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Post Info TOPIC: New Third Gen Drugs Abbvie Trial- The journey so far...


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RE: New Third Gen Drugs Abbvie Trial- The journey so far...
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Alrighty! It's now Day 4.

The one really weird, noticeable side effect for me is that I am incredibly thirsty! I am one of those people that rarely drinks any water...I knew and was prepared to up my intake during treatment but, what do you know? I HAVE to have a water bottle with me at all times, including at night, because this stuff makes my mouth, my throat, and sometimes even my sinuses really really dry otherwise.

Other than that, though, no trouble in paradise! I was told by someone who took the same stuff during a previous trial, to eat a fairly good meal 20 min prior to taking the pills- and that completely eliminated the stomach upset. I had a mild headache first couple days here and there, but it felt like a dry sinuses/hydration issue...it was not constant or very strong. I suspect it will not last.

That's it for now, folks. My lab visits are on Tuesdays. I will be posting results (and other things of interest) as they arise :)

Pin cushion pic made me smile! the nurse was sooo good though- 5 pricks, no bruising!

Thanks for being with me...don't wanna be lonely...

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38 yr old, Fib stage 1, last VL 5.3 mil - Cured by Abbvie clinical trial

Genotype 1a, Dx 2010 but probably had for 20 yrs+ 



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Hey Alexandra

Great picture, brings back good memories of when I went through the exact same protocol with my Abbvie trial. Its a very exciting time knowing that the Hep-C life cycle is being stopped within your blood and organs. Your going to do very well with the trial, these new drugs are excellent in everyway. I agree, its a big hassle to have to have blood draws but it keeps you really up to date with your progess.

Thank you for keeping us in the loop as we are keen on trials here at the forum.

matt    



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 

Tig


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Hi Alexandra,

Congratulations on your start of treatment! I'm very interested in how you progress and would really appreciate it if you keep us updated on everything as you go forward. You are our first on this protocol/trial that I'm aware of and what you can share will be very helpful to those that follow in your tracks. I have also read the articles and reports that indicate this is another blockbuster in the making. You're going to beat this thing and we'll be right here as you make your way through it.

I called your laboratory today to give them a talking to about sticking you with so many needles. They said as soon as they were done, you headed for the doorway like a shot! They did mention they got a picture of you as you were heading out and I thought I'd share it with everyone here. I hope your sense of humor is good, lol! I hope you're feeling better soon. If you need anything, just let us know smile

 



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Congratulations Alexandra on getting started.  Looking forward to seeing your improved lab results and the first UND. :)   Hopefully you'll get through tx without too many side effects.  Looking forward to the big SVR:)



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.



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Hi Alexandra,

I`m really pleased to see you`ve started this trial, and you should do very well going by the data we`ve seen so far.

You had quite a day with so many blood samples taken!  I should imagine the queasiness will ease off as your system adjusts to the drugs, let`s hope so anyway.  The stress of the long day mixed with apprehension probably didn`t help. 

Please do keep us posted on your progress, and thanks for sharing your trial journey with us.

Wishing you the best of luck! 

 



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Jill 

(69 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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This is for the new stuff, nicknamed ABT 493 and ABT- 530 for now. I have found one more person so far (on facebook) who participated- I am hoping there are others, or soon will be, as the Phase 3 trials are currently under way. We could compare experiences and share information...

Today was my first day. I will add to this as I go along.

It was a rough first day. There were a total of 5 needle pricks, signifying blood samples (many, many tubes) taken at 2 hrs intervals from 8 am to 2pm. I had to wake at 6am, no coffee (fasting required)...harsh. But this only happens twice during the trial. The rest of the visits (at weeks 1, 2, 4, and 8; and then post treatment at 2, 4, 8 and 12 and 24 weeks) only require one blood test, a weight in and urine sample and a short chat.

I am in the 8-weeks treatment arm of the trial, being compared to a 12-week treatment arm... I would have preferred the longer treatment, but I was told the chances of success are still excellent, even so. With little to no side effects.

However- I was very, very queasy all day. Maybe it will go away?



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38 yr old, Fib stage 1, last VL 5.3 mil - Cured by Abbvie clinical trial

Genotype 1a, Dx 2010 but probably had for 20 yrs+ 

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