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Hep C Discussion Forum -> On Treatment -> Harvoni & Libido
Post Info TOPIC: Harvoni & Libido
MikeH


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RE: Harvoni & Libido
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My tinnitus isn't severe, some might not even have noticed it at this level but it does seem to have gotten a bit louder. My ambition and energy seems to have diminished after initiating treatment. I was already experiencing ongoing fatigue that I attributed to the virus before Harvoni, and my impression of diminished libido may be related to this general sense of fatigue.

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61 yo, GT 1a, liver F1-F2 pre-treatment.

Diagnosis circa 2000. tx naive till 8/6/15, Harvoni tx initiated 8/6/15 through Gilead's Support Path. 28day labs: virus "und." Sides mild. EOT 10/28/15. EOT liver enzymes normal range: AST 25, ALT 18.
malekula man


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For tinnitus.. Possible, I don't really remember.

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G1b, stage 4, cirrhosis

Harvoni Tx: Jan-Jun 2015 for 24 wks, SVR12, SVR24

PrevTx : relapser, Sovaldi +Peg+Riba for 12 wks, Jun-Sep 2014

My thread
malekula man


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Really? I had only increasing... Normally virus affects the libido but with Harvoni in 3 weeks I had only positive experience...

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G1b, stage 4, cirrhosis

Harvoni Tx: Jan-Jun 2015 for 24 wks, SVR12, SVR24

PrevTx : relapser, Sovaldi +Peg+Riba for 12 wks, Jun-Sep 2014

My thread
Scruffy


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Hiya Mike

I more or less in my later years have tinnitus. I don't remember if the tx made it worse, it comes and goes. I think it got a little better after tx or I'm just used to the little "beeeeeeeep" I hear all the time. As far as the libido I was highly anemic on tx (not Harvoni) and had little desire. I did flirt with all my nurses but was aware if I became "ready" I would probably pass out from the distribution of blood. :)  It was better after tx. I celebrated by going grocery shopping in baggie sweat paints. Hot clerk "can I help you with somthing?" Me "well I don't know maybe"(insert pup tent here) smile.

Best wishes for you



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Geno 1a null responder 2004 inter/riba   finished incivek,peg/riba 48 weeks May 17th 2014. undetect weeks 4-12-32.  EOT+7 undetect. EOT+24 SVR!!!!! EOT+!YEAR SVR!!!!
MikeH


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Your old post came up in a search I did onsite before starting this thread mallani. I suppose it's possible some of the side effects "legacy" combination therapy patients experienced may apply to Harvoni users. Apparently tinnitus affects some in both camps. I'm interested to hear from others if they believe Harvoni (specifically) has had an effect on their libido, and if so, whether such effects resolved after the end of treatment. Temporary diminished libido doesn't seem like a big issue for me-assuming it hasn't been shown to persist after treatment.

No problem about the link Tig. I'm sorry to hear that you and others apparently have been left with persistent tinnitus.

 



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61 yo, GT 1a, liver F1-F2 pre-treatment.

Diagnosis circa 2000. tx naive till 8/6/15, Harvoni tx initiated 8/6/15 through Gilead's Support Path. 28day labs: virus "und." Sides mild. EOT 10/28/15. EOT liver enzymes normal range: AST 25, ALT 18.
mallani


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Here's an old post from me.

It may be relevant.

http://hepcfriends.activeboard.com/t53021482/sex-problems-and-hcv-including-treatment/



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Tig


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Hey Mike,

I don't know what happened there! I found one one thread when we discussed it and remember another, but can't locate it. I'll keep looking. Here's the most recent, sorry about the earlier goof.

http://hepcfriends.activeboard.com/t60707197/post-tx-labs/

 

KPB,

I also spent many years welding and working steel and running a maintenance and repair shop. Lots of the same loud noise you speak of. But that was nothing compared to the tinnitus I developed during treatment. I mean the stuff I've got now is obscenely loud and really limits my ability to hear. We have a lot of the old Interferon warriors and another one of the Victrelis users I talk to that also mentioned a terrible time with it during and after treatment. Unfortunately after two years of this, I'm afraid it's here to stay... Boo!



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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coolheat


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also developed tinnitus after starting Harvoni. Comes and goes. Mine sounds like crickets at night. Not a bad sound but gets old fast. I hear it now, but it could have been triggered again by Leon Russell on Fri. night. He's jam up and has a great lead.



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65 YO F, GT 1a1b, ast 14 alt 21, fibrosis 3/4 DX 1968 non a or b, TX 12 wks Harvoni, SOT 6.1.15, 1st bld wk: detected unquantifiable EOT 8.28.15 detected unquantifiable, 3 mo.EOT mid Nov.~SVR 12: ) UNDETECTED
MikeH


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Tig, thanks for the link, but it may be the wrong thread. That one seems to be about CoQ10 supplements.

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61 yo, GT 1a, liver F1-F2 pre-treatment.

Diagnosis circa 2000. tx naive till 8/6/15, Harvoni tx initiated 8/6/15 through Gilead's Support Path. 28day labs: virus "und." Sides mild. EOT 10/28/15. EOT liver enzymes normal range: AST 25, ALT 18.
MikeH


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I had moderate tolerable tinnitus before initiating Harvoni recently. I'm pretty sure it's increased since starting treatment. I was a pilot and cabinetmaker. Both are noisy occupations. I minimized my exposure with active noise-reduction headsets while flying and foam earplugs when operating loud tools but still developed mild tinnitus which may have been related to the working environments. Hammers can produce very loud impact noises and using them certainly caused my ears to ring temporarily. Your work probably could have caused tinnitus KPB.



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61 yo, GT 1a, liver F1-F2 pre-treatment.

Diagnosis circa 2000. tx naive till 8/6/15, Harvoni tx initiated 8/6/15 through Gilead's Support Path. 28day labs: virus "und." Sides mild. EOT 10/28/15. EOT liver enzymes normal range: AST 25, ALT 18.
KPB


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Tig,  I never took any of those drugs and I hear the same high pitched whining your talking about ALL THE TIME........  I have always just thought it was a side effect of the loud pounding of the steel that I worked on for 30 years



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VL - < 15 ,  LOG - < 1.18, @ 3 week blood test 

EOT 07-27-2015,  VL -   UND  ,   @ 9 week blood test  , 

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Tig


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Fem,

I'm convinced mine really worsened after starting Victrelis. I had minor issues beforehand, but a couple of weeks or so after starting Victrelis, I developed a new and very noticeable sound of rushing water. I went around the house looking for a running faucet. Then I'd go outside and check the hose, because I would lay in bed at night and it hear it so plainly and loudly that I was convinced it had to be water running. Then the high pitched whining started and has never gone away. I can hear it screaming right now. It's worse at night. I've tried expensive hearing aids, talked to doctors and there's nothing they can do. I have one of those sound apps on my phone and iPad that helps mask it when I can't take it some nights. Mostly, I'm just getting used to it and turning my TV up louder than the noise!



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Femapples


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OMG! I'm so happy to have found someone who developed tinnitus after interferon and ribavirin!  I thought it may have diminished after current treatment with Viekira and Riba.  Sometimes it comes back full force but most of the time, it's just there, albeit less apparent.



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Hep C, viral load 26,000,000, monoclonal gammopathy of undetermined significance (kidney), glomerulonephritis (kidney). 1994: Interferon, 2005: Interferon & ribavirin, 4/1/ 2015: Viekira Pak & Ribaviron, 12 weeks EOT: virus UND
Tig


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Hi Mike,

We have a member here currently that has expressed a concern over his testosterone reduction over the course of his treatment. Makes me wonder if this may be something you're experiencing too. I wasn't on Harvoni, but treatment caused mine to really tank. It may be medication related or antiviral therapy in general. It's hard to say. My levels returned to normal following treatment. Unfortunately for me, I also developed severe tinnitus that has become part of life. I think mine was the result of the old Interferon/PI protocols though. Time will tell in your case, but I think you'll notice significant improvements following treatment. 

Here's the thread started by Steve and the discussion on testosterone if you would like to review it: http://hepcfriends.activeboard.com/t60707197/post-tx-labs/

 



-- Edited by Tig56 on Monday 17th of August 2015 02:58:33 AM

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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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MikeH


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Day 10 on Harvoni, and along with the tinnitus, I think I'm noticing a reduction in sex drive which may be related to the Harvoni. Though I'm not finding a great deal of posts about this online, it seems some others are experiencing this and posting about it. Some are female. Found one post which suggests this side effect could be transient. Hope the tinnitus will be too:

Oh how you remind me... Yes, I had a very similar experience up until about two months post Harvoni treatment. Now that it's been a little over three months post treatment, everything is so back to normal that every morning when I wake up, he's standing at attention and asks "what are we going to do today boss?"

Anyone else?

 



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61 yo, GT 1a, liver F1-F2 pre-treatment.

Diagnosis circa 2000. tx naive till 8/6/15, Harvoni tx initiated 8/6/15 through Gilead's Support Path. 28day labs: virus "und." Sides mild. EOT 10/28/15. EOT liver enzymes normal range: AST 25, ALT 18.
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