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Hep C Discussion Forum -> On Treatment -> harvoni and riba
Post Info TOPIC: harvoni and riba
bubble


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RE: harvoni and riba
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Hi John. So sorry to hear about the relapse also. I think you will have much, much, better sucess with the new nucleotides. I am glad it's over for you though. Look on the bright side as always, your not going to do interferon anymore. The new treatments are so much tolerable then pumping that "ice" in a needle in your body. You will do better this time as alot of us here know too. Keep in touch. Good Luck.



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60 yrs. Geno1b 2001. 9mil. VL. �Failed Post Riba/Peg tx. 2006 46 weeks. Diagnosed 1A 2015(?) F3 fibr. 225k VL. Vikera/Riba 12 weeks 3/20/2015. "Undetected" start to finish. Undetected 1yr post tx.
Cinnamon Girl


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Yes you`re so right about the new drugs, John, nicely put!  We`re moving into a new era of treatment now and it`s a wonderful thing to see so many people coming through and being able to ride that train to SVR.

The prescribing details for Harvoni state quite clearly that tx experienced people with cirrhosis need 24 weeks and your doctor should know that already, but if you need to insist then do it! 

You must be very relieved that your wife is doing so well, is this her first treatment?

Ps- Yes, I`m doing well, thanks for asking, and have just come back from a little trip to Ireland!



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
newmex


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Thanks Jill, yes am very happy its working so good for wife, only very minor side effects, and already undetected. I am going in this morning to see Doc and will shoot for the 24 week program, I guess its a cost saving plan to try the 12 weeks with the riba, and but this has consumed my life for the last few  years and I want it over, as every one else here does. Thanks again, and hope every thing is going well for you, Glad to see the new drugs are working out so well for every one, its is amazing the progress they have made it the last couple years. Seems like the old treatments people were having to pull the train, now with the new stuff you actually get to ride it, lol . Am looking forward to it.



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John
Cinnamon Girl


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Oh John, I`m really sorry you`ve relapsed after all you`ve gone through.

I know it must feel like such a disappointment but the next round with Harvoni will do it and it will be so much easier.  I agree with the others, you need 24 weeks to be sure of clearing the virus for good.

Congrats to your wife, you must be thrilled about her UND result after only 2 weeks, Viekira Pak works well and works fast!! 

Keep your chin up, you did well getting through the incivek triple, it`s a punishing regime as we know.

Wishing you all the best...  smile

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
newmex


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thanks every one. Mallani platelets are about 130 just a little low. Am being treated at VA so and go see them again Thursday, so will have more details after that. Any one else here on Harvoni through VA? Wife also on treatment, she is on vikiera, and got her 2 weeks results today and already undetected, Wow, some potent stuff!!



-- Edited by newmex on Thursday 7th of May 2015 04:34:53 AM

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John
Groupergetter


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Hi John, truly sorry to hear of the relapse.  That's a real kick in the.........gut.  As others have said, 24 weeks is the recommended tx for those with cirrhosis.  If necessary I would push for it.  Good luck



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
Matt Chris


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Hey John

Sorry to read of your 6 month lab report, as far as re-treatment being that you are cirrhotic and failed previous treatment 24 weeks would be what I would insist on. I would make the case that both the FDA guidelines on Harvoni and the AASLD recommend 24 weeks. Some doctors are using Riba with 12 weeks of Harvoni but the extra 12 weeks can make the difference for relapsed patients. With even some hard to treat patients like some of us on the forum ( myself included) include Riba with Harvoni for 24 weeks, with the clinical trials showing an 1% to 5 % increase in the SVR rates with RIBA added.

matt   



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Gator Man


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Hi John,

I certainly agree that you should insist on 24 weeks of Harvoni. Ro is a good example of how effective it can be after the full duration!

Good luck and keep us posted.

john



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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Scruffy


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Sorry for your relapse John. That stinks. I can't speak on how long you should treat for but I'll be cheering for you.



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Geno 1a null responder 2004 inter/riba   finished incivek,peg/riba 48 weeks May 17th 2014. undetect weeks 4-12-32.  EOT+7 undetect. EOT+24 SVR!!!!! EOT+!YEAR SVR!!!!
Ro


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I also am 1a and cirrhotic. I have had the same experience with Incevik triple therapy.. undetected... then broke through and viral load went soaring.   2 years later I have completed 24 weeks of Harvoni 2 weeks ago...... I have been undetected since week 4.. 

Hope it all works out for you.

Ro



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Tig


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Hey John,

I'm sorry buddy, that's a tough one to take. You battled hard and lived through Incivek as well. Harvoni for a treatment experienced cirrhotic is 24 weeks. Riba may make a difference but over 24 weeks, I agree it's probably not necessary. There's a new protocol coming late this year or early 2016 from Gilead, Sovaldi and GS5816. It's already showing a lot of good results over 12 weeks of Tx.  But should you get approved for Harvoni, I'd definitely want to go for 24 weeks.

Good luck John,  I'm glad you let us know. Keep us updated and hang in there. 



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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mallani


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Hi John,

Very sad to hear the 48 weeks of Incivek triple didn't work for you.

As a treatment experienced cirrhotic, I'd want 24 weeks of Harvoni. Not sure the Riba is necessary. What are your platelets now? Cheers mate, you'll get there.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
malekula man


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Hi John,

Really sorry for your relapse. It's happening.
12 wks Harvoni + Riba is not an official regiment.
Basically for treatment experienced patients Harvoni is prescribed for 24 weeks without riba (Gen 1). If your insurance company is OK with 24 wks - why not? My doctor says they prescribe 12 wks Harvoni +Riba in case the insurance covers only 12 wks. The final result is pretty same but better if you push for 24 wks Harvoni. Key phrase is "pretty same"...

Good luck!
MM

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G1b, stage 4, cirrhosis

Harvoni Tx: Jan-Jun 2015 for 24 wks, SVR12, SVR24

PrevTx : relapser, Sovaldi +Peg+Riba for 12 wks, Jun-Sep 2014

My thread
newmex


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just got my 6 month eot results after the 48 teleprevir/riba/interferon voyage. Hmmm seems it still isn't gone have an 80, 000 vl  now. Docs have told me I will go on 12 week harvoni and riba. is this long enough of should I push for the 24 week?  I was undetected after about 4 weeks on the teleprevir and throughout treatment so was sure I had it licked. Have cirrhosis, 1a. Any ideas on duration?



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John
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