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Post Info TOPIC: SVR12!!! :)
Tig


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RE: SVR12!!! :)
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That's worth investigating Zlick. I think it will require some routine RAV testing to see which variants may exist. With the combo's available and those in the pipeline, I think we'll witness a fairly bullet proof set of protocols in the near future that will hopefully start covering all the bases. We can hope, but considering the advances made since we first treated, the outlook is very promising.



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Tig

64 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 7+ years!

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So happy for you Zlickster. I think at 12 weeks out its done and dusted for you. 

I was on same treatment as you but have G2. I think because my liver is in such a bad state that they wanted to make sure it's gone. My SVR 12 isn't until mid August as I ended up doing a further 12 weeks of Sof/Dak. 

Like you though, I am wondering what the options are though if it's still there. I don't think Vel has been approved in Oz though- we are miles behind you in everything, so at the moment I'm just hoping that relapse is not a word I need to fear. 

Once again, so glad it's turned out so well this far for you.  Maybe it feels like a bit of an anticlimax after all you have been through?? Don't forget, no matter how you feel physically, facts are you have beaten a killer disease.

Yaaayyyyyy!!!!!

Syd



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Contracted Hep C 1969. Genome Type 2, treatment naive. Began 12 week RIBA/sof/Dac on 12/11/15. Cirrhosis. VL before treatment 4m. Treatment extended another 12 weeks without Riba. No virus detected at 9 weeks.



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Cheers folks, as i mentioned, not in a full celebration mode yet until SVR24 :)

as for post tx life, i presume it's more psychological, since i was more optimistic and felt better after i have finished Peg+Riba than this round. Might be, since i was pretty exhausted from Peg, that back then as blood cells were recovering and i regained my weight back, that was THE impression of getting better. This time after easy no sx tx like this, heck i feel the same. Maybe if i have been on double dose of Riba, then i would have feel something from RBBC recovery :)

@Tig, cheers man! Always good to hear Another one bites the dust for another SVR (tho it's bit ironic since Freddie lost battle with HIV)

@Syd. Sof+Dac-+Riba was best option for us GT3s, until Vel was introduced as Dac killer. I wonder can we be retreated, in case of relapse, with Vel?

best



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!




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YaY! yaY! biggrin  Huge Congratulations 

12 weeks SVR! Whooo hoooo 

 

Alison

 



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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Hey Zlick!

Really big congrats on your EOT+12.  Such long hard work you have done, and you did it SO well!

Another "3" DONE! A "former" 3, "used to be" a 3, "was" a 3 - oh ... don't I just LOVE using the past tense!

Please do keep us posted, on EVERYTHING!, from EOT+24, to if your tinnitus ever improves at all over time.

I know why you insist on restraining yourself from party hardy, but, you will not stop US from doing so for you, as WE all believe you did it, even if you won't allow yourself to believe it quite yet. I know, once burned, twice shy, but your numbers (with these drugs) tell a dif story this time.

You go ahead and party soft if you have to, and WE'LL do all the party hardy!

Really happy for you.

Thanks for letting us know about the rumour you heard - rumbles of generic vel in China. Sounds like it won't be long now, before many more 3's and other GT's will have access to these fantastic new daa's. Will also be interesting to see if vox will start to come along with sof/vel too in the very near future. 

I hope, one day soon, riba will not be required.

Good job you did man. biggrin C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Fantastic Zlick,

Fellow sof/dac/RIBA traveller. How great to know it worked so well for you. My own post week 12  isn't until August and your news has given me a lift.

so happy for you.

Syd



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Contracted Hep C 1969. Genome Type 2, treatment naive. Began 12 week RIBA/sof/Dac on 12/11/15. Cirrhosis. VL before treatment 4m. Treatment extended another 12 weeks without Riba. No virus detected at 9 weeks.



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Hey Zlikster... HUGE congratulations to you on SVR12, your perseverance has paid off at last!!!! 

My goodness, you`ve waited such a long time for this and I`m so pleased to see this news!!  w00t.gifw00t.gif

Onwards to SVR24 indeed... we`ll be looking forward to celebrating it with you!

 

 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Congratulations dearbiggrin

We've been here a long time waiting for this, right? Your turn now!..fingers crossed it will work, try not to worry.

Many blessings, Iris 



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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Very happy for you Zlick!  Let us know how you feel moving forward.biggrin



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Hi Zlick

       Man you have been through the ringer. You really deserve SVR-12. Looks like the second R/X was the charm.Really happy for you yawn      RC

 



-- Edited by robertsamx on Tuesday 28th of June 2016 10:09:51 PM

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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   

Tig


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Hey Zlick,

HOORAY!!!!  So glad to hear you finally found the success you have fought long and hard for. You can wait for SVR24, which will simply double nail the coffin of your now deceased Dragon. I know that each test, regardless of when, gives you a touch of anxiety, but rest assured you're done my friend. We've all been waiting to hear your good news, but I know Malcolm has been waiting to hear from you. He'll be very pleased to know you've achieved SVR12. 

I wish you the very best and hope you check in on a regular basis. We'll be looking forward to your SVR24 confirmation and celebration. Personally, I'm putting on my dragon stompers and going to start dancing to Queen's "Another One Bites the Dust" in honor of your SVR12!!



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Tig

64 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 7+ years!

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Excellent news! Congrats on SVR12

SF



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65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *



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cheers folks!

@Pablo, 12w of Sof+Dac (chinese APIs, encapsulated in Sydney bought via Dr.Freeman's FixHepC buyers club), and 600mg of Riba daily. Barely detected (16 IU/ml) on w4, UND from w8. Looking fwd to SVR24, then i can close the hcv chapter in my life i hope :)


I have already seen (unverified tho) Velpatasvir APIs on chinese market. Sof+Vel seems to be even better combo than Dac+Sof.


best



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!




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Congrats Zilkster.  

Out of curiosity how many weeks of sof/dak/rib did you do?

Pablo



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44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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Love it! Congrats Zlik.



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Awesome news!! So happy for you ... you did it !   Enjoy ! CC



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F 63,  1b  1974, no cirrhosis, fibro scan 5.8 F0-F1,fibro test .37 ,V/L 702987, ALT 90, AST 75.  ABBVIE Topaz II on 10-30-14 Viekira Pak no RIBA , EOT 1-22-15 SVR, ALT 37, AST 29, 4-15-15 SVR12 - fibro test .22,  1-21-16 SVR 52 ,  1-21-17 SVR 104! 1-21-18 SVR 3 years ,2020 5 years



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Hey Zlik,

I think is safe to say a HUGE Congrats to you my friend, you are Cured and HCV-FREE!

WTG! It's been a very long road but you did it!!

You Dragon Slayer! smile

 

Congrats,

Dave



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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just got my PCR EOT+12w result today, undetected! Now, i will again lay low and won't celebrate yet, since my hepa told me to do EOT+24w PCR too.

A big thank you to all the folks on this forum for all the help and support! And of course a BIG thank you to chemist Jeremy L Clark for inventing a wonderful molecule C22H29FN3O9P (Sofosbuvir), hope he gets reckognition one day for what he has done. A big thanks to whoever discovered Daclatasvir @ BMS (hope inventor wasn't ripped off like Mr.Clark was). Huge thanks to amazing Dr.Freeman and his mission to bring affordable generics to everyone.


Onwards to SVR24 :)




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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!


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