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Post Info TOPIC: Post tx 3 mo. VL test


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RE: Post tx 3 mo. VL test
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Congratulations Gypsy Soul!  Seems like this train may never stop for maintenance. With all the Undetected's and SVR's, maybe now it's time we invest in one big ol' Cruise Ship. WOW...what a year to be alive.

Happy Thanksgiving to all. And please......EAT TOOOOO MUCH!!!   biggrin



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60 yrs. Geno1b 2001. 9mil. VL. �Failed Post Riba/Peg tx. 2006 46 weeks. Diagnosed 1A 2015(?) F3 fibr. 225k VL. Vikera/Riba 12 weeks 3/20/2015. "Undetected" start to finish. Undetected 1yr post tx.



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Thanks Tig!!!!!!

WOWWWWWW!!!! That sure is some encouraging news biggrin



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 57 yo..Tx naive...Gen 3.. SOT 24 weeks Riba/Sovaldi...  June 20, 2015..VL 1,200,410. AST 73, ATL 85,

Fibrospect F-0, F-1

 

Kathy

 

'What if I fall?" "Oh but darling...what if you fly??"



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Marsha, After that ordeal you went through , I don"t know how you kept it together so well? Your one in a million!  I"m so happy for  you.  RC



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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   

Tig


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Hi Gypsy,

Yes, the report stated that almost 80% (78) of relapses occurred during the first 4 weeks following EOT. Concordance between SVR 4, 12 and 24:

"In a retrospective analysis of data from five phase III trials of sofosbuvir-containing regimens (with and without peginterferon) in 863 patients with HCV infection (genotypes, 1?6), investigators assessed the concordance between SVR at 4 weeks (SVR4) and SVR12, concordance between SVR12 and SVR24, and positive-predictive and negative-predictive values (PPV and NPV).

The concordance of SVR4 and SVR12 was 98% (PPV, 98%; NPV, 100%). The concordance of SVR12 and SVR24 was >99% (PPV, >99%; NPV, 100%). Over three fourths (78%) of patients who relapsed post-therapy did so within the first 4 weeks."



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 8+ years!

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Congratulations!!!!!!

I will finish Tx Dec 4th......WOO-HOO!! I have been undetected since week 2.

My EOT lab will be Dec 8th...so I asked when the next lab would be after that.....

and she said they will do an EOT 4. If that is still undetected...more than likely that if

you relapse it will be in that time period. Sound right??????



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 57 yo..Tx naive...Gen 3.. SOT 24 weeks Riba/Sovaldi...  June 20, 2015..VL 1,200,410. AST 73, ATL 85,

Fibrospect F-0, F-1

 

Kathy

 

'What if I fall?" "Oh but darling...what if you fly??"

Tig


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You're correct. Once SVR4 is achieved, the likelihood of SVR12 is almost equal. They haven't established SVR4 as the standard, because the relapses that have been recorded, tend to occur within that 12 week post treatment period. Used to be EOT+24, then +12 became the standard for SVR. With the similarity we're seeing between the rates of SVR4 and 12, that may be the next determining timeline in the future. In the meantime, the probability should give people a lot of hope and encouragement. Right now though, getting your providers to do the test at EOT week +4 has been met with some resistance because the standard remains the week 12 viral load.



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 8+ years!

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Reading the report (http://hepatitiscnewdrugs.blogspot.com/2015/01/sofosbuvir-based-regimens-for-hcv-svr12.html) it seems that SRV 4 should be almost the same at predicting a cure as SRV12. 

 

So happy to hear about your success. 



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58, GT2, Peg/Riba 2010 failed, SOT Sept 2015 to Dec 2015 on Sovaldi/Riba, SVR-EOT, SVR4, SVR12!!!!!!!!! CURED!!!!!!



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You made my day Marsha! Awesome result and I am so very very happy for you...SVR!



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60 yo (2013), genotype 2b, started 28 week tx Sept.14, 2013. Triple Therapy (ribavirin, victrelis, peginterferon), VL 235k prior to tx, UND right through. EOT March 29, 2014. EOT24 Sept. 15, 2014 and EOT + ONE YEAR April 1, 2015 UND.... SVR!

 



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Hey, thanks again. What a relief.  Mentally I have been feeling a lot better. I have been telling friend and family that I feel "happy" and that I feel "more Love".  In my mind I was thinking, "bet the virus is gone".  Have felt so relaxed and like my body doesn't want to jump out of itself.  Feel like I have more to give back than at any other time in my life. We are so fortunate to have lived long enough for this cure. Bless those who suffered and moved on.  I thank all of you for your support. And yes, wmlj1960, it did feel like Dr. Frankenstein.  Have names to choose from for excellent Dr.s with excellent recommendations.  Hope everyone has a Lovely Day of Thanksgiving for all we have and our opportunity to live in the United States. The young people of today remind of ourselves in there wisdom and determination to make the world a better place to live. WE are all Blessed.

Grouper, we could go on a charter boat out under the Gate and go north a bit, big kings and reefs with black, red, and rock cod.  Matt, went through the tunnel to the other side on an od in 69, never had felt such unconditional love and forgiveness for all. At first was a bit miffed that I came back.  Glad I came back now. Marsha



-- Edited by coolheat on Sunday 22nd of November 2015 08:38:01 PM

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65 YO F, GT 1a1b, ast 14 alt 21, fibrosis 3/4 DX 1968 non a or b, TX 12 wks Harvoni, SOT 6.1.15, 1st bld wk: detected unquantifiable EOT 8.28.15 detected unquantifiable, 3 mo.EOT mid Nov.~SVR 12: ) UNDETECTED



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Nice Marsha!!

Congratz... I kinda thought you were gonna be clear on your next test. Big day for you. Time for a happy dance!!!!



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Geno 1a null responder 2004 inter/riba   finished incivek,peg/riba 48 weeks May 17th 2014. undetect weeks 4-12-32.  EOT+7 undetect. EOT+24 SVR!!!!! EOT+!YEAR SVR!!!!

Tig


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Hi Marsha,

SVR12 is the new standard! Congratulations again!!!  smile

 

http://hepatitiscnewdrugs.blogspot.com/2015/01/sofosbuvir-based-regimens-for-hcv-svr12.html



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 8+ years!

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I'm so happy for you...I felt so bad with what you were going through and have been waiting for this good news. What an incredible sigh of relief you must have breathed when you got the news! Congratulations. Although the gold standard is still 24 weeks EOT...with Harvoni there is something like only .03% difference between 12 and 24 weeks so relax...it's pretty much the same.

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64 year old EOT 10-28-15,SVR24 April 21 2016  ALT-12/AST-23 June '19 - fibroscan 6.9 F-0 July '19



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Hey Thanks Everyone!  You held me up when I felt so down. I really appreciate the Whoots.  Will keep you posted on the blood results, should get them first of week. Tig, is SVR at 12 weeks?  Is the gold standard still 6 months? Thank You, Marsha



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65 YO F, GT 1a1b, ast 14 alt 21, fibrosis 3/4 DX 1968 non a or b, TX 12 wks Harvoni, SOT 6.1.15, 1st bld wk: detected unquantifiable EOT 8.28.15 detected unquantifiable, 3 mo.EOT mid Nov.~SVR 12: ) UNDETECTED



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This is absolutely awesome, all the crap you went through with Dr Frankenstein and being told you failed treatment and now this. What a marvelous end to such an emotionally traumatizing ride. I am so happy for you Marsha. Well done with hanging in there like a true warrior! Enjoy your Hep C free life to the fullest! Party Time!!!    



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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SVR!   That's what I'm talkin bout, think I'll get out of bed and do a happy dance for you Marsha.  Maybe love on my dog some too.  Great news, I think your doc was a quack, quack. :)   Yes I have a big ole seg on my face:)



-- Edited by Groupergetter on Saturday 21st of November 2015 03:38:17 AM

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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.



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Marsha

Simply AMAZING ! , You must feel like you have been resurrected.

I can feel the joy through the spirit of the air, super congrats well deserved

matt  



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 

Tig


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You know what EOT+12 and undetected mean, right? It means:

image.jpg



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 8+ years!

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So, it's really more than undetected, it's also SVR 12, right?  What a strange way to get there!  What a blessing, however you got there.  



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65;  Dx 1997 1a; VL 1.1m; TX naïve; SOT 7/20/15; 12 wks viek/riba 1200mg

09/14/15 draw: Undetected 8 wks into tx

10/12/15 draw: Undetected at EOT

01/05/16 draw: Undetected at E0T+12

Tig


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WOW, WOW, WOW!!!!  This is the best news I could've hoped to hear from you Marsha. I had that feeling the entire time, that your EOT results weren't the end of the road for you. Your results just kept me on the high side of confidence and my gut feeling was right. I don't think I could be any happier than I am right now! Congratulations my friend, if you're flying any higher than I am right now, you better hang on!! This is great!!

                                                  WOOT!         



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 8+ years!

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Marsha,

I am sooo happy for you!!!  WOO HOO!!  It is PARTY TIME and I'm dusting off my DANCING SHOES! 

                                                             

Penny



-- Edited by Penelope PePod on Saturday 21st of November 2015 03:07:12 AM

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65;  Dx 1997 1a; VL 1.1m; TX naïve; SOT 7/20/15; 12 wks viek/riba 1200mg

09/14/15 draw: Undetected 8 wks into tx

10/12/15 draw: Undetected at EOT

01/05/16 draw: Undetected at E0T+12



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WOOOOOOOOOOOOOO HOOOOOOOOOOO, YOU MADE IT  *=D> applause   So happy for you.  It's a GREAT day   Enjoy your hepC  free life. 



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.



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                  UNDETECTED



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65 YO F, GT 1a1b, ast 14 alt 21, fibrosis 3/4 DX 1968 non a or b, TX 12 wks Harvoni, SOT 6.1.15, 1st bld wk: detected unquantifiable EOT 8.28.15 detected unquantifiable, 3 mo.EOT mid Nov.~SVR 12: ) UNDETECTED

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