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Hep C Discussion Forum -> General Discussion -> S/O vs. S/L
Post Info TOPIC: S/O vs. S/L
wmlj1960


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RE: S/O vs. S/L
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Great news John!   According to my Dr, the chances for future liver issues like HCC gets more minimal as times passes, post SVR, so those 'peace of mind' check-up's twice yearly will continue to become just that - 'peace of mind'!  smile



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Cinnamon Girl


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Excellent news, John, I`m so happy for you...congratulations!!!  biggrin  biggrin

No words can describe the joy and relief of finally hearing the word `cured`, it`s absolutely priceless, and you must be thrilled!!

Enjoy your happy, healthy Hep C free life, and do keep in touch!  ~ Jill

Ps - Thanks for the reminder of the importance of post tx follow ups, and I`m so sorry to hear about that poor woman.  (My husband died from HCC and it breaks my heart to hear this.)



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Groupergetter


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Way to go Gman  biggrinbiggrinbiggrin   it's GREAT that you can finally put this behind you.  The occasional visits for labs and ultrasound will give continued peace of mind. 



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
Matt Chris


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Hey John

Super important story about the importance of following up our SVR with scanning for Liver cancer. A healthy live style and healthy diet is in order.

Happiness goes a long way in providing for a happy liver.

Like the quote from Eat, Pray, Love says "Smile with your Liver"

matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
jimbob


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That' great news Gater guy. That's what we all like to hear.
Also good advice on post SVR 24 check ups. Thanks!

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jimbob: 64 y/o, GT 1A, F1-F2, diagnosed 1996. Since 1970. SOT 3.5 mil VL on 3/10/14 with Sov/Rib/Peg for 12 weeks. Tx naive. UND @ week 4,8,12. EOT 6/2/14.
Gator Man


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Fireman Rob wrote:

That's great, John. I'm so happy for you. Thanks for sharing that very interesting theory on the S/O tx before Harvoni reasoning. That makes a lot of sense. It's always good to have a backup plan. I find that not retreating until  24 weeks after relapse info very interesting as my doc probably doesn't know that.

Thanks or sharing those words of wisdom and the great news!

-Rob

Thanks Rob. I was a little unclear to the extent that 24 weeks would be the duration for S/L tx 'after' 12 weeks of S/O and a relapse. I don't know if this strategy would apply to someone who failed triple therapy with a 1st gen. protease-inhibitor and Peg/Riba.



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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
suziq


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Hi Gator and All,

Just did my first follow-up for Merck.  They pay for a follow-up every six months for three years.  I also did a scan for HCC at the same time.  All was clear this time around.  Been UND for just over a year--SVR since July.  Think Malcolm posted about six month scans for cirrhotics a while back and I decided to do my Merck labs and the scan at the same time.  This isn't exactly on topic, but was responding to post on liver cancer here.  Sad story. 

SuziQ  



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Geno 1A  Age 82 Treatment naive Cirrhotic Told I had liver disease in 1966. Diagnosed as Hep C 1999.Started Merck clinical trial with Riba on 9/9/2013 Week 1 and 2 <25  Weeks 4, 8, 12,16,18 UND.  EOT Jan 14,2014  EOT +12 UND   JULY 1 2014 EOT+24= SVR
maddie


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biggrin GREAT news, Gator!!!!



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Dx. 2005-liver bx.: stg 2/gr 1. at that time  - GT 1a multiple transfusions in 1981.  Started Sovaldi and Olysio 1/16/14  (No prior treatments) Q80K present.  UND week 4,8 and at EOT.   UND at wk 4EOT, Und at wk 8EOT  SVR 12!!!..SVR 24 :-)
Fireman Rob


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That's great, John. I'm so happy for you. Thanks for sharing that very interesting theory on the S/O tx before Harvoni reasoning. That makes a lot of sense. It's always good to have a backup plan. I find that not retreating until  24 weeks after relapse info very interesting as my doc probably doesn't know that.

Thanks or sharing those words of wisdom and the great news!

-Rob



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Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!
Brownie


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biggrin  That's GREAT John! It's just what we ALL hope to hear & next month I hope to hear the same. (SVR-24) I'll heed that warning as you suggested, bc I too am a compensated cirrhotic with a fatty liver. The only "C" word I want to hear is cured.



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Huey


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LIKE !!!


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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Gator Man


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Tig56 wrote:

Gator Man!!! That's fantabulous news buddy!! I felt much better getting my 6 month report back too. Now I'm waiting for the 1 year! Getting those bits of excellent news just never get old and are always uplifting. Congrats buddy!

 

  WOOT!!!

Thanks everyone! I really didn't give the 6 month checkup much thought, but now realize that I have put HCV in the rear view mirror of life. Ultrasounds, blood work, HCC monitoring and a liver squeeze twice a year is fine with me. 

One patient anecdote discussed by my doctor is worth mentioning, although it is sad. Earlier on the same day I had my visit, he had an old patient come in who felt awful and thought she was having a recurrence of Hep C. She reached SVR several years ago, but never followed up with ultrasounds or exams even though she had compensated cirrhosis. Unfortunately, she now has HCC at stage 4 with one large mass and multiple tumors. At this point, there is little he can do.

Since we have many people who have reached SVR that are F3-F4 and many more to follow now that Harvoni is available, the moral of the story is obvious-regular ultrasounds and checkups are a must!

 



-- Edited by Gator Man on Wednesday 15th of October 2014 09:06:02 PM

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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Mugsy


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Wonderful news! Very happy for you.



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62 y/o F     Genotype 1b  for 40+ years    cirrhosis    Started Harvoni  on 11/23  for 12 weeks       UND  12/22/2014     Ended treatment on Feb 15th.

12 week's EOT viral load      <15 
Tig


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Gator Man!!! That's fantabulous news buddy!! I felt much better getting my 6 month report back too. Now I'm waiting for the 1 year! Getting those bits of excellent news just never get old and are always uplifting. Congrats buddy!

 

  WOOT!!!



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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LC


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That's great news!

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Genotype 1a, VL 1,151,923.  51 years old.  Started treatment on AbbVie TOPAZ II clinical trial Oct 10, 2014!  Undetected at weeks 2 and 4! 
Milliganus


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GREEAAAT NEWS!!!   Cured is a sweet word!  +1 to liver regeneration too.



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Marcy

Long-term HCV, GT1a, IL28B C/T, T/G;  VL 2 mil.  Merck C-Edge Clinical trial  EOT 10/01/14. +24= UND
lilbit


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Horaaaaay Gater Man. That is exciting.

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64 yo Diagnosed in 1991 with Hep C, Genotype 1a, VL close to 16,000,000, Tx Abbvie Topaz II 9/5/14, Wk 2 and 4 und. End of treatment 11/27/14 undetected.  EOT+4 und  EOT+12 und.  EOT+24 und CURED, EOT +52 now I feel really cured.
Dzdayscomin


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Way to go Gator wrestler. .....! Lol

I'm  sure this thing is ova fo you! Now as long as your remaining liver makes a 4th quarter comeback you'll  be in fine shape for the playoffs of life!

Really happy for you Mr. Thanks for being such a positive and supportive member of this community! 

May all your dreams come true!

Duane



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53yr M 1a acq 12/83 cirr pre tx MELD 17  tx nv diag 1/29/12  tx S/O 3/5/14  trans list.

EOT 5/28/14 UND 6/12/14 SVR 8/29/14 MELD 14 dx HCC 9/5/2014 tumor ablation 9/24/14

In the 10K lakes State It's not about us but those around us.
pl1952


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Congrats on that good news Gator Man!!



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Me: 62 yr. old female, GT 1b, fibroscan 4.5; VL 650,975 as of 2/4/14;started Harvoni 3/6/15; SVR


Hubby: 59 yrs.; GT1b; fibroscan 25-cirrhotic; S/O for 12 weeks started tx 3/20/14; SVR56; fibroscan done 7-7-15 = 8.5
Gator Man


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I got a call from my doctor with EOT +26 week results (I had to cancel my 24 week appt.) and I'm still UND-all lab values in the normal range. He used the c word for the first time, "cured". Hooray!!!

We were chatting about the Harvoni release and its impact on treatment. The doctor said that if I presented today as I did last December, a treatment experienced (failed Peg/Riba) cirrhotic, he would still prescribe S/O over S/L. His reasoning is that if S/O for 12 weeks didn't work, S/L could be the fallback for 24 weeks after relapse. There probably is more information regarding this that we didn't discuss, but something I would encourage anyone who is a treatment experienced cirrhotic, to discuss with their doctor. Of course this is also assumes the Utopian world of unlimited insurance coverage regardless of prescription costs.



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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
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