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Hep C Discussion Forum -> On Treatment -> TK's Solvaldi/Velpatasvir 12 week Dragon Slaying Adventure!
Post Info TOPIC: TK's Solvaldi/Velpatasvir 12 week Dragon Slaying Adventure!
Zlikster


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RE: TK's Solvaldi/Velpatasvir 12 week Dragon Slaying Adventure!
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Great results TK,

depending on the lab's type RT PCR LLOQ treshold (eg. in my hosptial it's Abbot with 12 IU/ml LLOQ), thats barely detectable. W4 will be UND i am 100% sure ;)

and baby liver smooth ALT and AST too ;)



__________________

GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
tkflex36


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2 weeks results are in.

Alt-19

Ast-21

VL- <15 detected 

So I guess the only way it gets better is <15 undetected?

I'm not really sure what the difference is between the two? Anyone?



__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
Shadowfax


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This sounds great TK. 

Three weeks already and feeling good. This is the news we so much like to hear along with good Lab work.

You got this!



__________________

65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *
Linuxter


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Hi TK,

WoW, you are flyin' through this Tx ... congrats on 3 wks!

Keep us posted on the Labs ... best of luck on 'em.

 

Dave



__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
Tig


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You're really moving now Rich! We're all eager to see your upcoming results. If you get tired of those 5 hours of sleep at night, send em my way, lol! Good luck, half way is on the way!!!



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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tkflex36


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Day 21 today! 25% of treatment is done and besides only getting about 5 hrs of sleep a night, I feel fine. I'll post up my 2 week blood work as soon as I get it (probably Thursday). I hope everyone is doing well!

 

TK 



__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
Cinnamon Girl


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Amazing result so soon, Rich, I bet you haven`t stopped smiling yet!

You have good reason to be happy with how it`s going so far, this is powerful stuff!  Congrats!  smile



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
malekula man


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Congrats man!

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G1b, stage 4, cirrhosis

Harvoni Tx: Jan-Jun 2015 for 24 wks, SVR12, SVR24

PrevTx : relapser, Sovaldi +Peg+Riba for 12 wks, Jun-Sep 2014

My thread
tkflex36


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Thanks for the kind words everyone! It feels really good to have normal liver levels for the first time in more then 15 years. And since I was under 15 after 7 days and today was day 16 I'm probably already totally undetected. I had my 2 week blood work done yesterday so next week I'll have those results. Then I'll have week 4 test, week8, week 12, then 12 weeks post tx and 24 weeks post. I truly believe gilead hit a home run with the velpatasvir! I can't feel the dragon taking its last breath!



__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
Matt Chris


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Hey Rich

Great to read of your first lab tests, your VL is right where is should be (so low that it can hardly be detected) your going to do just fine.

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Zlikster


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great news! Seems Velpatasvir is indeed Gilead's Daclatasvir killer (poor BMS) :)



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Tig


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Hey Rich,

Wow! That's incredible! I think you fell into your own pot of gold, outstanding news. Let us know when you hear the rest. The ALT/AST are superb. Can you feel that big old smile coming from that happy liver? Or maybe it's the frown of a soon to be defeated Dragon. Congrats on the great news! smile



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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tkflex36


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Don't know why the rest didn't post but the results were hcv rna

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36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
tkflex36


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Got vl test results back after 7 pills of the sof/vel! Hcv rna is >15 detected!

Ast-22

Alt-17

-- Edited by tkflex36 on Thursday 21st of January 2016 01:09:34 PM



-- Edited by tkflex36 on Thursday 21st of January 2016 01:20:16 PM

__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
Bills


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Wow this does sound exciting Super Harvoni and Bullet Train, I know I bitched at Gilead a lot. But I am grateful to be cured. With all this new stuff coming out maybe the prices will have to come down. Anybody know if they are coming down? If this is more expensive than Harvoni? Will insurance cover it the same way? Something to think about?

Best of luck TK if Wasn't cured I'd be right there with you  Be safe and be cured

BillS

Going back down here I see it is  a Gilead drug  Hmmm forget what i said about the price things  lol

Super Harvoni sounds great  best of luck TK

 



-- Edited by Bills on Tuesday 19th of January 2016 11:31:43 PM



-- Edited by Bills on Tuesday 19th of January 2016 11:51:15 PM

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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.

Linuxter


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Best of luck on those results TK, I get the feeling that this whole trial is going to be nothing but Great news for you.

I believe you're on the Bullet Train ... biggrin

 

Be Well,

Dave



__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
Zlikster


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that explains :)



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
tkflex36


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No that was from 2 weeks before tx and the day I started tx. I'll know the results of after one week of tx tomorrow!



__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
Zlikster


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Hi TK,

so your base ALT was 59 and @ w1 it was 52? I have expected more from w1 to be honest, but lets wait w4 results.

thanks for updates, very very excited on the Sof/Vel combo, i think you will do great. No sx, smooth ride ;)

best



__________________

GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
tkflex36


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Hi Everyone,

Well today is day 14 on the sof/vel. And I'm very happy to report thst I still have absolutely zero side effects! I realize it doesn't make for very good updates but I'm sure some people may get some comfort from knowing sides are not always an automatic thing with these meds. I go in for my 2 week blood work tomorrow at 11am. I'm really hoping my 1 week vl test is back, but they did mention it takes like 5 business days for the vl test results. 14 hour work day today for me, hope you all have a great day!

TK 



__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
tkflex36


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One week blood work taken yesterday. My vl wasn't back yet from the day I started but my lft was. My starting alt was 59 and ast was 52 so pretty good. I can't wait to get the week one vl test results back.



__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
Tig


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Hey Rich,

I'll clean up the Dremel and diamond bits and warm up the Lear jet. Let me know when you've had enough of that tooth! 

Sounds like everything is going the best way possible, keep it up! I'm curious to know your results too, so keep us up to date. Good luck and enjoy your time as the Energizer Bunny!



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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robertsamx


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Rich, Looks like  you pulled a good arm on the trial.  24 weeks will get the job done. At week 10 in my last trial I had a molar/filling fall apart. With just two weeks to go I dident want to rock the boat, so I kept it to myself. Yesterday I spent 2 hrs in the Dentist chair having a crown build up and a temp installed. Had that happened early in treatment I would have reported it to the study and they would have OK"d antibiotics .  It was just so close to the end of treatment,it did not hurt,so I decited to get it done at the end of treatment.

Glade your feeling well, and able to work. Daily noon atom bombs going off ! That sounds good!  Keep up the good work.  RC



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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
Zlikster


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keep us posted! :) When is your first PCR due? w1 or w2? Can't wait for some data to see how Sof+Vel goes vs Sof+Dac :) exciting!

best



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
tkflex36


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Hey everyone!

It's day 7 and all is well. I go for one week blood work tomorrow and will get my exact results form 12/21 and 1/6 the day I started tx. Tig I'm thinking that diamond bit dremmel might be exactly what I need..lol I started a new job like 3 days after I started tx, been working 10 hour days with energy to spare, I'm really hoping things stay going this good!

 

TK



__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
Tig


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Hey Rich,

How's that tooth? Hang in there bro, sounds like you're on the smooth road to success. Aside from that damn tooth, you're doing great! 

 

PS: I've got a hammer, chisel and pliers if you need help with that tooth. Oh, I also have a Dremel with diamond bits, we could have you fixed up in no time, lol! We have pulled the teeth out of a few Dragons around here, so you'll be well taken care of, promise! biggrin



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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malekula man


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That's great news! Good chance! Kill it!
12 weeks on it will be just a flash in your life.

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G1b, stage 4, cirrhosis

Harvoni Tx: Jan-Jun 2015 for 24 wks, SVR12, SVR24

PrevTx : relapser, Sovaldi +Peg+Riba for 12 wks, Jun-Sep 2014

My thread
Linuxter


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Sounds good Tk,

Hhope you got the tooth problem(s) all fixed, I recently went through a whole round of tooth problems but got everything worked on and am back in service now.

Glad to hear that there are virtually no side effects so far with this Tx, that's a big plus!

Thanks for keeping us posted. May you experience smooth sailing the whole journey.

 

Linux

 



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
tkflex36


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Day 5 So five days in and can honestly say I have had zero sides I can attribute to the meds. If there were a placebo arm in this trial I would think I was in it. Can't really notice any positives either except maybe a bit more energy and focus. I go in for 1 week labs on wed. Hope everyone has a great upcoming week!

__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
tkflex36


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I started on augmentin. Trial said that's ok too. Tooth developed an abscess so I'll be getting that taken care of asap!

__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
dragonfly


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Hi, I've taken Amoxicillin on every treatment I've been on - it's fine.  Good luck. 

Nirmalee



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Tig


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Hey Rich,

I feel for ya brother! I think it was about week 4 that I had a tooth split in two under a crown and the nerve was comprimised. I was dying from pain. I saw an oral surgeon because my dentist was afraid that my low white count and platelets would cause trouble for both of us. I was on the old stuff and it made a difference then. But my hepatologist said that it was fine, gave the oral surgeon the okay to start me on Amoxicillin and pulled the tooth. I had no problems at all and it had zero affect on my treatment. Just make sure you start eating yogurt while on those antibiotics, your digestive tract will thank you for that! Good luck buddy or should I say "Toothy"? smile



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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tkflex36


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Hey everyone! Today's day 3 and I don't have much to report in the way of sides or anything. I do look forward to noon each day to take the pill, I feel like I'm dropping an atomic bomb on the virus every time I swallow one..lol. Question for people who have been there. I think I may have an infection in one of my teeth causing much pain and swelling. I need to go to a dentist but was afraid to go on an antibiotic while on treatment. I emailed the trial coordinator and she said antibiotics were ok besides clrithromizan, (sp) and enythromizian. Anyone else had to take say amoxicillin while on treatment?

__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
wmlj1960


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Awesome! We have another trailblazer on our team. I'll also be glued to this thread to witness how well "Super Harvoni" takes you into the "land of the dead dragons". Good luck Rich!



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Tig


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Outstanding Rich! We'll be following you closely, so lets keep this thread active. I'm sure a lot of people will be interested in your progress. This is a pan genotypic protocol, as you mentioned and is supposed to be quite effective. All signs are pointing toward SVR buddy, good luck!!



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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tkflex36


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Daclatasvir killer lol. My doctor did refer to velpatasvir as "super harvoni" today! And Linux, yes this is a pan genotypic drug, and I will be getting almost weekly blood work so everyone will have a really good idea how this stuff works.

__________________

36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
Linuxter


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Hey Tk,

If I'm not mistaken, sof/vel is what may soon be marketed for across the board genotype cure (non-genotype specific).

If so, that should be a definite dragon killer.

Re: fibrosure test I'm guessing you mean .029, which is very good, you'll be killing the beast before it even leaves a bad scar on you.

Just think, in 24 weeks you can officially achieve SVR ... right on!

Your documentation will help others down the road, wishing you the very best of luck my friend.

 

Be Well,

Linux

Edit: Ya "pan genotypic" ... what he said ... blankstare.gif ... lol.



-- Edited by Linuxter on Wednesday 6th of January 2016 11:59:05 PM

__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
Zlikster


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:) great man, let us know how it goes. There are huge expectations for Velpatasvir as Gilead's "Daclatasvir killer".

best

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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
tkflex36


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So this is it, I was randomized to the 12 week arm of sof/vel and took my first dragon bomb at 12 noon today. I'll update my most recent bloods in my sig later, but my fibrosure test done 2 weeks ago was a .29 or F1, and VL was 509,000. I got caught up in the moment and forgot to ask my lft results, but I go back next week so I'll be sure to get them. This thread will serve as my tx log including sides, updated tests, etc. I really look forward to the world of SVR and the land of the dead dragons!



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36 yo M, first dia in 2002, geno 3A, TX naive, starting trial of sof/vel 12 weeks on 1/6/2016

VL on 12/21/15- 507,000

12 week EOT 3/30/16, VL-UNDETECTED ALT-23, AST-24

24 wk post tx  10/16 VL-UNDETECTED! ALT-16, AST-18

SVR24+all LFTs normal=1 DEAD Dragon!

 

Don't stop fighting til the dragon is DEAD!
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Hep C Discussion Forum -> On Treatment -> TK's Solvaldi/Velpatasvir 12 week Dragon Slaying Adventure!
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