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Post Info TOPIC: Sovaldi in the News
mallani


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RE: Sovaldi in the News
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Hi guys,

Waterstreet's at it again. From today's 'Sydney Morning Herald':

http://www.smh.com.au/comment/government-must-fund-sofosbuvir-and-help-hepatitis-c-sufferers-20141003-10q0s2.html



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
mallani


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Hi guys,

'Rake' is actually very entertaining. You can buy it on DVD:

https://shop.abc.net.au/products/rake-3dvd-series-3

I didn't have the Interferon effects as described, despite 4 courses ( 36 months) of the stuff.  I'm left with numb toes from a peripheral neuropathy- I can't be bothered seeing a Neurologist, as there's no treatment. It's almost certainly Interferon related, but impossible to prove. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
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Isiscat2011 wrote:

Neither have I but I noticed the Australian version is on Netflix so I'll probably be checking that out.  Maybe the US audiences don't care to see its lawyers breaking the law and misbehaving quite so much.  We have reality tv stars and Hollywood celebrities for that.  

I think the hookers were doing the pole dancing, but who knows, it could have been Waterstreet.  biggrin

 If either version has the Waterstreet character pole dancing, I think I'll pass.biggrin



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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Isiscat2011


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Gator Man wrote:

 I've never seen either the Australian or American version of Rake. I think Fox cancelled it after one season. I guess that pole dancing and hookers are kinda tough when your on Interferon. Wouldn't know-I was only on Peg/inf for six weeks.confuse

Neither have I but I noticed the Australian version is on Netflix so I'll probably be checking that out.  Maybe the US audiences don't care to see its lawyers breaking the law and misbehaving quite so much.  We have reality tv stars and Hollywood celebrities for that.  

I think the hookers were doing the pole dancing, but who knows, it could have been Waterstreet.  biggrin



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Isiscat2011


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Tig:  The Interferon/Riba/Incivek combo didn't make me depressed; it just made me psychotic.  lol  

I felt like I was having an out of body experience every day.  I felt confused and disoriented most of the time.  Hyper but lethargic at the same time if that makes any sense. I was hypersensitive to it as well.  Not everyone experiences this.  

It sure was kicking some virus butt, though.  In 3 weeks my VL went from 11+ million to UND.  

As for long term effects, it decreased my platelets so much that they never returned to normal, and elevated my glucose which also never returned to normal.  HCV can cause both of those things but it seems too much of a coincidence that they didn't happen until tx.  So sad, and so wrong, that everyone can't get on the all oral DAAs.



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Dzdayscomin


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Gator Man wrote:
Isiscat2011 wrote:

Hopefully in a positive way.   I just discovered that Waterstreet is the atty/barrister the tv series character in "Rake" is based on.  Quite a colorful character but the poster boy for bad behavior: drugs, booze, sex, pole dancing, and hookers.  biggrin

 I've never seen either the Australian or American version of Rake. I think Fox cancelled it after one season. I guess that pole dancing and hookers are kinda tough when your on Interferon. Wouldn't know-I was only on Peg/inf for six weeks.confuse

 6 weeks to many...... glad you found the better path, and now here ya are.....SVR....HEY that rhymes! 

no



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53yr M 1a acq 12/83 cirr pre tx MELD 17  tx nv diag 1/29/12  tx S/O 3/5/14  trans list.

EOT 5/28/14 UND 6/12/14 SVR 8/29/14 MELD 14 dx HCC 9/5/2014 tumor ablation 9/24/14

In the 10K lakes State It's not about us but those around us.
Gator Man


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Isiscat2011 wrote:

Hopefully in a positive way.   I just discovered that Waterstreet is the atty/barrister the tv series character in "Rake" is based on.  Quite a colorful character but the poster boy for bad behavior: drugs, booze, sex, pole dancing, and hookers.  biggrin

 I've never seen either the Australian or American version of Rake. I think Fox cancelled it after one season. I guess that pole dancing and hookers are kinda tough when your on Interferon. Wouldn't know-I was only on Peg/inf for six weeks.confuse



__________________

Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Tig


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Isiscat2011 wrote:
mallani wrote:

Hopefully it will arrange public awareness.

Hopefully in a positive way.   I just discovered that Waterstreet is the atty/barrister the tv series character in "Rake" is based on.  Quite a colorful character but the poster boy for bad behavior: drugs, booze, sex, pole dancing, and hookers.  biggrin

I could definitely relate to this comment he made about his experience with Interferon:

CHARLES WATERSTREET: Worst experience in my life. It's a drug that leads to intense depression and physical debilitation, if you're sensitive to it and I was super-sensitive to it. ... I wasn't suicidal, but I was certainly hoping someone would come through the window and stab me to death.

Who on Interferon hasn't wished that?  lol

 Holy crap! Doesn't that fit me to a tee! The first experience I had with Interferon mono therapy back in the mid 90's was horrible! I haven't watched the video mentioned yet, my PC speakers aren't so correct these days! But the experiences people have mentioned having with Interferon just give me the creeps. Like he said, he wasn't suicidal but wouldn't have minded someone doing it for him and I can relate. It was a depression that was so severe and tiring, it should be in a class all by itself, maybe it is by now (should be)... My second and final go with it was balanced by the use of an anti depressant. No way I would've even tried Interferon again without it. Had I known I was less than a year out from an all oral protocol, I know I would've waited. As it is, the Interferon has again affected me negatively. I just hope and pray that it decides to end it's negative effect on my health and does it sooner than later...

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Isiscat2011


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mallani wrote:

Hopefully it will arrange public awareness.

Hopefully in a positive way.   I just discovered that Waterstreet is the atty/barrister the tv series character in "Rake" is based on.  Quite a colorful character but the poster boy for bad behavior: drugs, booze, sex, pole dancing, and hookers.  biggrin

I could definitely relate to this comment he made about his experience with Interferon:

CHARLES WATERSTREET: Worst experience in my life. It's a drug that leads to intense depression and physical debilitation, if you're sensitive to it and I was super-sensitive to it. ... I wasn't suicidal, but I was certainly hoping someone would come through the window and stab me to death.

Who on Interferon hasn't wished that?  lol

 

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Gator Man


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mallani wrote:

Hi all,

This was on 'The 7.30 Report' last night, Australia's ABC television. This is the first time I have seen HepC mentioned on such a prestigious program.

http://www.abc.net.au/7.30/content/2014/s4098645.htm

There are a few things I can identify with Waterstreet's life, absent the fame, notoriety and partying. I wouldn't say that I spent the first half of my life trying to kill myself, but I never worried too much about diet, smoking or the beer or wine with dinner. None of these habits were uncommon in my circle of trial lawyer friends and I continued right along with them. It was several years after failing Peg/Riba tx that I realized like Waterstreet, that I needed to exercise, improve my diet and totally abstain from alcohol to deal with fatigue and other Hep C problems. Last October, I found an article written by my hepatologist and discovered that he was involved in the COSMOS trial. which seemed to offer the best chance to rid myself of Hep C. Like Waterstreet, I got lucky and can say I am SVR today. 

I thought in the past that the FDA in the U.S. topped the idiot meter. Apparently Malcolm, I am misinformed and PBAC takes the prize. Even with a ~$18k discount, Olysio over or without Sovaldi makes no sense.



__________________

Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
mallani


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Hopefully it will arrange public awareness.

What idiots we have on the PBAC- they have approved an average drug like Olysio ($66K for 12 weeks) but refused a superb drug like Sovaldi ($84K for 12 weeks).



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Isiscat2011


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This is good.  What impact do you think these efforts may have in Australia?  

Waterstreet's fibroscan score improvement was impressive as well.  

 



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
mallani


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Date:
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Hi all,

This was on 'The 7.30 Report' last night, Australia's ABC television. This is the first time I have seen HepC mentioned on such a prestigious program.

http://www.abc.net.au/7.30/content/2014/s4098645.htm



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
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