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Hep C Discussion Forum -> New Members Area -> Enrolled in Sofosbuvir/Velpatasvir/GS-9857 clinical trial
Post Info TOPIC: Enrolled in Sofosbuvir/Velpatasvir/GS-9857 clinical trial
Hoodietree


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RE: Enrolled in Sofosbuvir/Velpatasvir/GS-9857 clinical trial
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Didnt notice that thank you Tig! Guess I wont start tapping my foot waiting. 



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 
Tig


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Hoodie,

FYI: Michael (Webtomass) hasn’t been active in two years. He may not get your message.



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Hoodietree


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webtomass wrote:

BCAAA aminos powder 3 times a day

NALT once a day.

Matt, can you go into more detail about these two please? Im not familiar. 

Also have you (or anyone) tried Acetyl L-carnitine + Alpha Lipoic Acid for fatigue and brain fog? I found that helpful pre-treatment and I miss it a lot right now at 4 weeks on treatment. 

I understood BCAAs were for muscle repair and never heard of supplementing with that outside of a fitness/weight lifting protocol.

Never hear of NALT is that naltrexone?! Anyone tried that at low doses?! Ive heard its good for folks like us but hard to get your hands on.

Would love to hear more. Many thanks in advance. 



-- Edited by Hoodietree on Sunday 26th of August 2018 02:02:22 PM

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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 
Tig


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Hi Mak,

If you read his signature, he mentions he was a genotype 4, which is a less common genotype and found more often in the African continent and some southwest Asian areas. He completed Vosevi treatment successfully, in April of 2016. 



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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mcmaklin


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Have you been treated Webtomas? And what genotype ?



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND
Canuck


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Hi WTM,

Great you're finished, and great you were UND at WEEK 8, and now, are just waiting for your (12 week) EOT VL.

I agree, I too think vel will prove to be a real winner. Thank you for keeping us posted.

I am waiting for my WEEK 4 VL drawn April 7 - I will also post this as soon as I know it. smile C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
Tig


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Congrats WTM!! EOT and already having that kind of energy is an excellent indication of a quick recovery. That's quite a supplement plan you've got going! Good luck and do keep in touch regarding your post treatment labs. 



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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webtomass


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forgot... on top of a weekly B-12 shot take 1000mcg sublingual B12 everyday and Folic Acid. Add a B Complex if you can. Nutrients adequately taken solve many health issues. 



__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
webtomass


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B-12 injection once a week

BCAAA aminos powder 3 times a day

NALT once a day.

Exercise and replenish calories when you burn them.

There are other things I take but the above is what is helping.

 

Cheers, M



__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
webtomass


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Hi Matt,

Completed treatment and will get blood results end of next week. No sides this is a breeze nurse told me not same for some who will have side effects but nothing major.What I'm really interested in is 3 months from now. Same as you Matt, at week 12 post treatment it came back on Vpak +Rib treatment. But from my calculation considering how low my liver panel reading got right away after 2 weeks, I have a good feeling I'll stay SVR. ITs interesting you reached SVr with Harvoni alone after your first treatment.

As for physical activities is concerned, well let me tell you I put lots of mileage on this body and no problem getting the blood to extremities of my body. I blade 18K under 1 hour. 2 days on 1 day off on and on. I also take lots of BCAA and NALT. That also helped getting oxygen to entire body and muscles. 

I will post my EOT result when it comes in. I think this is really the treatment  that will be taken by all very soon. As far as I'm concerned the debate is over. Gilled is the winner. 

Cheers, M



__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
Matt Chris


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Hello Webtomass

Congrats on achieving UND, stay physically active as you can during the last of your treatment with the goal of moving your blood to the deep recesses of your body.

I also relapsed during the Abbvie Clinical trial for Vieira Pak + Ribavirin treatment, but reached SVR with Gileads "Harvoni"

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
wmlj1960


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 HEY!, I want to know your secret for getting those platelets to improve every time. I need some of what you've got Webtomass. What ever you're doing, keep doing it!



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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RAGDOLL


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Excellent News! You are doing great.  Have a great week-end.  CC



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F 63,  1b  1974, no cirrhosis, fibro scan 5.8 F0-F1,fibro test .37 ,V/L 702987, ALT 90, AST 75.  ABBVIE Topaz II on 10-30-14 Viekira Pak no RIBA , EOT 1-22-15 SVR, ALT 37, AST 29, 4-15-15 SVR12 - fibro test .22,  1-21-16 SVR 52 ,  1-21-17 SVR 104! 1-21-18 SVR 3 years ,2020 5 years, 2022 7 years!
Cinnamon Girl


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Hi Webtomass, thanks for sharing your results so clearly, you`re obviously responding very well indeed.  Congrats on your 8 wk UND viral load!

You must have been so pleased to get into this trial after your previous tx with Vik Pak + riba didn`t work out, this is such a powerful and effective drug combo, and we`re very interested in following your progress.

Good luck, and keep us updated!  smile

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Canuck


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Congrats webtomass!

Must feel great to get that undetected!

So glad for you.

Too bad you could not have known your WEEK 2 and WEEK 4 VL's, as you probably could have been celebrating your undetected status even sooner than at WEEK 8! But very glad your sixth sense is "on" and that it is also telling you - "It's gone".

No noticeable sides at all? I notice minor gastric roiling and some headaches, maybe some increased fog - I wonder if it is from the GS-9857?. Who knows. But if they are sides, then they are a very small price and well tolerated. tkflex36 (SOF/VEL) 12 WEEKS said the same as you - no sides.

Very interesting to see your progress (yours, mine and tkflex36's) - so glad you updated us, and VERY pleased for you. 

Just waiting for robertamx to join this velpa party now!

Great news! Happy for you. smile C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
wendyo


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Looking good Web. NICE results. 



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 
Sydhanrahan


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How exciting Webtomass,

those bloods look awesome. It's very satisfying to hear that someone who's already been through the mill once, looks like finally reaching their destination. 

Now, just go and chillax in a recliner in the first class club over the other side of the tracks and your final bloods won't be too far away. 

Syd



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Contracted Hep C 1969. Genome Type 2, treatment naive. Began 12 week RIBA/sof/Dac on 12/11/15. Cirrhosis. VL before treatment 4m. Treatment extended another 12 weeks without Riba. No virus detected at 9 weeks.
robertsamx


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Hi Web... Your in a good spot at 8 weeks. The LFT's look good especially the UND!!  And to think you have 4 more weeks of treatment drugs to go! Now your throwing knock out punches.   Keep swinging!   RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
webtomass


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Hi all,

A quick update from the Golden TGV Bullet Train that arrived at Week 8 gate on March 14. The service in first class has been tremendous so far. Feeling very good no side effects. 9 days left and I'm done. I'm interested 3 months post EOT but something inside tells me not this time. Its gone. More to come soon.

PRIOR TREATMENT:

ALT: 65
AST: 54
Eosinophil 7.5 a little high (range:0.0-6.8)
Platelets 86 (Low)
HCV RNA: 336,000

WEEK 1

ALT: 55
AST: 50
Eosinophil 0.18 (normal range)
Platelets 100 (Low)
HCV RNA: Here's the kicker, study specifics blocker are inlace for subjects results BUT will know more next week.

WEEK 2

ALT: 49
AST: 38
Platelets 102
HCV RNA: Unknown

WEEK 4

ALT: 37
AST: 28
Platelets: 104
HCV RNA: UNKNOWN - specifics blockers are in place for subjects results. Week 8 visit on March 14.

WEEK 8

ALT: 39
AST: 30
Platelets: 107
HCV RNA: Undetected



__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
Canuck


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Me too! Mee too!

As is tkflex36, I am sure!  smile Canuck



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
JimmyK


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I am also interested.

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
robertsamx


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Hi Web--  just stopping by to see how things are going?  Hope all is well.   Any news on your blood work?   RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
wmlj1960


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Hi Michael, and welcome from me also. No side effects so far sounds encouraging and we hope it stays that way. Looks like you've got your strategy for staying healthy through this all planned out and that should help a lot. Hopefully the sleep will come once you get settled in to this routine. We'll be watching for your updates and certainly wish you well throughout treatment all the way to SVR. Glad to have you on board!   smile



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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Tig


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It is a great protocol and trial. Hoping you get into the active meds first off. You mentioned no side effects and that's good to hear too. We'll be keeping a close eye on ya Michael! Stay in touch smile



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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robertsamx


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Web,  Yep you pulled a great Trial. Your going to kick its butt.  Happy for you!!   RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
webtomass


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Hi RC,

 

Thanks for the welcoming. Believe its referred as Polaris 3.

https://clinicaltrials.gov/ct2/show/NCT02607735

There's 3 arms I'm in the Deferred Treatment Subsidy group. This study just started and believe I might be one of the first to start the treatment. Its ongoing. So no early results. Will keep everyone informed. Did week 1 blood tests this last Tuesday. 

 



-- Edited by webtomass on Saturday 30th of January 2016 05:18:50 AM

__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
robertsamx


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Welcome Webtomass.  Glad you found us. Are you on the Polaris study?   The combo you are on should do the trick!  I can't wait to see the results of this trial, It's too bad we may not know the results for a year or better. Ask your study nurse how the others in the study are doing, are they clearing the virus early?  Best of luck to you.  RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
webtomass


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Hi Tig,

Thanks for the feedback. Yes I cleared a long list of nutrients and amino acids for this trial. I stopped many of them before I started. i.e. NAC, Milk Thistle, Trans-Resveratrol, and other liver herbal concoctions. My main source for nutrients during this trial are not uncommon for the main part. i.e. BCAA, B complex + B12 injection once a week, Vitamin D,E,A  etc... But most of all PH balance +8 water lots of it and green juices and shakes. Lots of organic food. So far this is been a breeze frankly. I do take a sleeping pill  every other day as this is my main liver symptoms... Can't fall asleep easily. 



-- Edited by webtomass on Saturday 30th of January 2016 03:01:51 AM

__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
Tig


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Hi Michael,

Welcome to the group! Congratulations for getting on the trial, it's looking very promising. We've got another member that is on that trial too and doing well.

I have to ask, what kind of supplements are you taking and have you cleared them with the trial head? They often are deadset against the use of them during treatment and very particular during a trial. A good nutrient rich diet is great, make sure you're getting plenty of fluids too.

We've got some others here on or finished with V Pak, one relapse. They'll introduce themselves soon. Lots of good people here! Good luck...



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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webtomass


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Hi Everyone,

New treatment: Sofosbuvir, Velpatasvir, GS-9857. 1 pill a day with food. I'm in the Deferred Treatment Substudy. This will be the one for all genotypes that will hit the market later this year or early next year.

Its been 10 days and no side effects whatsoever. Vieira Pak + Ribavirin treatment relapsed @ 12 weeks EOT this past fall. I run, Inline Skate (over 50 K in last week) and consume lots of very good nutrients, supplements, and food. Hopefully this one does its magic. I'm doing all I can on my own but need this. Anybody else failed to cure on Viekira Pak? Feedback or insight from anyone would be gratefully appreciated.

-----------------------------------------

Contracted 1980's - blood transfusion
Relapse on first treatment - Viekira Pak + Ribavirin
Fibr. Stage F4 Severe Fibrosis
Fibroscan score 28 kpa
Genotype 4 - VL 233,000 at beginning of treatment
Current Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment



-- Edited by webtomass on Saturday 30th of January 2016 01:30:40 AM



-- Edited by webtomass on Saturday 30th of January 2016 01:34:58 AM


[edited dotted line to fit forum display]
-- Edited by wmlj1960 on Friday 1st of April 2016 05:33:05 AM



__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
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