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Hep C Discussion Forum -> General Discussion -> Let's find out what's really happening!
Post Info TOPIC: Let's find out what's really happening!
Mike


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RE: Let's find out what's really happening!
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Hi Malcolm,

Congratulations.  Me and the mrs. are so very happy for you. biggrin



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1-18-16 referred to gastroenterologist;  AST 191 ALT 246, Viral Load 1,976,000, Alpha Feto Protein/Negative for Cirrhosis. Genotype 1 a. Tx began 3/9/16 Harvoni, 8-12 weeks

 
Cinnamon Girl


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These results will certainly be very interesting for a lot of us here, Malcolm, and I can understand why you want to have the biopsies and further tests done.

Thanks as always for sharing so much helpful and interesting information, we`re so lucky to have you with us! 

I wish you the very best of luck, you certainly deserve it!!  smile

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Michaele


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Good Health Malcom , Best wishes with your test.    Michaele



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MDodrow
Greg D


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All the best Malcolm! Like others here I too wish a healthier liver for you. Hopefully the results will be most favorable and least confusing. Thank you for doing this!!



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60 yo (2013), genotype 2b, started 28 week tx Sept.14, 2013. Triple Therapy (ribavirin, victrelis, peginterferon), VL 235k prior to tx, UND right through. EOT March 29, 2014. EOT24 Sept. 15, 2014 and EOT + ONE YEAR April 1, 2015 UND.... SVR!

 
dharmabum


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Hi Malcolm,

Hope you have a good result and do not feel the pokes; you deserve a pass here.  

Show that liver who is boss and best of luck.

 



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Joann

 

Geno 1a  - failed Tx Inc/Int/Rib - Tx Harvoni 1/14/15 - UND at EOT 4/7/15, 7/7/15, 9/9/15, 12/04/15, 10/26/16
Bills


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Hi Malcom,

The very best of luck and great results. Thanks for sharing all your wisdom and experience here. This will become a real interesting topic. Doctors and reports and publications can only tell us what they want to say at the time. I very hard to understand.  You been here in the trenches with us this journey would not be the same without you and all the other gurus here We're praying most of all for you to have good news and a healthier liver

 

BillS  



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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.

mallani


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Thanks for the interest, guys.

Tig: My Lab doesn't do FibroTest (FibroSure) any more. They have offered me an ELF (Enhanced Liver Fibrosis) Test (link to my Lab.)

http://www.snp.com.au/media/370775/enhanced_liver_fibrosis_score_elf_score.pdf

This is fairly new, and uses an algorithm of serum markers. If you're interested, these are Hyaluronic Acid (HA), the amino-terminal propeptide of type 3 pro-collagen (PIIINP), tissue inhibitor of metallo-proteinase-1 (TIMP-1) and age. Sorry.  It may be interesting to see where it fits in.

Matt: I hope to have 4 biopsies- liver segments 5,6,7 and 8, with 2 cores from each site. I have access to my pathology slides from 1998, and these will be compared. The histological changes are usually the same in the R and L liver lobes. The caudate lobe may be less affected, but that's impossible to biopsy.

I'll be having an MRI after the biopsy to check for bleeding, and luckily the machine at Greenslopes Hospital can do MT Elastography. I now expect to be confused.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Linuxter


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Fingers and Toes crossed Malcom ... another vote for F2-3 A0-1 ... very good luck to you!!

 

Wishing you well,

Linux



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
Tig


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Since you'll be there, why not have them draw a Fibro Test (Sure)? That would be a very interesting comparison. 



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Matt Chris


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Hey Malcolm

Wow! Sounds like a science experiment by a doctor. LOL Not surprised with your inquiring mind. Maybe you should nave been a HCV researcher, of course you have been been for over 25 years.

I would guess if your biopsy location is the same area as a single Fibroscan that should tell the tale, but won't the different lobes of the liver will have different amount of cirrhosis? I thought that some lobes have more or less scaring.

Hey while your there ask your Hepatologist about NO / Nitric oxide in liver disease. Been reading about if increasing NO in body, would be friendly to a cirrhotic liver or foe?

matt   

     



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Gracie


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YES! Really glad you are doing this. They really should be following up with SVRs to track improvement. And doing both Fibroscan and biopsy is ideal to figure this crap out. THANK YOU. THANK YOU Malcolm, you rock!



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  1. Gracie

1A. Previously treated non responder Rebetron in 2000 And Incevik in 2014 with a breakthrough at week 12. Fibroscan 15.5. VL 6,000,000. Finished 24 weeks harvoni on Dec. 19, 2015. SVR. Latest Fibroscan 8.8.
Jaded


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Good luck Malcolm...hoping to hear of good news for you.

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64 year old EOT 10-28-15,SVR24 April 21 2016  ALT-12/AST-23 June '19 - fibroscan 6.9 F-0 July '19
bubble


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Get on those avacado's Malcolm and good luck to you! I know your results will astound us all.



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60 yrs. Geno1b 2001. 9mil. VL. �Failed Post Riba/Peg tx. 2006 46 weeks. Diagnosed 1A 2015(?) F3 fibr. 225k VL. Vikera/Riba 12 weeks 3/20/2015. "Undetected" start to finish. Undetected 1yr post tx.
Zlikster


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Keeping fingers crossed! Lets put goal to F2-F3 A0-A1 a? :) You sure there is need for biosy besdie Fibroscan+Fibrotest? I mean, i do not have anything against liver poking, but maybe it's time to perm move to non invasive tech at this stage?

cheers!



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
JimmyK


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Good morning Malcom.

 

The help and knowledge you have been willing to share here can only come from a kind and gentle soul. Your outcome is in the hands of God and to Him I pray all will be as or better than hoped for.

Much Respect!

 

JimmyK

 



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
wendyo


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Keeping you in my thoughts and prayers for smooth sailing



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 
robertsamx


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Malcom, your a pioneer ! Thanks for sharing everything with us. Looking forward to your results.  RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
wmlj1960


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 Wow, that will give you peace of mind and also be very educational to us all about regression. I hope the results do show F3-4 with A0-1 or better. That would sure make me happy and I know it will you. Good luck Malcolm! smile



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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Tig


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It will be interesting to see where you stand after 4 years. I appreciate that you're willing to share your information. This will be a good comparison of Fibroscan versus Biopsy. I know you'll come away with some interesting news.  Good luck Malcolm, I'll keep my fingers crossed for some significant regression! 



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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mallani


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Hi all,

My Hepatologist starts long-service leave on 15th February, so I have convinced him to do my liver biopsy next week. I'll be EOT+4 years. He's also agreed to a repeat FibroScan the day before. Hopefully this will will shed some light on this mystical subject. I'm hoping for F3-4 with A0-1. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
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