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Post Info TOPIC: Last pill today!!


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RE: Last pill today!!
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Hi Marcy,

Congrats on finishing your trial!!!  Went in to my trial center yesterday for first follow-up appointment.  Had my first HCC scan as well.        I have been UND for a year now--SVR since July.  My coordinator said she had 25 on your trial and only 5 were on placebo.  I did ask about your enzymes going down.  She said that probably meant you were on meds BUT she is very cautious about telling HER trial participants  that it meant they were on the meds or UND.  However, she is very enthusiastic about Merck.  Like Malcolm said, Merck is not very  forthcoming with information on their trials. 

Glad you had few sides.  Think mine were caused by riba.  Just waiting to hear UND from you. 

SuziQ



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Geno 1A  Age 82 Treatment naive Cirrhotic Told I had liver disease in 1966. Diagnosed as Hep C 1999.Started Merck clinical trial with Riba on 9/9/2013 Week 1 and 2 <25  Weeks 4, 8, 12,16,18 UND.  EOT Jan 14,2014  EOT +12 UND   JULY 1 2014 EOT+24= SVR



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Hey pep

Congrats are in order for you as well, hoping all go's well in your future and your full health returns.

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 



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Pep wrote:

Took my last dose of S/O today also. Had my lab drawn and awaiting results. Good luck to both of us!!


 Fingers crossed for you too Pep!!



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Marcy

Long-term HCV, GT1a, IL28B C/T, T/G;  VL 2 mil.  Merck C-Edge Clinical trial  EOT 10/01/14. +24= UND



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Since it was a blinded clinical trial, I couldn't see the viral load.  I should know in 1-2 weeks, however my liver enzymes went way down.



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Marcy

Long-term HCV, GT1a, IL28B C/T, T/G;  VL 2 mil.  Merck C-Edge Clinical trial  EOT 10/01/14. +24= UND



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Pep wrote:

Took my last dose of S/O today also. Had my lab drawn and awaiting results. Good luck to both of us!!


 Did you have any VL test during tx? Undected then ?



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53yr M 1a acq 12/83 cirr pre tx MELD 17  tx nv diag 1/29/12  tx S/O 3/5/14  trans list.

EOT 5/28/14 UND 6/12/14 SVR 8/29/14 MELD 14 dx HCC 9/5/2014 tumor ablation 9/24/14

In the 10K lakes State It's not about us but those around us.

Pep


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Took my last dose of S/O today also. Had my lab drawn and awaiting results. Good luck to both of us!!



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58 y/o female. DX 9/12, Geno 1, Began S/O treatment 7/8/14. No prior treatments. 



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yayyyy!! what a wonderful day!!!!! smilesmilesmilesmilesmile



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 



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Hooray! Must feel wonderful to take that last pill. Good job.



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62 y/o F     Genotype 1b  for 40+ years    cirrhosis    Started Harvoni  on 11/23  for 12 weeks       UND  12/22/2014     Ended treatment on Feb 15th.

12 week's EOT viral load      <15 



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Well done, Marcy.  :)

Perhaps the C-EDGE results will be presented at the AASLD liver conference in Boston in November.   Anyone interested in the results from the C-WORTHY trial can click here:

http://www.mercknewsroom.com/news-release/corporate-news/mercks-investigational-chronic-hepatitis-c-combination-therapy-mk-5172mk



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.



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Hi Marcy,

Congrats on getting to the end. I don't understand why Merck are so silent about this combo. They must have some C-EDGE results by now, so why don't they publish them?

From C-WORTHY, your SVR chances are >90%. Good luck.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Thanks everyone!  Whatever the outcome, I am super grateful to have been part of such a wonderful supportive group.  Only people who have walked in the same shoes as others can truly understand what they go thru.   SVR or not...it's all been a blessing.

Thanks again!



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Marcy

Long-term HCV, GT1a, IL28B C/T, T/G;  VL 2 mil.  Merck C-Edge Clinical trial  EOT 10/01/14. +24= UND



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Wow Marcy, that's great that you experienced almost no Sx's during Tx.

I hope Gator Man's Johnny Carson / Carnac performance turns out to be true. smile



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57 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52,+115wks = SVR-115

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Congratulations Marcy!



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Diag. with hep c in 1992; A3:F2;  GT 1a; IL28B CT; VL 900k, ALT 150, AST 100 on 8/5/2014; SOT 9/5/2014  S/O ---VL 127 after 6 days; VL detected on day 18 but < 15.; --> UND @ EOT+ 1 year SVR!



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Thats great and best wishes for you. 



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Geno 1a null responder 2004 inter/riba   finished incivek,peg/riba 48 weeks May 17th 2014. undetect weeks 4-12-32.  EOT+7 undetect. EOT+24 SVR!!!!! EOT+!YEAR SVR!!!!



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Marcy,  I think you have the right attitude about this.  Being positive and thankful to get in this trial while being cautiously optimistic.  Hoping and praying you make it.    



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.



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Good luck Marcy!

 



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Me: 62 yr. old female, GT 1b, fibroscan 4.5; VL 650,975 as of 2/4/14;started Harvoni 3/6/15; SVR


Hubby: 59 yrs.; GT1b; fibroscan 25-cirrhotic; S/O for 12 weeks started tx 3/20/14; SVR56; fibroscan done 7-7-15 = 8.5



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Congrats Marcy,

 May this be the start of your HCV free life! That's great the meds treated you well. Good Luck!

-Rob



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Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!



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Congrats Marcy, I pray that you will be free of C in no time....as said you have really supported others now It's your turn! 

Prayers to you

Duane



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53yr M 1a acq 12/83 cirr pre tx MELD 17  tx nv diag 1/29/12  tx S/O 3/5/14  trans list.

EOT 5/28/14 UND 6/12/14 SVR 8/29/14 MELD 14 dx HCC 9/5/2014 tumor ablation 9/24/14

In the 10K lakes State It's not about us but those around us.



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Hey Marcy

Congrats on making to the end of your trial, from here your body will take over and deal with any anomalies. Stay happy and healthy

matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 

Tig


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Hi Marcy,

I'm so happy for you! You've been a strong supporter for so many of us and have handled your own Tx so well. I'm so glad you avoided the severe SFX and will keep my fingers and toes crossed for your success! We are all rooting for you and wish you the very best!!! 

Tig



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 5+ years!

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We'll be cautiously optimistic as well! Good luck, Marcy! 

I'll perform a Johnny Carson/Carnac the Magnificent impersonation and say that the answer is that SVR is in your future!smile

 



-- Edited by Gator Man on Wednesday 1st of October 2014 05:19:40 PM

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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.



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Going into the trial center today for my last pill.  This is the Merck C-Edge 1 pill, 2 drug combo.  I have to say the whole thing has been a breeze with almost no side effects.  I should know in a couple of weeks my VL.  Cautiously optimistic.  

 

 



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Marcy

Long-term HCV, GT1a, IL28B C/T, T/G;  VL 2 mil.  Merck C-Edge Clinical trial  EOT 10/01/14. +24= UND

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