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Hep C Discussion Forum -> General Discussion -> Finally the results of one million test...I wonder what they mean?
Post Info TOPIC: Finally the results of one million test...I wonder what they mean?
Angel67


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RE: Finally the results of one million test...I wonder what they mean?
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Mal I learn something new each day! Funnily enough, the first Fibroscan I had went horribly wrong & gave me a score of 36! I think it was because of my "Pot Belly"! So out came the XL probes ( I didn't realise they meant  "Extra Large") and a decent reading came through. I have breathed a sigh of relief and got a grip now....I actually feel lucky to be in the state I am, things could be much worse. "Malmallani wrote:

Hi Angel,

Good results, as others have said.

Just to explain the IQR (Interquartile Range). This compares the deviation of any reading from the mean. Yours is 83% which is good, and it means the Fibroscan reading is accurate. Cheers.

 



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mallani


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Hi Angel,

Good results, as others have said.

Just to explain the IQR (Interquartile Range). This compares the deviation of any reading from the mean. Yours is 83% which is good, and it means the Fibroscan reading is accurate. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Angel67


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Those concentrated sugars are bad news, especially if a person is prone to diabetes.Matt Chris wrote:

Angel, giving up the Cola and any heavily sugared drink is a important step in controlling both HCV and Cancer

matt 

 



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Matt Chris


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Angel, giving up the Cola and any heavily sugared drink is a important step in controlling both HCV and Cancer

matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Angel67


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Thanks everyone for the prompt replies, it's like having a team of my own special doctors to furnish me with information! My Hepatologist  recommends waiting for a while ( while keeping a close eye on things). Interestingly my AST/ALT levels have halved in the past two months. The only things I can think of that may effect that are various herbs I take or sugared coca cola ( which I have now given up).



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Cinnamon Girl


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Your results are really not too bad, Angel, and I would agree with the others that you have time to wait and you don`t need to rush into a potentially difficult tx with peg/riba. 

You must be very relieved to have this information now, another step forward at least! 

So, coarse liver pâté on toast for tea as a celebration?!! wink

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Tig


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Hi Angel,

According to the Fibroscan scoring system, your level is a F1-F2, which to me is a mild/moderate level of fibrosis, IMO. Here is the scan scoring system used and is easy to understand.

Fibroscan score card:

http://commons.m.wikimedia.org/wiki/File:FibroScan_Scoring_Card_for_Liver_Stiffness_Diagnosis.png

IL28B Polymorphism is a genetic test that determines your likelihood of success when using a Interferon based treatment protocol.  The 3 types (genotypes or GT) are CC, CT and TT alleles. Yours is CT and that is right in the middle. Here is a description of the test and success rates:

http://www.ncbi.nlm.nih.gov/pubmed/20621700

The rest of your labs look acceptable. You are a Genotype 3 and the viral load is 1 million, which isn't that high, the viral load does fluctuate regularly. Mine was 5 million when I started Tx. I'm not sure how the IQR applies here, maybe someone else can explain that one. Whether or not you want to treat now or not is a decision you have to make with your doctor. It may be quite some time before the new drugs are available in the UK, unless you are selected into a study. Your fibrosis level isn't at a critical stage IMO, but it is something actively infected Hep C patients must monitor. I would use the time you have between your next appointment and (if you feel the need to) improve your health, diet and physical condition. Good luck!

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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LC


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Yay! It sounds pretty good, but I don't know what it all means either.

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Genotype 1a, VL 1,151,923.  51 years old.  Started treatment on AbbVie TOPAZ II clinical trial Oct 10, 2014!  Undetected at weeks 2 and 4! 
beingsassy


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With new drugs coming out all the time and having good numbers, I'd wait for treatment. My viral load was 19,000,000 when I started but my other numbers were good. Talk to your doctor and see if he/she agrees to wait. Interferon can be very harsh which is why I waited. I find out in a few days if my tx worked. It's your decision so do what you think is best

gigi



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genotype 2 completed sovaldi and ribavirin on 6/4/14. SVR on 12/3/14
Isiscat2011


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Hi Angel:

Not bad at all.  Your liver damage appears to be moderate.  Your VL is one million which isn't terribly high. Your Interferon sensitivity is not as good as it could be based on your CT allele.  Not as bad as it could be either--you are in the middle--I would continue to monitor and revisit the tx question in 6 months if it was me.  



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Matt Chris


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Hey Angel

I concur with your conclusion, your labs look a little elevated but are very close to normal.

You can treat now or consult with your doctor about possible future options for treatment.

Congrats on the revelation it will bring peace and calmness.

matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Angel67


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Well finally all my test results are back and they look pretty good. I am not really sure what they all mean (I can barely count to ten...thank god for my fingers!) Anyway, here they are....

Fibroscan   7.6kpa

IQR             1.1, 83% success rate

ALT              52

AST              31

AFP              12

Viral load     1000,000 ( I think, there was a strange calculation...something to the power of ten...flunked maths at school!)

Genotype     3

Platelet        157

IL-28 genotype CT/GT ( Don't know what that means?)

Moderate Fibrosis, coarse liver texture ( Pate de foie gras!)

Normal spleen size, no portal hypertension, normal clotting,normal renal functions,normal Albumin/Bilirubin,no focal lesions.

Well I think this sounds like I am in good condition considering I have had this for nearly thirty years....please correct me if I am wrong as my understanding of these figures is limited.

I go back to hospital in six months for a review...basically can I get the new drugs, should I start the interferon? This gives me some time to get fit & lose some weight.



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