from. 

 



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Geno 1a null responder 2004 inter/riba   finished incivek,peg/riba 48 weeks May 17th 2014. undetect weeks 4-12-32.  EOT+7 undetect. EOT+24 SVR!!!!! EOT+!YEAR SVR!!!!
Midnight


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Hi

 

I'm on week 27 of the triple.

 

I found that by the time the Telap had built up enough in my system to begin to really upset me it was almost week 12.

 

What I found was the Telap made me very tired but not enough so I couldn't get around, a random itch appeared which was always worse before bedtime and if I didn't eat enough fat with it I had the most terrible ring sting!

 

For a few days after the Telap was over I had a terrible bout of itchyness which then went. A week or so later I felt much better and discovered a new found energy.

 

I wouldn't be worried about whether its working or not as although I had minimum sides I was UND at 4 weeks...

 

Best wishes



__________________

Genotype 1A, Fibroscan 14, enlarged spleen.
Failed 48Wk triple therapy (Telap) treatment Jan-Dec 2014. 12 Week Harvoni/Riba started 22/12/15...

Week 2; ALT 50 HCV 96
Week 4; ALT 41 HCV 20
Week 8; ALT 34 HCV UND

EOT +4 weeks; ALT 27 UND

SVR 12; ALT 25 UND

SVR 18mths; ALT 26 UND
Isiscat2011


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Hi buny:

When a bunch of us here were on the Incivek tx we used to speculate about what the severity of our initial side effects meant.  Some people had a theory that the worse the side effects the better your odds for SVR.  That is probably malarkey.  The only real indicator of how the virus is holding up under the attack of the drugs is the viral load test. The 4 week blood test is quite significant. It will tell you whether you have achieved RVR (rapid viral response). Those who RVR have significantly increased odds of SVR.

My first 48 hours was a complete friggin nightmare! I can laugh about it now but it was quite scary.  I took the first shot on Friday night.  By Sat I felt like I had a bad case of the flu.  By Sunday I felt completely disoriented and had a rash over 90% of my body.  My doc was on call so I called him.  He was saying we may have to discontinue tx because this rash business can be serious.  Doc said come in first thing in the morning on Monday.  I waited until either late Tuesday or maybe Wednesday to see him because the rash was improving and I wanted it to look better when I saw him (not very smart I know).  I also felt too sick to go to the doctor. lol  

Everyone's experience is different and you can't know what will happen from one day to the next.  I've never met anyone who said they had no side effects on this tx, but for some it was minimal, and they are even able to work through most of it.  I hope that is what happens for you and that you achieve SVR.  Try to relax and take it one day at a time.  We are here for you.  :)

Btw, I mistakenly had my first vl check in the 3rd week instead of the 4th and I had gone from 11 million to UNDETECTABLE.  The drugs you are on can kick some virus butt. 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
dragonfly


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Good luck, I know this is a horrible regime - take it easy.

 



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mallani


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Hi buniaminmd,

Welcome. I'd enjoy being side-effect free while you can. I presume you are Geno 1 and will be doing at least 24 weeks.

With the Incivo (Incivek) triple, the 4 week Viral Load is a great indicator of your chances of SVR, so we look forward to seeing your results.

Incivo is very potent and I hope you have minimal problems. Don't forget the 20 gm of fat! Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Scruffy


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Hiya bunyaminmd

I was on that tx, peg/riba/incivek. I had about the same reaction to the shots. They got easyer for me with time. Make sure you eat the 20gm of fat with the incivek. Don't be worried about having no side effects. I'll be honest I didn't have any untill about the third week. the drugs have to build up in your system.

Good luck on your treatment.



__________________

Geno 1a null responder 2004 inter/riba   finished incivek,peg/riba 48 weeks May 17th 2014. undetect weeks 4-12-32.  EOT+7 undetect. EOT+24 SVR!!!!! EOT+!YEAR SVR!!!!
Huey


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I Don't won't you to go without some kind of answer so I am going to give you a quick reply hoping you feel some re leaf from the anxiety.
Nothing is normal about this virus. I know nothing about your tx so i can't say, but everybody else that is taking these new meds knows they do work. Expect a roller-coaster ride in the first two weeks. and if all you get is a pony ride, feel lucky and take it.

We are all in this together Keep your stick on the ice. ;Red Green Show;

__________________

  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
bunyaminmd


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I am at third day (about 48 hours) on thriple tx with incivo.

First night, (8 hours after injection) : I chilled for 2 hours and it has past. At second day i had little muscle and joint pains. 

And now at third day. I have about NOTHING. is it normal? I am confused about tx is working or not???



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Geno: Ib VL: 495.000 , IL28 B: TT,  Age:32 Tx: naive. Started triple tx with incivo at 25th July 2014 .
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