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Hep C Discussion Forum -> On Treatment -> Can someone please "Clarify what would cause a RELAPSE after clearing the virus?"
Post Info TOPIC: Can someone please "Clarify what would cause a RELAPSE after clearing the virus?"
Femapples


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RE: Can someone please "Clarify what would cause a RELAPSE after clearing the virus?"
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Are you discussing the relapse rate for naïve treatment?  I believe it's 1 or 2% more for people who have been previously treated.

F.



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Hep C, viral load 26,000,000, monoclonal gammopathy of undetermined significance (kidney), glomerulonephritis (kidney). 1994: Interferon, 2005: Interferon & ribavirin, 4/1/ 2015: Viekira Pak & Ribaviron, 12 weeks EOT: virus UND
hepCFREEwanab


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We went to see Angelo's Hepatologst and he wants Blood test done after 4 weeks EOT.

He said that if after 4 weeks he's still  UND that is a pretty good indication that he is in 98% group that achieves SVR!   The other 2 % are the people that although have been UND for a while, meaning that the virus has cleared the blood,  any trace left behind in the liver could trigger a relapse!

So waiting for 12 weeks to check after EOT how well the treatment really went, it's a bit much!

So, he finished on May 10th, next blood work after 4 weeks on June 8, then finally at 12 weeks which by coincidence is his Birthday! 

Mena



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Genotype 1b, V/L  0! Finally got rid of the Dragon after 24 wks. of Harvoni.

EOT 5/10/15   - 4 wks. UND, 12 wks UND, 24 wks. UND!!! 
basser


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think the only chance of the virus surfacing again after getting svr is reinfecting.as i dont do anything that would cause reinfecting myself cant see any reason for a relapse.but is early days and there is still a lot of confusion around the whole issue of hep c.all i can do is look after myself with a gd diet/ exercise and sleep.am still recovering from effects of meds and damage done from having the virus for about 25yrs.thts enough to be getting on with for now. best of health to you all                                                                                                        williamsmile



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 william.61 yo.lives in uk.geno 1b.started sol/dac/riba sept 2014 12wks.am now svr and now had liver transplant on 19/07/ 16
hepCFREEwanab


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Tig56 wrote:

Hi Mena,

The documented rate of relapse following SVR is <=1%. The feeling is that may even improve over time but nothing concrete. So there is a remote chance of relapse but it's so rare it isn't  discussed. The feeling is once you achieve SVR, you're done. Re infection is different and is thought to be far more common than a relapse from the original infection. 

How's Angelo? I hope you are both doing well.

 This is exactly what I thought. Thanks Tig.

Angelo is doing pretty well , finished Harvoni on May 10 .  Up to that day all blood results showed UND.

Tomorrow he has an appointment with his regular Hepatologist and on June 17th he goes back to Mt. Sinai for a follow up MRI. to see if hopefully the tumors have shrunk even more.

Will post any updates.

Mena



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Genotype 1b, V/L  0! Finally got rid of the Dragon after 24 wks. of Harvoni.

EOT 5/10/15   - 4 wks. UND, 12 wks UND, 24 wks. UND!!! 
Tig


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Hi Mena,

The documented rate of relapse following SVR is <=1%. The feeling is that may even improve over time but nothing concrete. So there is a remote chance of relapse but it's so rare it isn't  discussed. The feeling is once you achieve SVR, you're done. Re infection is different and is thought to be far more common than a relapse from the original infection. 

How's Angelo? I hope you are both doing well.



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Tig

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Matt Chris


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Hey Mena

How are you two doing these days? Are you currently in treatment or have you finished?

Sometimes HCV members/patients received test results during treatment or at the end of their treatment to see if the virus is detectable or NON-Detectable. From a results standpoint if this comes back as not-detectable this a very good thing, but not the same as clearing the virus or SVR-12.

Most Doctors and HCV specialist consider SVR-12 (12 weeks after treatment ends still undetectable) or longer SVR-24 as a cure or clearing the virus from the body to the point where your own immune system can handle any minute amount that may remain.

If you attain SVR-12 / SVR-24 status the odds are about 1% or 2%  that you could relapse from the original infection, if you for some crazy reason re-infected yourself via blood contamination or IV drug use you could end up with a new case of HCV.

hope this clear up some questions.

matt 



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61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
hepCFREEwanab


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It is my understanding that the only way to relapse after clearing the virus, would be if that person were to be "Reinfected again"!  

Am I wrong?

Mena



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Genotype 1b, V/L  0! Finally got rid of the Dragon after 24 wks. of Harvoni.

EOT 5/10/15   - 4 wks. UND, 12 wks UND, 24 wks. UND!!! 
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