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Hep C Discussion Forum -> Post Treatment -> After SVR can liver disease worsen?
Post Info TOPIC: After SVR can liver disease worsen?
Pablito


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RE: After SVR can liver disease worsen?
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Ah, yes, stigma Tig...don't even get me onto that topic!  If HCV was a form of childhood cancer rather than a condition associated with stigmatised groups then we wouldn't have this ridiculous situation where the new DAAs are priced so ridiculously high to preclude treatment at a population level.  

I don't know about elsewhere but here in the UK the Hep C Trust did sterling - no pun intended - work in challenging stigma, and played a large role in the recent National Institute of Clinical Excellence (the body who decide what the National Health Service can spend its money on) guidelines...as of the 1st of March 2016, in principle anyway, anyone with HCV in the UK, regardless of fibrosis staging, who asks for treatment with the new DAAs cannot be refused...it will be interesting to see how this one plays out and whether it will bankrupt the health service here.



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44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.
Tig


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It will Pablo, it will.... Great stuff with very impressive rates of SVR. In 96 when I was diagnosed, the rates of SVR were less than 20%, if you were lucky. I was not. We've come a very long way towards improving both the attitudes, stigma and treatments. You have every reason to be stoked for success!



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Pablito


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Good, well-written article Tig.  Some medical articles wherein endless lists of problems/symptoms/pathologies are presented without a balanced view around their likelihood give me the fear and are more about scientists getting published rather than being truly informative...

...on that note, when I was diagnosed with HCV in 1996 I was given a book to read called "the hepatitis C handbook" or something similar, written by a HCV sufferer.  He did just as described above and filled me full of hopelessness, especially at a time when there were no effective treatments available.  The author even stated that he had chosen not to have a family for ethical reasons...really, talk about limiting your life!  It had a profound negative affect on my mental state at the time and it took me some 10 years or so to think more positively after I had by then realised that I hadn't developed any of the endless, obscure problems.  Subsequently, I'm very selective about what I read, but the article posted is good.

Sorry, bit long-winded, but in reference to the OP's question my view is the same as Tig's article: yes, liver disease can worsen after SVR but only for a small percentage of people and mostly, unfortunately, for people with advanced fibrosis; which I am on the verge of so I really hope the sof/vel/GS-9857 trial I am on works.

Pablo



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44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.
laughinggull


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I have Duputrens contractures and have had it for 10 yrs. I am Gt 1a and have not done treatment yet. I have read that Hepatitis C makes you more at risk of getting Duputrens. I am a female and it is rare for women to get this disorder.

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Shadowfax


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Now I have two articles to read, first about Dupuytrens Contractureand get the liver one!

Thank you for sharing.

 

SF



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65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *
Tig


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This is an informative article that does a good job of explaining the reversal, maintenance or progression of the liver after SVR. Long read but interesting. 

Liver Disease after SVR



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Linuxter


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I have been Dx's with the early stages of Dupuytrens Contracture but as far as I know it doesn't have anything to do with HCV.

I was Dx'd with it years ago before being Dx'd with HCV. Here's some good information about it from a reliable source (Mayo Clinic).

I'd be cautious about reading to much into it ... it effects a lot of people as they age and tends to progress rather slowly, I saw a specialist and he would not operate on it saying it wasn't anywhere bad enough to bother and suggested massaging the area and stretching my little finger back carefully to keep things flexible.

Congrats on finishing your Tx, I will assume you reached SVR? 

 

Dave

 



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
Transient


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Hi friends, sorry for the gloomy question, however, I've not been feeling great of late (chronic fatigue, etc.). I've also developed a suspicious bump on my right hand, which I have had checked out by my GP and ultrasound and it has been Dx as early Dupuytrens contracture - and so I'm wondering about this subject.

If you are reading this Mallani/Mike could you please share with me when, during your hep c trajectory, did you develop Dupuytrens, was it before or after Tx. I am approx 1 year post Tx. And anyone else who has developed Dupuytrens, your input would be appreciated.

Cheers :) 

PS I'm not of Scandinavian descent - apparently Dupuytrens is aka Vikings syndrome or something, because its a genetic hiccup peculiar to them.

 



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Ex-HCV G3a. Pre Tx teas results, Fibroscan 7.6; APRI F3; Ultrasounds have my liver as either cirrhotic or normal. Post Tx tests Fibroscan 3/16 4.8kpa; bloods all normal range; Ultrasound, cirrhotic. Confused!
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