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Post Info TOPIC: Stage 4 Cirrohsis


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RE: Stage 4 Cirrohsis
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I was at stage 4 and a year later fiber scan showed I dropped to 2.8 so there is hope, just keep plugging away and hopefully a new treatment will fit your situation, keep positive keep active and try to eat liver friendly food, have your medications checked to see if anything else is causing problems, good lucl



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Geno type 1  rib and peg September 2012 , 5 weeks tripple and viral down to < 15 und april Aug 25 finished stay at peg 3 rib and eprex + blood transfussion finished treatment Aug 25 2013



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Hi Steve,

It looks like you are in the same boat that I was a year ago. If you are an asymptomatic compensated cirrhotic as I am, eliminating HCV will substantially decrease the likelihood of future liver complications. At my post EOT 12 week appointment, in addition to being SVR, my hepatologist told me that I had more or less regained a normal life span. HCC is still an increased risk post SVR and some do have continued progression of liver disease, but the future outlook is greatly improved.

Your chances of being "cured" of HCV in the near future is excellent, so board the Harvoni train as soon as you can. Good luck and keep us posted.



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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.

Tig


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Hey Steve,

I didn't realize you had relapsed either! Sorry to hear that, I didn't see mention of that in your signature line. As the others have mentioned, fibrosis will continue to increase as long as there is an active HCV infection. Good luck getting this resolved, the options are far better than Incivek!

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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ss wrote:

Hello I have Stage 4 Cirrhosis. Since It has been over 5 years is it possible it is healing itself?

 


Hi again, Steven!  smile  Good to hear from you again after all this time, I`ve often wondered how you were doing!

It`s a nice thought that the cirrhosis could have been healing itself, and I like your optimistic thinking, but with an active HCV infection it`s more likely to have got worse in that time, as others have said...and sorry to have to say that.  cry

But the good news is that the new drug, Harvoni, has now been approved for use in the USA and would be a lot more effective and so much easier to do than your previous treatment.  If you haven`t already done so, please do speak to your doctor/hepatologist as soon as you can about getting the process started!

Very best of luck to you!  Jill

 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 

LC


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Sorry to hear the Incivek didn't take for you. You should be able to jump to the front of the Harvoni line though.

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Genotype 1a, VL 1,151,923.  51 years old.  Started treatment on AbbVie TOPAZ II clinical trial Oct 10, 2014!  Undetected at weeks 2 and 4! 



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Sorry, ss.  I couldn't tell you had relapsed by the signature line.  Cirrhotic livers continue to deteriorate as long as the HCV is active.  Now is the time to retreat for us cirrhotics.  As Malcolm said have a Fibroscan and keep moving forward from there.  Keep us posted.  :)



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.



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Hi Steven,

Man, it's been a while! The last we heard was when you relapsed in Oct 2012, after 48 weeks of that Incivek triple hell.

Time to get reassessed and get on Harvoni. As your HCV has been rumbling on, the cirrhosis would have progressed. You probably should get a Fibroscan.

Keep in touch. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Hi ss:

Yes, it is definitely possible to have fibrosis regression and improved liver functions once you are rid of HCV.  The only way to know for sure how your liver is doing is to make an appointment with your hepatologist and follow up with any tests he/she wants to perform.

ALL cirrhotics should continue to monitor their livers post-SVR.  We are still at increased risk for HCC and other problems although this can decrease over time as well.  You should be having periodic tests such as ultrasound, CT scan, blood work, and endoscopy.  Check in with your doc.



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.

Tig


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Hi Steve,

Good to see you again! We've had the opportunity to discuss this here recently. I know you're familiar with Malcolm, he has also mentioned some success and good news regarding his own fibrosis score since SVR. It's looking quite promising, but the research continues. Here's some info on the forum and I recommend you take time to use our search function on fibrosis regression and reduction, for some additional info. Good luck!

http://hepcfriends.activeboard.com/t57444233/impact-of-svr-on-liver-fibrosis-and-cirrhosis/

http://hepcfriends.activeboard.com/t57335146/cirrhotics-after-svr/

Tig

PS: http://www.ncbi.nlm.nih.gov/pubmed/24304452

 



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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ss


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Hello I have Stage 4 Cirrhosis. Since It has been over 5 years is it possible it is healing itself?

 

 

 



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Harvoni Started - November 23 2014

Geno 1b  Cirrohsis started incivek October 13, 2011 ended incivek on January 5, 2012

 FAILED

6 months Undetectable! 

8 months UNDETECTABLE

Last Shot Sept 7 2012.

Last Ribo Sept 13 2012

Graduated now to Post Treatment

  

 

 

 

 

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