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Thanks mallani. Sounds to me like the filter would work best  if used in conjunction with RX to reduce the VL to help the RX eliminate the virus. Time will tell how the filter works out. Less money for the pharmaceutical companies in it's use if it reduces the amount of RX needed for a cure.  Still hope abounds for advances in treatment.  



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Hi and welcome James.

Sorry you relapsed on the Sovaldi/Riba. It happens.

You've had some good advice, and you really need an accurate liver staging. Fibroscan is OK, but Geno 3's have a tendency to fatty liver, and I would want a biopsy.

The Hemopurifier sounds fun. If only the virus was just in the blood! More than half the viral components are hanging out in hepatocytes and other tissues. It's a dream.

You need to wait until a pan-genotype regime becomes available. As you said, GS-5816 sounds promising, as does MK-5172.

Geno 3 is pretty common in Australia, and we have a bunch of Rx- failed cirrhotics waiting for something good. We can't even get Sovaldi.

Good luck. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm

Tig


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Hey James,

Thanks for the links to those articles on the Hemopurifier Device. That study was approved and I'm interested in how that's progressing. Wouldn't that the ticket? Just plug in and perfuse your way drug free to SVR! Now you're talking!

http://aethlonmedical.investorroom.com/2013-06-25-Aethlon-Medical-Announces-FDA-Approval-of-IDE-to-Treat-Hepatitis-C-HCV-Patients

I also believe it would benefit you to have another biopsy or fibroscan. You'll be able to bring that up next visit. RC makes a good point on advanced fibrosis and GT 3. He experienced similar relapse as you. He's a great person to talk to. In the meantime, keep up the great attitude and take care of the things you're able to. Your time is just around the corner! Good luck...

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Thanks for the article Tig56. Seeing as the Biopsy was done around 11 years ago I have no true measure of the condition of my Liver. The Gastro Dr. declined to do one if I started the Svld/Rbvn treatment. Now that that has failed I would think another biopsy would be prudent to check the present condition of my Liver. For now I will continue to watch my diet and exercise and wait for the next advances in treatment. I don't know if you have seen this but here is a link to a article on a new device you may find interesting it also gives me hope for another advance in treatment.   http://www.medgadget.com/2014/10/aethlon-hemopurifier-now-filtering-blood-of-ebola-patient.html    http://www.medgadget.com/2013/06/hemopurifier-to-be-studied-as-treatment-option-for-hepatitis-c.html   Thank you for the support with a little help from our friends we will all get through this. 



-- Edited by inthewind on Wednesday 10th of December 2014 01:41:07 PM

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Only Biopsy done in 2003 no other test than normal physical every year. I have seen where GT3 could fail because of Steadosis , Fibro, or Cirrhosis.  



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James, Welcome to the forum.  Your not alone.   I did solv-riba  16 weeks and  relapsed at end of treatment also.   I"m gt-3  f3-f4     Do you have any fibro scan or biopsy results?  They may explaine your relapse ?  Us type 3 folks seem to be hard to cure W/cirrhosis   We need to keep a close eye on treatments coming down the pipeline, and keep your doctor informed.   Best of luck-treatment to you    RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   

Tig


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Hi James,

I found this Medscape article on GT 3 that you may find interesting, I did. It goes into the nitty gritty of the old SOC's,  as well as the new DAA's against it. Hard to say what might be the next recommended protocol, perhaps Daclatasvir?  You haven't treated with IFN, so that could be a consideration, but that's a discussion for you and the doctor. If you're not satisfied with your healthcare team, it might be worth your time to discuss your possibilities with another specialist. There are several opportunities coming available and depending on your individual case, you may have the time to wait. 

http://www.medscape.com/viewarticle/823712

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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In 2003 my VL was 80,000 had a liver biopsy in 2003 showed no damage. When i was retested in 2013 VL 2,000,000 my VL at retest 12 weeks after I finished the meds was 220,000. No other test have been preformed other than enzyme testes. They were normal during treatment after first four weeks of treatment, Before that they went up and down. I didn't have any side effects from the treatment. I never missed a dose and took them everyday at the same time with in a 30 to 60 minute window. Mornings between 5 and 6 am Sovaldi and Ribavirn evenings between 5 amd 6 pm. Rivavirn. Didn't hear anything from Dr. until I contacted them had to request an appointment nurse said she didn't know if Dr. would want to see me or not. Took about 3 weeks to get them to schedule my visit. Not sure what was up with that. I just changed my PCP wasn't happy with his not keeping track of my HCV and may change Gastro Dr. too before it's over.  



-- Edited by inthewind on Wednesday 10th of December 2014 02:54:34 AM

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inthewind wrote:

Hello all I'm new. GT3 believe I've had HCV since late 1970s from tattoo. Was diagnosed 2003 was told it was mild not to get treated. My Dr. was to monitor it with my yearly physical but it didn't happen was tested again in 2013 and went through SLVD/ Rbvrn 24 week treatment 03/2014 - 08/2014 post treatment tested in 11/2014 am not virus free. Waiting to see a Gastro Dr. again can't get back in until 01/2015 to see one. Feeling pretty hopeless right now but have decided this is the hand I was dealt and will play it the best I can. Hoping the new Sovaldi/ GS-5816 will be FDA approved and for GT3 patients. Here's to all of  us getting cured.    


 Howdy. I'm sorry to hear your previous treatment did not work. :( This a good place to hang out through the holidays and gather information for your next appointment. Welcome. :)



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Tig


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Hello James,

Welcome to the forum! I'm sorry to hear about your relapse. That has to be difficult to understand, it is for me. You did everything right, great protocol and 24 weeks to boot! It was a failure of the medication, not you. I know that doesn't help much right now. I invite you to provide us with a little intro. I'd be interested in knowing more about your treatment history. Labs, etc are always interesting and helps us understand your struggle better. 

I'm glad you found us and hope you stick around. We've got a great group here and I'm hoping you will keep us informed on your progress with treatment. I'm curious about your doctors response when You get back in. Have they mentioned anything to date? This has to come as a shock to them too! GT 3 is becoming one of the tough genotypes to tackle, but protocols are improving and your turn is coming. Hang in there and keep the faith! We're here to talk...

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Member

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Hello all I'm new. GT3 believe I've had HCV since late 1970s from tattoo. Was diagnosed 2003 was told it was mild not to get treated. My Dr. was to monitor it with my yearly physical but it didn't happen was tested again in 2013 and went through SLVD/ Rbvrn 24 week treatment 03/2014 - 08/2014 post treatment tested in 11/2014 am not virus free. Waiting to see a Gastro Dr. again can't get back in until 01/2015 to see one. Feeling pretty hopeless right now but have decided this is the hand I was dealt and will play it the best I can. Hoping the new Sovaldi/ GS-5816 will be FDA approved and for GT3 patients. Here's to all of  us getting cured.    



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