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Hep C Discussion Forum -> General Discussion -> Should we screen for NS-5A RAV's?
Post Info TOPIC: Should we screen for NS-5A RAV's?
maddie


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RE: Should we screen for NS-5A RAV's?
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Very interesting stuff, Malcolm.  Thanks



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Dx. 2005-liver bx.: stg 2/gr 1. at that time  - GT 1a multiple transfusions in 1981.  Started Sovaldi and Olysio 1/16/14  (No prior treatments) Q80K present.  UND week 4,8 and at EOT.   UND at wk 4EOT, Und at wk 8EOT  SVR 12!!!..SVR 24 :-)
mallani


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Hi all,

At the recent EASL Meeting, Lawitz presented a paper on 24 weeks of Harvoni for previous treatment failures. The following comment caught my attention: ' Patients with no baseline NS-5A RAV's experienced 100% SVR12. Those with baseline RAV's reached SVR12 at 60%' . Also, it was found that 25% of treatment failures had the Sovaldi RAV S282T. Gilead have always maintained that S282T is not a problem. It obviously is, in the real world.

This raises the question: Should all treatment failures (with DAA's) be tested for NS-5A RAV's, prior to starting a new round of treatment? If RAV's are present, should they wait for the new Merck combo to be approved.

http://www.healio.com/hepatology/hepatitis-c/news/online/%7B7800fe7d-b339-4eaa-93bb-339b6f74dfc4%7D/previous-treatment-failures-respond-to-24-weeks-of-harvoni



-- Edited by mallani on Sunday 26th of April 2015 03:06:55 AM

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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
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