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Post Info TOPIC: HCV 2016 Research and Updates


Guru

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RE: HCV 2016 Research and Updates
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Rumor has it that the "Masochist Society For a More Painful Life Experience" folks are trying to get it approved as a recreational drug in Colorado.

 

I have not confirmed that so don't quote me.

 

no



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."

Tig


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Hey Matt,

I think all of us that have taken Riba felt like it was just plain lethal in general! A needed evil sometimes in the quest to annihilate this disease...



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Guru

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Hey Tig

This article describes the action of RIBA again'st' HCV as "lethal mutagenesis"

RIBA still remains a somewhat a enigma, but it has helped many of us relapsers handle mutations during treatment.

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 



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Good article Tig.

I think the 'Extrahepatic consequences' has been glossed over. From my research, the mixed cryoglobulinemia often does not resolve after SVR. Vasculitis affecting the nerve sheaths often results in permanent damage, which is why peripheral neuropathy can be a permanent symptom after SVR. The muscle/tendon/joint issues may also be permanent. HepC is related to Insulin Resistance, which may not resolve after SVR.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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I am going to have to reread a few times. Lot's of incredible information!

Thanks

 

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



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Thanks Tig.   Very good read. lots of new info.  Gives me hope!!   RC



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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   

Tig


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I thought this was a good article and recommend it for those in search of current treatment data. There is mention of two protease inhibitors, Telaprevir and Boceprevir (NS3), they should be disregarded. They are no longer being prescribed, thank goodness... I was one of the last to ride that train, thankfully. Anyway, this is informative and provides both history and current data on the new treatments.

http://hepatitiscnewdrugs.blogspot.com/2016/03/recent-advances-in-managing-chronic-hcv.html



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 

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