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Hep C Discussion Forum -> On Treatment -> All Aboard the ZEPATIER Train 12 or 16 weeks w/wo RBV
Post Info TOPIC: All Aboard the ZEPATIER Train 12 or 16 weeks w/wo RBV
MyMallards


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RE: All Aboard the ZEPATIER Train 12 or 16 weeks w/wo RBV
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I MOCK thee, Dragon! Mock. Mock. I withhold CPR and personally sign your DNR document. Tossing your remains to the passing Harvoni train where you will be mercilessly stewed (on bisquits) or elimated like toxic waste. Whatever the wizards decide. 



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58 yo with GT1b for 32 years post blood transfusion after first childbirth, F3/9.6 kPa, VL 890K,Treatment naive, Liver enzymes ALT 33, AST 39, Cryoglobulinemia and pos Rheumatoid factor, Started 12 week Zepatier on 5/2/17. 4 week: VL Undetected!  ALT 15, AST 25. 

 

 
JimmyK


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Tig56 wrote:

I sense some drama going on! Hmmmph! I'll have you know, a properly stewed Dragon casserole is quite lovely. With bisquits, don't forget them! wink

  I forgot the biscuits.



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Tig


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I sense some drama going on! Hmmmph! I'll have you know, a properly stewed Dragon casserole is quite lovely. With bisquits, don't forget them! wink



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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JimmyK


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MyMallards wrote:

Where are we supposed to put the pieces of dying dragon? Is it considered litter (or compost) if we toss it out a window? 


 Do not listen to Tig on this one. (Man am I gonna get it!)

This is nothing but Toxic Waste. This Dragon dead or alive serves no useful purpose. Setting aside the crap, I would not so much as see it fit to share the same bowl with the foulest of Turds in light of the many innocent Gold Fish that are flushed daily. 

Also let me be the first to say it is not a dying Dragon, it is dead! Congrats on the 4 week UND! Let the Zep continue now with the mop up. You got this!

I am very sorry that you are not feeling good but the fact is you get to look up from the pain and mock The Dragon that thought itself something. YOU got it!

Continue the course and join us that are SVR12+ in due order.

JimmyK

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Tig


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For those needing drug information, this is a good pdf 

Zepatier Monograph

 



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Tig


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You have to collect all pieces of dead and dying Dragon. We have a side business using that carcass! See below  

 



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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MyMallards


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Dragging aboard with use of the handrail. My body is slower than my mind due to extrahepatic arthritis and cryoglobulinemia. So, I know where I am but it's a challenge to get there. Ha!  I've just started my 6th week of Zepatier and I plan to gracefully leap to the platform by the time I reach my station. Already VL Undetected at 4 weeks so there's hope!

Zep Heads always pack a duffle full of hope!

Where are we supposed to put the pieces of dying dragon? Is it considered litter (or compost) if we toss it out a window? 

Happy trails to all, 

Christine



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58 yo with GT1b for 32 years post blood transfusion after first childbirth, F3/9.6 kPa, VL 890K,Treatment naive, Liver enzymes ALT 33, AST 39, Cryoglobulinemia and pos Rheumatoid factor, Started 12 week Zepatier on 5/2/17. 4 week: VL Undetected!  ALT 15, AST 25. 

 

 
Tig


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I'm bumping this thread back into discussion. We didn't have many people on this protocol at the same time, so I think it's time to reintroduce it. I trust all you Zep Heads (how's that for a nickname!) will take it and run! Feel free to make it yours, because it is. All Aboard!!

image.gif



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Tig


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Some continuing good news regarding Zepatier.   

"Zepatier treatment for 12 weeks, with or without ribavirin, was highly effective for induction of sustained virologic response in patients infected with hepatitis C genotypes 1, 4 or 6, who failed prior peg-interferon and ribavirin treatments, according to the results of the C-EDGE Treatment Experienced trial. 

SVR12 was also achieved by patients with cirrhosis or a null response to previous treatment in this trial, and the treatment was generally well tolerated."

 



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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JimmyK


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LOL yep being a Grandfather has its' Perks that is for sure.

My screening today did not go well. Back to the ticket station I guess.

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Tig


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OH COME ON Jimmy!! People simply don't want to miss the opportunity to send their children to Uncle Tig's house! I love the little ones and spoil the big ones. I've got a Amazon Prime account with a direct link to the drum section, how'd you know? LOL! biggrin



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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JimmyK


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Tig56 wrote:
 I wish I could've had grandkids first! They're fun and you can send them home full of sugar and promises. It's just great.

 

Sugar and promises? No way brother. Sugar is not good for them and promises are not needed. Just be Grandpa and that is good enough.

If you want to send them home and REALLY be happy, send them with noisy toys. A lil get back is not such a bad thing and can be therapeutic. 

;)

 

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Tig


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Hi Echo,

Greeting from one of the old timers around here!! As you've already realized, we are a big family of friends and fellow warriors. Nobody here takes anything for granted, will remain non judgemental, and assure you that we're here for you throughout this journey. We don't offer medical advice, but we're pretty good at offering helpful educated opinions. One thing I can assure you of is, we aren't judgemental and welcome everything you care to share. Some of us have traveled many miles and many decades with this disease and it doesn't matter how or where we got it, but that we get rid of it.

Zepatier is yet another new weapon in the arsenal against this disease. As you're already aware, the old treatments with Interferon were hell and I'm glad you were able to avoid them. The new DAA's, which Zepatier is considered, are extremely effective and as they continue to do research and trials, they will continue to improve. You have chosen to treat at a very good time. Your odds of success are excellent and the incidence of negative side effects has gotten quite low and those that come along, are easily tolerated. So do yourself a big favor and take a deep breath....... no worries okay? You're going to do fine and we'll be along on this ride with you. If you have any questions, just ask and we'll do our best to find the answer or solution. We try to always be available and as you can see, there are a lot of folks here around the clock that already consider you a friend.

There will be some differences in how you feel during treatment, but I don't believe you're going to have any problems taking care of those two wonderful kids. We're a big family here and if there happen to be times that the stress starts to mount, check in here and we'll help. Most of us have children, some young, some older, I'm a new Grandpa and let me tell you, I wish I could've had grandkids first! They're fun and you can send them home full of sugar and promises. It's just great. Seriously, you'll do just fine and the kids will have their Mom back, happy and healthy in no time at all.

I don't know how much information you have on Zepatier, but I thought I'd add a couple of links to the current data. The thing to concentrate on is it's rate of success, it's high! So do your best to relax, not worry unnecessarily and plan for success. Good luck!

Zepatier 01

Zepatier 02



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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JimmyK


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I was just reading your introduction Silverecho and would like to join in welcoming you to the Family!

Here we laugh together and we cry together. We understand how the other feels and share in that. We also recognize the importance of keeping a positive attitude and in that we attempt to build each other up.

In particular, the recent new DAA's have given us here many sound reasons to lift our heads. It is amazing to see the progress and watching each other undergo the battle is inspiring.

I recently failed in my first attempt. My Doctor is in the middle of considering the best path forward.  This morning I will going for a screening process for a new triple combination trial but I may not be accepted.

The fact is proton inhibitors would exclude me and I have a problem with Zollinger Ellison Syndrome. OTC Omeprozol does the trick but I am not supposed to take it on trial. They told me to use Zantac instead and after four days I know that was not going to work. This morning I will ask if they can prescribe something stronger that would qualify me and if not it is back to the drawing board.

I noticed you mentioned how scared you are of failure or whatever. Don't be. Not only does it do no good it is baseless at this point in time. New treatments are flooding the market and it feels like they are on the verge of a very simple cure. In the mean time no worries, get comfortable here, read and again, welcome to the Family!

 

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
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Congrats JimmyK and Silverecho on approval of your meds.   Hoping and praying your rides are smooth and your journey ends in SVR land.  Be well.    smile 



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
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Hello! I hope you are doing well! I was just prescribed Zepatier this week. I am in Canada. I'm so nervous! I am late 30's, I have been infected for 20 years already. I have 1a, and a super low viral load (300,000 approx). I have never been on treatment. Did you start taking it yet? I'm really scared about side effects as I have two children that depend solely on me. Hoping to get some info from someone taking it already. Best wishes on your journey!



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38 yr old DX 1999, genotype 1a

VL 300,000, F1

Starting Zepatier Mar 23, 2016

4 weeks into treatment - Undetectable April 19, 2016 - ALT 9
JimmyK


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I am touched.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

And I want to know who did that! noIdiot



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Linuxter


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... order has been canceled per your request, luxury car sent over to the Harvoni train , you get the boxcar and a crate with a woopie-cushion (w/ Surround Sound and 60" plasma) ... and ... bonus ... there's plenty of room in there for the scooter.

Note: A ramp has been added to allow for scooter excursions.

 

D  (The logistics were almost too much for my feeble brain to fathom ... but we got 'er done).



-- Edited by Linuxter on Tuesday 16th of February 2016 08:50:03 PM



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
JimmyK


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Linuxter wrote:

Hey Jimmy,

The nice thing about train cars is that they can be uncoupled then coupled to another train ...

... not to worry, you'll still have the nice decor (with Corinthian leather seats per your wife's order) as well as the weight training car ... we put in a rush order to get them switched over ASAP!

 

no I have not changed enough yet. My first thought was...... https://www.youtube.com/watch?v=V3FnpaWQJO0

 

No need for weight training. May consider during recovery mode but do not intend to be on a train then. That calls for the scooter. There is positively no better way to get your head clear ( for me anyways) than to just get out and ride. 

You can also save the leather seats for the Harvoni train in that that is the one the lil Lady will be on. She kind of likes that stuff. As for me, so long as the one I am sitting in has not been peed in I am cool. In that this is such a new train should be good in that aspect.

Oh and music. I will gladly trade all the fluff for a good sound system. This ride calls for something mellow. Dear Lord where we have all been and now here before us is a cure? Indeed something mellow.... https://www.youtube.com/watch?v=9Pes54J8PVw

And then.. https://www.youtube.com/watch?v=TJAfLE39ZZ8   just for the cruise.

 

And then when it is over go out and party just a little.... https://www.youtube.com/watch?v=Apm0QVGeQ7g  YUP!

 

JimmyK

 



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Linuxter


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Hey Jimmy,

The nice thing about train cars is that they can be uncoupled then coupled to another train ...

... not to worry, you'll still have the nice decor (with Corinthian leather seats per your wife's order) as well as the weight training car ... we put in a rush order to get them switched over ASAP!



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
JimmyK


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Tig56 wrote:

Hey Jimmy,

You're in buddy! Congratulations on getting this train rolling. I'll be waiting at the station to bid you well. Let us know what you hear. We'll be on the platform with our pom poms flying!!!

       

 



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Tig


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Hey Jimmy,

You're in buddy! Congratulations on getting this train rolling. I'll be waiting at the station to bid you well. Let us know what you hear. We'll be on the platform with our pom poms flying!!!



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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JimmyK


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Thanks Scruff.

Still holding for final ok but name went on list and Dr. is pursuing it in a strong way. They are contacting Gilead now so just waiting for one more call. 



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Scruffy


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RE: All Abord the ZEPATIER Train 12 or 16 weeks w/wo RBV
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"I deserve every rotten side effect that comes my way and then some so no problem"

When I was on the old triple treatment the nurse at the infusion center said "Why are you on this treatment it has the worse side effects" I answered " cause I deserved it" She shook her head. hahaha We must be related some how.

Anyway good luck on the new train.



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Geno 1a null responder 2004 inter/riba   finished incivek,peg/riba 48 weeks May 17th 2014. undetect weeks 4-12-32.  EOT+7 undetect. EOT+24 SVR!!!!! EOT+!YEAR SVR!!!!
JimmyK


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Sorry had to change trains.

Gilead Sofosbuvir/Velpatasvir/GS-9857 Clinical Trial.

You just got here and we did all this nice decor just for you!

My apologies. The conductor came by, checked my ticket and told me to get off I was on the wrong train!

no Idiot!



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
bubble


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Congrats to Jimmy the "Merck Man" !    Good Luck to you.

 

Booooaaaarrrrrrrrrrrrdddd !



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60 yrs. Geno1b 2001. 9mil. VL. �Failed Post Riba/Peg tx. 2006 46 weeks. Diagnosed 1A 2015(?) F3 fibr. 225k VL. Vikera/Riba 12 weeks 3/20/2015. "Undetected" start to finish. Undetected 1yr post tx.
wendyo


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First to board...Mr. Jimmy!rovos-rail-cabin-590.jpg



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 
Mike


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Congratulations JimmyK!! I am very happy for you. I will keep you in my prayers as you move through this treatment period.

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1-18-16 referred to gastroenterologist;  AST 191 ALT 246, Viral Load 1,976,000, Alpha Feto Protein/Negative for Cirrhosis. Genotype 1 a. Tx began 3/9/16 Harvoni, 8-12 weeks

 
Canuck


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Hey JimmyK,

What a difference a day makes, eh?

Now you get to wear a grazo/elba/riba shirt?!

It doesn't sound like a "trial" (if your Dr. has already "ordered" the drugs), is it?? If so, what's the trail number?

If it IS a trial, has it already been decided in advance somehow that you WILL get 12 weeks of Zepatier AND RBV and not 16 wks. of Zepa without RBV??

I understand you are feeling lonely?hee hee

Happy you got your treatment options so soon!smile

Best, Canuck  

  



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
Linuxter


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First Class all the way Jimmy ... enjoy the ride!

Oh, and you will be assigned a personal food taster (for your safety).

I hear they've attached a weight training car right behind this one.

The only way to ... well, you get the idea.

royalscotsmancabin.jpg



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
JimmyK


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I just love it here.

 

Y'all are great!

 

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Tig


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Okay, I had to go shopping. But we'll take care of you along the way!

 



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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JimmyK


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Tig I do recognize I can have most any seat, including up front.

What kind of bugs me is generally sitting up front you have some rather nice folks asking if they can get you anything. In this case I was checking the "Official Web Site" and based on all the under construction sort of screens I get, I don't thing the crew is even on board yet.

https://www.zepatier.com/

 

Can someone...ANYONE get me one of those neat little bowl of nuts or something??? Also a pillow and a blanket maybe?? HELLO?

 

LOL <perks>

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Tig


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Gracie's right Jimmy! This train is brand new, so you can have that new car smell if you want! You can also sit in First Class and have your pick of any leather seat available. You might invite your wife, she'd enjoy the leather too! It's your train, you can invite anyone you want, lol! 

Don't sweat the bike at this point. You might find out that the ride is smoother than you think and an occasional cruise might do your Riba brain some good! One day at a time, you'll get through it and life will be good smile



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Gracie


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Your the first to board so you can get an awesome seat. Sit back and enjoy the scenery.



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  1. Gracie

1A. Previously treated non responder Rebetron in 2000 And Incevik in 2014 with a breakthrough at week 12. Fibroscan 15.5. VL 6,000,000. Finished 24 weeks harvoni on Dec. 19, 2015. SVR. Latest Fibroscan 8.8.
JimmyK


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Greetings Scott.

Well this is the communication I got, verbatim from my Doctor this morning.

Good Morning Mr. Phelps

"I think your choices come down to Harvoni for 24 weeks (with ribavirin), or zepatier with RBV for 16 weeks. After looking at the resistance profile and your omeprazole dose, I think Zepatier is preferable. I have prescribed it and will order from your pharmacy. Please let us know when you get it - DO NOT START WITHOUT NOTIFYING US.
Thanks,
Norman Leslie Sussman, MD"

(He did not really say Mr. Phelps but it kind of had the same ring to it. LOL)

https://www.youtube.com/watch?v=mWGeRgFa-hI

 

Nothing but a new train ride is all.

I can't speak to why not 2 but likely a stock market issue. These greedy folks do thing$ for one rea$on.

Side affects for me based on my last and recent round of RiboMonster are expected to be less than fun let's say. However I am not in this for the fun so it will be what it will be. I deserve every rotten side effect that comes my way and then some so no problem. Just time to deal with it is all.

My Bike will no doubt remain parked for awhile and so will I. Nothing a lil battery tender and a fuel line preservation can't deal with. ;)

JimmyK

 



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Scott18927


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So wow, that was just approved?  How come only 1 and 4?  I know that 1 is most common and hardest to get rid of but why 4?  Why not 2? 

 

 

Good luck, is this one supposed to have any side effects? 



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40 y/o M, GT 2A, Dx 2000.  Attempted 2 Tx with interferon and rib. Fibroscan F3; Tx 3 - SOT 1/26/16 Rib/Sov.  EOT 4/18/16.  AST/ALT 16/11.  VL = UND.  EOT + 4 tests will be 4/16/16
JimmyK


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I am ready. I want my life back and have no fear.

It does feel a bit odd to be the first one here on this ride but hey, I have my pick of seats and it kind of has that new car smell.

Wait that was Carols new car, this is a train.

Tickets! Tickets Please!

 

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
Tig


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It's coming, you just have to jump on when you're ready!!

 



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JimmyK


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All Aboard the ZEPATIER Train 12 or 16 weeks w/wo RBV
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All aboard!

 

Hello?     Heeeeellllloooooo?

 

no Oh boy this is going to be a long boring nobody to talk to or anything kind of ride.

Hello?  Booooooooooaaarrrd!

 

<sigh> Ok I am wearing my Pioneer hat here. Let's do this. Onward upward and tallyHo gonna kill me a lizzard!

 

JimmyK

 



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
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