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Hep C Discussion Forum -> On Treatment -> Steatosis and insulin resistance
Post Info TOPIC: Steatosis and insulin resistance
drummerman


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RE: Steatosis and insulin resistance
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yep, I had my IR tested several times during peg tx and even after for a while.

Got it under control for tx and was still a non-responder.  

 

oh well.

 

dm



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GT1Adiagnosed in 2007Interferon/riba2008non-responder7-25-2011 HCV RNA-10,783,000 7/6/15startedviekira/riba8/11/2015 - Week 5>15, 9/11/2015  "HCV not detected IU/mL. AST 16 ALT1110/16/16 - 2 weeks post EOT HCV NOT DETECTED AST18 ALT 14
drummerman


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"It seems that it is no longer a factor in these days of the DAA's."

Hope your right malani, cause I just don't want to adjust my diet. I like carbs waayyyy too much!

dm


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GT1Adiagnosed in 2007Interferon/riba2008non-responder7-25-2011 HCV RNA-10,783,000 7/6/15startedviekira/riba8/11/2015 - Week 5>15, 9/11/2015  "HCV not detected IU/mL. AST 16 ALT1110/16/16 - 2 weeks post EOT HCV NOT DETECTED AST18 ALT 14
mallani


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Hi Jack,

You're quite correct- there is little mention of IR in the latest research.

IR is very common in chronic HepC patients, with various studies reporting incidences of 30-75%. This is thought to be a direct effect by the virus on the Insulin signalling pathways. IR is associated with steatosis, particularly in Genotype 3, type 2 diabetes and induces fibrosis and causes an increased risk of HCC. In the old Interferon days, IR was associated with a decreased chance of SVR. All patients had a fasting Insulin and glucose done at my clinic.

It seems that it is no longer a factor in these days of the DAA's. However, I think all new patients should have a fasting Insulin done at some stage.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
drummerman


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I remember when I treated in 2008 there was a lot of discussion regarding steatosis and insulin resistance.  Many believed that these conditions made it more difficult to a achieve svr.

 

I'm not seeing anything about that now and am wondering if the way the new drugs work in such a different way that these conditions are no longer  considered a factor.

 

I ask, because I am IR and am wondering if I should address it.  I did bring it way down to normal when I was on peg/riba, ao I know how to do it (diet and exercise, ugh). 

 

I am not overweight, don't have steatosis, don't smoke , don't drink, not diabetic and in good health.

any thoughts, insights, etc. would be appreciated.

dm

 



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GT1Adiagnosed in 2007Interferon/riba2008non-responder7-25-2011 HCV RNA-10,783,000 7/6/15startedviekira/riba8/11/2015 - Week 5>15, 9/11/2015  "HCV not detected IU/mL. AST 16 ALT1110/16/16 - 2 weeks post EOT HCV NOT DETECTED AST18 ALT 14
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