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Hep C Discussion Forum -> On Treatment -> Started Harvoni
Post Info TOPIC: Started Harvoni
Tig


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RE: Started Harvoni
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Hi Kerry,

I just saw your introduction post and wanted to say hello and welcome you to the forum. Here's a reference to the 8 vs 12 week protocol. If your VL were below 6 million, the new rule is for 8 weeks. I believe you're going to do well on this. Your viral load while considered high, isn't considered a negative concerning your likelihood to achieve SVR. Your VL fluctuates regularly and is affected +/- by your immune response pre treatment. Here's a chart and the link:

Treatment duration

  • Treatment-naïve with or without cirrhosis: 12 weeks
  • Treatment-experienced without cirrhosis: 12 weeks
  • Treatment-experienced with cirrhosis: 24 weeks
  • Note: 8 weeks can be considered in treatment-naïve patients without cirrhosis who have pretreatment HCV RNA <6 million IU/mL
  • http://reference.medscape.com/drug/harvoni-ledipasvir-sofosbuvir-999970
  • Good luck, Tig
  • PS: I deleted your duplicate post...


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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Knorman


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My Kaiser GI Dr. Says the duration of treatment is base on your current VL

 

Im at 8 million so I'll be on for 12 weeks



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Cinnamon Girl


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Hi JoAnne, good to hear from you!  smile

The length of treatment with Harvoni depends on whether the person has previous experience of tx and whether or not they have cirrhosis.

These are the basic protocols...

Tx naive w. or w.o cirrhosis  = 12 weeks

Tx experienced w.o. cirrhoshis = 12 weeks

Tx experienced with cirrhosis = 24 week

So if this is your friend`s first treatment then he is on the right tx duration whether or not he has cirrhosis, or if he has done tx before but is not considered to have cirrhosis.

Hope that helps, and all the best of luck to him! 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
JoAnneh


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I am confused about length of treatment
on Harvoni.
I Acheived SVR on Incikex 2 years ago.
I have been sober 28 years and have
A friend that I used drugs with as a teenager has
Started Harvoni for 12 weeks. .
He has not had a biopsy due to no insurance.
He is sober now for 5 years.
Should he be prescribed 24 weeks.
Any feedback appreciated as this forum
Was my life line on treatment.



-- Edited by JoAnneh on Thursday 19th of February 2015 07:05:52 PM

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JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
Beacon


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Bob,

Yeah I don't try to get too technical about my cardio so far, just easy jogging, get my heart pumping

about 3 times a week. As you know it takes some motivation and for me that's trying to hold

all these other diseases at bay. The little I do really helps with my numbers. It's day 5 for me

on Harvoni and so far no side effects that I can blame on the pills. I'm hoping it stays like this.

 



__________________

GT 1a, was tx naïve, cirrhotic(Fibrosure), 64 y.o. Started Harvoni 12/12/14 for 12 wks. EOT weeks 4, 13, and 24 HCV not detected! HVC not detected EOT plus one year.

A smooth sea doesn't make for a skillful sailor.

 
Bob54


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Beacon wrote:

Bob,

I have also been on a cardio routine (walk, run, walk) in the park up and down hills. I been doing it for

nearly one year and it has really helped all of my bloodwork even my liver functions are better.

I just started on Harvoni last 12/12/14 but I think this week I'm going to take it easy and

not exercise and next week maybe ease back into if I'm still feeling good.

 Hi Beacon,

Sounds like we're pretty near on the same page. I do about 2-3 miles every other day for 7 days (run,walk,run). Started last January after some pretty high Cholesterol results. Bought a heart rate monitor and keep my heart rate above 130, below 160 for a half hour.  I do a 30 min Upper body with dumbells on in-between days.  Has also worked wonders on my Bloodwork.  I am going to drop the last cardio day for a little while and see what that does for me.  I'm still having the Dry eye problem. Seems to be the only issue right now.  Good luck to you and keep posting.



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60 yo; genotype 1b; VL: 11,000,000; No Fibrosis; Diagnosed Dec 2008; Treatment naive until Dec 8, 2014, started Harvoni/completed Tx Mar 1, 2015; awaiting test results.
Beacon


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Bob,

I have also been on a cardio routine (walk, run, walk) in the park up and down hills. I been doing it for

nearly one year and it has really helped all of my bloodwork even my liver functions are better.

I just started on Harvoni last 12/12/14 but I think this week I'm going to take it easy and

not exercise and next week maybe ease back into if I'm still feeling good.



__________________

GT 1a, was tx naïve, cirrhotic(Fibrosure), 64 y.o. Started Harvoni 12/12/14 for 12 wks. EOT weeks 4, 13, and 24 HCV not detected! HVC not detected EOT plus one year.

A smooth sea doesn't make for a skillful sailor.

 
Tess


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Bob54 wrote:

Completing week 1 today, nothing significant to report despite my anxiety at the start. Did have a problem with gas (embarrassing but real). I think it was a combination of my daily vitamin E supplement and Harvoni. Stopped taking the supplement on Day 2 and the gas stopped. Have also noticed a dryness in my eyes lately. Don't know if that's the weather change or TX. Have continued my exercise regimen i spoke of previously and haven't experienced any negative effects. All in all feeling pretty good about this.

 Hey Bob,

Congrats on starting Harvoni!  You mentioned dry eyes and maybe it's a coincidence, but at an eye exam last week the doc noticed dryness in my eyes.  He wants to see me again in 3 months because he wants to find out if it's related to the Harvoni (I'm 18 days in).  I hadn't heard of it being a side effect but maybe it is.  It would be interesting to hear if anyone else has come across that as a SE.

Take care and best of luck!

- Tess 



__________________

HCV Gen 1a diagnosed 2001; Labs 11/13/14: VL 1.2 million IU/mL, ast 88, alt 111. Harvoni TX 12 weeks.  EOT - 2/18/15, VL UND & normal ast/alt.

4 wks after EOT, VL = UND; normal AST/ALT at 4, 8 and 14 weeks after EOT.  15 weeks after EOT = Undetectable!
Matt Chris


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Hey Bob

Good to hear from you after the first week, I think its a good idea to get your pulse rate up and move the blood around.The Tx has to reach all the areas in the body IMO a patient on treatment should move / exercise during not only treatment but the rest of there life.

Welcome to the Harvoni treatment train.

matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Bob54


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Completing week 1 today, nothing significant to report despite my anxiety at the start. Did have a problem with gas (embarrassing but real). I think it was a combination of my daily vitamin E supplement and Harvoni. Stopped taking the supplement on Day 2 and the gas stopped. Have also noticed a dryness in my eyes lately. Don't know if that's the weather change or TX. Have continued my exercise regimen i spoke of previously and haven't experienced any negative effects. All in all feeling pretty good about this.

__________________

60 yo; genotype 1b; VL: 11,000,000; No Fibrosis; Diagnosed Dec 2008; Treatment naive until Dec 8, 2014, started Harvoni/completed Tx Mar 1, 2015; awaiting test results.
Bob54


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Thanks Cinnamon Girl, I tried to delete one but couldn't. Thanks you all for the input.



-- Edited by Bob54 on Wednesday 10th of December 2014 01:27:15 AM

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60 yo; genotype 1b; VL: 11,000,000; No Fibrosis; Diagnosed Dec 2008; Treatment naive until Dec 8, 2014, started Harvoni/completed Tx Mar 1, 2015; awaiting test results.
Mugsy


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Hey there, Bob.    I have been on Harvoni for over 2 weeks now.  We are all different in our reactions to Harvoni and I'd add that you should listen to your body and adjust your exercise level according to how it makes you feel. The first week/10 days seem to be when the side effects were the strongest for me. I had headaches, joint pain, nausea and a bit of insomnia. So if you aren't up to the previous level of exercise, cut back a bit and adjust as you get to feeling better.  Maybe change to walking or swimming for a couple weeks and then return to your previous regime, slowly. I am no expert, but this seems reasonable to me.

 

Good luck to you.

 

Mary



__________________

62 y/o F     Genotype 1b  for 40+ years    cirrhosis    Started Harvoni  on 11/23  for 12 weeks       UND  12/22/2014     Ended treatment on Feb 15th.

12 week's EOT viral load      <15 
Cinnamon Girl


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HI Bob,

Welcome to the forum and thanks for introducing yourself in the New Members` Area.

I don`t have any personal experience of Harvoni either but I would say follow your doctor`s advice to decrease your exercise routine a little, certainly for the first couple of weeks, to see if you have any side effects from the medications.

On the whole it`s good to keep up some sort of exercise while on any treatment regimen, and in your case there are medical reasons for continuing with it, but just ease up a little would be my suggestion and see how it goes.

Best of luck with your treatment!  

(Ps - I`ve joined your 2 threads with the same heading together so that the replies are in one place, hope you don`t mind.  Jill) 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Tig


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Hey Bob,

I can't speak from experience with Harvoni, but have to believe you're your own best judge. You sound like you have a good exercise regimen and are committed to it. However, as your doctor suggested, you might want to consider reducing the reps or overall time committed to the program. I think from the other comments here from Harvoni and Sovaldi patients, you will likely be able to tell some of your limitations in a couple of weeks at most. I might suggest cutting your routine in half, now and then seeing how you feel in two weeks. If you experience no extra fatigue at that point, you could either choose to bump it up a little or decide that for the next 10 weeks, the abbreviated schedule equals your doctors suggestion of "toning it down". Either way, it's a good idea to keep some of that energy in reserve during treatment. You never know how your body is going to react to these medications. Good luck Bob, the time will go by fairly quick and you'll be able to return to your full schedule when the time is right!

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Harvoninme


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Hi Bob. Welcome & grats on starting treatment. A few people seem more sensitive to the side effects of Harvoni than others. Most seem to be breezing through treatment. I would let my body be my guide.

Best wishes  for a quick, happy treatment!



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Bob54


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(duplicate post...edited by Jill)



-- Edited by Cinnamon Girl on Tuesday 9th of December 2014 08:54:07 PM

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60 yo; genotype 1b; VL: 11,000,000; No Fibrosis; Diagnosed Dec 2008; Treatment naive until Dec 8, 2014, started Harvoni/completed Tx Mar 1, 2015; awaiting test results.
Bob54


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Started a 12 week course of Harvoni on Dec 8, so this is day 2.  Have some questions about exercising if anyone can help out. Last year about this time I had very high cholesterol readings along with blood levels approaching pre-diabetic ranges. Caused a serious change in diet and eating habits as well as starting an exercise regimen that I have so far stuck to pretty religeously. Prior to starting Harvoni, over a 7 day period, I did 30 mins of cardio every other day, and did a 30 min upper body workout on the days in between, then took 2 days off. I am currently on those two days off and intend to get back to it tomorrow. Doctor advised me to tone it down a bit so my body has the energy to help fight this disease, but as I reach that moment, gotta admit I'm not sure i know what tone it down means. Has anyone on Harvoni dealt with this type of issue? On the one hand I'm dealing with Heart health and diabetes, on the other, whipping this Liver disease. Any thoughts out there? Cholesterol and blood levels are all back in normal ranges.       



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60 yo; genotype 1b; VL: 11,000,000; No Fibrosis; Diagnosed Dec 2008; Treatment naive until Dec 8, 2014, started Harvoni/completed Tx Mar 1, 2015; awaiting test results.
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