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Post Info TOPIC: New here and on clinical trial
robertsamx


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RE: New here and on clinical trial
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247, as a fellow type 3, and after failing treatment with sof-riba, I will be watching this trial and your results. Please keep us posted. There is no advantage of being a type 3  because we seem to be the hardest to treat,and if you add cirrhosis  to the mess you deffinatley want riba.   When I was diagnosed as a 3  in 89 or 90 ??I was told that was the best one to have and the easiest to treat. That was then, thay had just started geno typing hep c.  Back in the early days  (late 80"s to early 90"s) they just called it non a  non b    I thought i had lucked out with the type 3 diag.  I even put off treatment because they  said i had the easy one to treat.  But to be honest about it  I just did not want to have the flu for 48 months and was told I could wait for easyer treatments and that riba was just about to be unvailed and was the answer for better cure rates.  Type 3"s dont show well in trial results so we kinda have been put at the back of the bus. But now that 1a and 1b have such a good svr , they will start more trials on us 3"s.   hang in there!!    RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
247kath


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Hi All

Yes that is the trial. i guess there is an advantage to being a less common genotype!! There is room for 100 people across Canada for this trial and it looks like they're still recruiting.



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Treatment naive -Genotype 3a -no fibrosis. Found out in 90's that I had HCV. Started clinical trial June 9/15 Harvoni/ribavirin
Cinnamon Girl


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Hi Bill,

As it stands at the moment Harvoni is only approved for treating Gen 1 and Kathy`s trial is for people with Gen 3.   Gen 3`s don`t tend to respond as well to the new DAA drugs unless ribavirin is added to increase the success rates.  So this trial will provide very useful data for possible future treatments with Harvon for those with Gen 3. 

Here`s a link to the trial I think she is doing...

https://clinicaltrials.gov/ct2/show/NCT02413593?term=gilead+harvoni+and+ribavirin&rank=2

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Bills


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Hi Kathy

That sounds like good a Trial  Harvoni alone is winner. Adding Ribavirin is insurance. many people here have done Riba. It sucks but it's not the worst of the drugs used.

I'll go out on limb and ask something for the more knowledgeable people.

Basing it on a pattern I see Do you think this trial is really testing the effectiveness of using Riba or not?   My Doc said he felt there was not much difference in results for Harvoni with or without Ribavirin.

I am not knocking this trial I would have done it in heartbeat before Harvoni was released I was begging for something like this.

Another Plus  Kathy is  trials are Free ( most times )  not to mention when on a trial the docs are watching every move so you get best of care  they treat you special. It's also good your NOT in a Blind Trail ( when they don't tell you the viral load and very little all around).  If you've seenVL then it's NOT Blind.   I was a Lab rat once too.

You'll do fine Kathy you have a winning combo

BillS

 



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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.

Matt Chris


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Hello Kathy

Welcome to the forum from me as well, you have found a good place with members who have great insight on all things HCV. Hope you have good results during and after your trial.

matt

 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
wmlj1960


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 Hi Kathy.

I would also like to welcome you to this very helpful forum. When I first sought treatment for my Hep C it was suggested that I get educated and get involved. This forum is, for the most part, where I learned to do that and I'm glad I did. So make yourself at home and join us all in our journey to beat the Hep C dragon. smile



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Cinnamon Girl


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Hi Kathy, that's brilliant news! So pleased you've got off to such a great start to your treatment, very pleased for you! smile

 

 

 

 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Tig


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Outstanding Kathy! You will certainly be undetected following your next test. You are responding exactly the way we like to see and better than many, considering it has only been one week. Congratulations is in order! You've got the Dragon on the run already, woot!!!! smile



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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247kath


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Thank you for the welcomeWas away for a few days. Weekly check in yesterday at hospital and viral load had been over800,000 at start and after one week had dropped to 31. OMG unbelievable! The emotion that came over me brought me to tears. After discovering that I had HCV 20 years ago and now to realize it could be gone was overwhelming. I had never realized how much it pressed on my mind until that moment. Grateful beyond belief.



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Treatment naive -Genotype 3a -no fibrosis. Found out in 90's that I had HCV. Started clinical trial June 9/15 Harvoni/ribavirin
robertsamx


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found the trial you are on, that should do it for you.  Congratulations on geting into that one. RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
robertsamx


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welcome 247     Harvoni and riba are a strong T/X  .wishing you the best of luck   . I was wondering what trial youy were on and would like to know more about the trial.    This forum has a lot of answeres.   RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
coolheat


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Glad you're here, seems no matter what, all or any participation is helpful to everyone.smile  CH   Look forward to hearing your successes.



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65 YO F, GT 1a1b, ast 14 alt 21, fibrosis 3/4 DX 1968 non a or b, TX 12 wks Harvoni, SOT 6.1.15, 1st bld wk: detected unquantifiable EOT 8.28.15 detected unquantifiable, 3 mo.EOT mid Nov.~SVR 12: ) UNDETECTED
247kath


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Thank you! New to using a forum and kind of private person so hope I can add a bit to it. 



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Treatment naive -Genotype 3a -no fibrosis. Found out in 90's that I had HCV. Started clinical trial June 9/15 Harvoni/ribavirin
Tig


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Hi Kathy,

Welcome to the forum, I'm glad you're here! You will meet a lot of good people and everyone is always willing to help. You will be hearing from them soon and if you need anything, let us know.

You're on a very effective protocol and 12 weeks of it have proven very effective for all fortunate to get it. What is the name of your trial? Have you treated before? There will be some questions and any information you can share will help us provide better informed opinions and suggestions, should you desire them. 

If you haven't checked out our Forum Information and Knowledge Base sections, you will find a lot of helpful information included there. I recommend adding your treatment info to your signature line, like mine if you would like. It's easier than having to repeat yourself when asked during various conversations. You can find your signature section on your profile page and instructions. There are instructions on the Forum Info page (3rd box down). If you have any questions you need answered, don't hesitate to ask. Good luck!



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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247kath


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New here. On Clinical trial started 6/9/15 Harvoni and ribavirin for 12 weeks. 



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Treatment naive -Genotype 3a -no fibrosis. Found out in 90's that I had HCV. Started clinical trial June 9/15 Harvoni/ribavirin
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